Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ETNK1

Gene summary for ETNK1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ETNK1

Gene ID

55500

Gene nameethanolamine kinase 1
Gene AliasEKI
Cytomap12p12.1
Gene Typeprotein-coding
GO ID

GO:0006629

UniProtAcc

Q9HBU6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55500ETNK1P37T-EHumanEsophagusESCC2.37e-204.37e-010.1371
55500ETNK1P38T-EHumanEsophagusESCC7.82e-041.34e-010.127
55500ETNK1P39T-EHumanEsophagusESCC2.64e-254.45e-010.0894
55500ETNK1P40T-EHumanEsophagusESCC4.97e-175.04e-010.109
55500ETNK1P42T-EHumanEsophagusESCC6.28e-256.16e-010.1175
55500ETNK1P44T-EHumanEsophagusESCC1.33e-112.34e-010.1096
55500ETNK1P47T-EHumanEsophagusESCC4.58e-501.02e+000.1067
55500ETNK1P48T-EHumanEsophagusESCC7.27e-143.03e-010.0959
55500ETNK1P49T-EHumanEsophagusESCC7.15e-101.28e+000.1768
55500ETNK1P52T-EHumanEsophagusESCC9.19e-174.99e-010.1555
55500ETNK1P54T-EHumanEsophagusESCC1.43e-359.08e-010.0975
55500ETNK1P56T-EHumanEsophagusESCC9.28e-041.02e+000.1613
55500ETNK1P57T-EHumanEsophagusESCC1.53e-295.22e-010.0926
55500ETNK1P61T-EHumanEsophagusESCC1.16e-165.12e-010.099
55500ETNK1P62T-EHumanEsophagusESCC5.10e-519.33e-010.1302
55500ETNK1P65T-EHumanEsophagusESCC8.35e-152.54e-010.0978
55500ETNK1P74T-EHumanEsophagusESCC1.62e-226.09e-010.1479
55500ETNK1P75T-EHumanEsophagusESCC2.03e-204.26e-010.1125
55500ETNK1P76T-EHumanEsophagusESCC1.18e-346.39e-010.1207
55500ETNK1P79T-EHumanEsophagusESCC1.64e-407.72e-010.1154
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006650ColorectumADglycerophospholipid metabolic process83/3918306/187235.40e-033.55e-0283
GO:0006644ColorectumADphospholipid metabolic process101/3918383/187235.80e-033.67e-02101
GO:0045017ColorectumADglycerolipid biosynthetic process69/3918252/187238.33e-034.88e-0269
GO:0046486ColorectumSERglycerolipid metabolic process82/2897392/187232.26e-032.17e-0282
GO:00066441ColorectumSERphospholipid metabolic process79/2897383/187233.94e-033.24e-0279
GO:00450171ColorectumSERglycerolipid biosynthetic process55/2897252/187234.47e-033.56e-0255
GO:00066501ColorectumSERglycerophospholipid metabolic process64/2897306/187236.41e-034.60e-0264
GO:0008654ColorectumFAPphospholipid biosynthetic process54/2622253/187238.88e-049.08e-0354
GO:00066502ColorectumFAPglycerophospholipid metabolic process62/2622306/187231.54e-031.38e-0262
GO:00066442ColorectumFAPphospholipid metabolic process74/2622383/187232.24e-031.83e-0274
GO:0046474ColorectumFAPglycerophospholipid biosynthetic process44/2622211/187233.98e-032.76e-0244
GO:00450172ColorectumFAPglycerolipid biosynthetic process50/2622252/187236.32e-033.95e-0250
GO:00086541ColorectumCRCphospholipid biosynthetic process49/2078253/187237.07e-051.51e-0349
GO:00066503ColorectumCRCglycerophospholipid metabolic process55/2078306/187232.10e-043.55e-0355
GO:00450173ColorectumCRCglycerolipid biosynthetic process47/2078252/187232.47e-044.06e-0347
GO:00066443ColorectumCRCphospholipid metabolic process65/2078383/187233.21e-044.95e-0365
GO:00464741ColorectumCRCglycerophospholipid biosynthetic process40/2078211/187234.91e-047.02e-0340
GO:00464861ColorectumCRCglycerolipid metabolic process64/2078392/187231.01e-031.19e-0264
GO:00086544EsophagusESCCphospholipid biosynthetic process162/8552253/187232.59e-095.73e-08162
GO:00464744EsophagusESCCglycerophospholipid biosynthetic process135/8552211/187235.75e-081.02e-06135
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ETNK1SNVMissense_Mutationnovelc.765N>Tp.Lys255Asnp.K255NQ9HBU6protein_codingdeleterious(0.01)probably_damaging(0.985)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ETNK1SNVMissense_Mutationnovelc.649G>Ap.Asp217Asnp.D217NQ9HBU6protein_codingtolerated(0.22)benign(0.223)TCGA-BH-A18V-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ETNK1SNVMissense_Mutationnovelc.745A>Cp.Lys249Glnp.K249QQ9HBU6protein_codingtolerated(0.12)benign(0.145)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
ETNK1insertionNonsense_Mutationnovelc.1338_1339insCAGCCAATTGGATGATACCAGCCGACATTGAGGGTGGp.Ala447GlnfsTer5p.A447Qfs*5Q9HBU6protein_codingTCGA-B6-A0IN-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
ETNK1SNVMissense_Mutationc.721N>Tp.His241Tyrp.H241YQ9HBU6protein_codingdeleterious(0.03)benign(0.356)TCGA-LP-A4AV-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ETNK1SNVMissense_Mutationnovelc.500N>Tp.Arg167Ilep.R167IQ9HBU6protein_codingdeleterious(0)probably_damaging(1)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
ETNK1SNVMissense_Mutationc.270G>Tp.Met90Ilep.M90IQ9HBU6protein_codingdeleterious_low_confidence(0.02)possibly_damaging(0.838)TCGA-DM-A288-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownPD
ETNK1deletionIn_Frame_Delc.28_30delTCCp.Ser10delp.S10delQ9HBU6protein_codingTCGA-F5-6810-01Colorectumrectum adenocarcinomaUnknownUnknownI/IIUnknownUnknownUnknown
ETNK1SNVMissense_Mutationnovelc.966N>Cp.Gln322Hisp.Q322HQ9HBU6protein_codingdeleterious(0.04)benign(0.14)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ETNK1SNVMissense_Mutationc.593N>Cp.Leu198Prop.L198PQ9HBU6protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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