![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EMC10 |
Gene summary for EMC10 |
![]() |
Gene information | Species | Human | Gene symbol | EMC10 | Gene ID | 284361 |
Gene name | ER membrane protein complex subunit 10 | |
Gene Alias | C19orf63 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q5UCC4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284361 | EMC10 | P126T-E | Human | Esophagus | ESCC | 2.48e-19 | 1.67e+00 | 0.1125 |
284361 | EMC10 | P127T-E | Human | Esophagus | ESCC | 6.37e-30 | 5.80e-01 | 0.0826 |
284361 | EMC10 | P128T-E | Human | Esophagus | ESCC | 9.53e-57 | 1.93e+00 | 0.1241 |
284361 | EMC10 | P130T-E | Human | Esophagus | ESCC | 9.51e-50 | 1.13e+00 | 0.1676 |
284361 | EMC10 | S43 | Human | Liver | Cirrhotic | 8.98e-08 | -1.53e-01 | -0.0187 |
284361 | EMC10 | HCC1_Meng | Human | Liver | HCC | 2.53e-91 | 8.90e-02 | 0.0246 |
284361 | EMC10 | HCC2_Meng | Human | Liver | HCC | 4.71e-42 | 1.58e-01 | 0.0107 |
284361 | EMC10 | cirrhotic1 | Human | Liver | Cirrhotic | 7.28e-10 | 2.63e-01 | 0.0202 |
284361 | EMC10 | cirrhotic2 | Human | Liver | Cirrhotic | 1.26e-12 | 2.08e-01 | 0.0201 |
284361 | EMC10 | cirrhotic3 | Human | Liver | Cirrhotic | 6.00e-07 | 1.26e-01 | 0.0215 |
284361 | EMC10 | HCC1 | Human | Liver | HCC | 2.96e-03 | 3.49e+00 | 0.5336 |
284361 | EMC10 | HCC2 | Human | Liver | HCC | 7.86e-31 | 5.04e+00 | 0.5341 |
284361 | EMC10 | Pt13.b | Human | Liver | HCC | 1.48e-24 | 1.84e-01 | 0.0251 |
284361 | EMC10 | Pt14.a | Human | Liver | HCC | 3.83e-02 | 1.77e-01 | 0.0169 |
284361 | EMC10 | S014 | Human | Liver | HCC | 5.07e-30 | 1.53e+00 | 0.2254 |
284361 | EMC10 | S015 | Human | Liver | HCC | 9.10e-32 | 2.35e+00 | 0.2375 |
284361 | EMC10 | S016 | Human | Liver | HCC | 3.39e-37 | 1.80e+00 | 0.2243 |
284361 | EMC10 | S027 | Human | Liver | HCC | 1.55e-15 | 1.54e+00 | 0.2446 |
284361 | EMC10 | S028 | Human | Liver | HCC | 4.45e-38 | 1.83e+00 | 0.2503 |
284361 | EMC10 | S029 | Human | Liver | HCC | 6.18e-32 | 1.82e+00 | 0.2581 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:009013014 | Endometrium | AEH | tissue migration | 73/2100 | 365/18723 | 5.79e-07 | 2.20e-05 | 73 |
GO:009013214 | Endometrium | AEH | epithelium migration | 72/2100 | 360/18723 | 6.90e-07 | 2.55e-05 | 72 |
GO:001063114 | Endometrium | AEH | epithelial cell migration | 71/2100 | 357/18723 | 1.02e-06 | 3.52e-05 | 71 |
GO:001063214 | Endometrium | AEH | regulation of epithelial cell migration | 60/2100 | 292/18723 | 2.31e-06 | 6.77e-05 | 60 |
GO:00506788 | Endometrium | AEH | regulation of epithelial cell proliferation | 73/2100 | 381/18723 | 3.04e-06 | 8.44e-05 | 73 |
GO:001063410 | Endometrium | AEH | positive regulation of epithelial cell migration | 41/2100 | 176/18723 | 3.79e-06 | 1.01e-04 | 41 |
GO:00514039 | Endometrium | AEH | stress-activated MAPK cascade | 50/2100 | 239/18723 | 9.33e-06 | 2.18e-04 | 50 |
GO:00310989 | Endometrium | AEH | stress-activated protein kinase signaling cascade | 51/2100 | 247/18723 | 1.12e-05 | 2.52e-04 | 51 |
GO:00328728 | Endometrium | AEH | regulation of stress-activated MAPK cascade | 42/2100 | 192/18723 | 1.53e-05 | 3.23e-04 | 42 |
GO:00380665 | Endometrium | AEH | p38MAPK cascade | 18/2100 | 55/18723 | 1.77e-05 | 3.65e-04 | 18 |
GO:00435428 | Endometrium | AEH | endothelial cell migration | 55/2100 | 279/18723 | 2.11e-05 | 4.15e-04 | 55 |
GO:00105955 | Endometrium | AEH | positive regulation of endothelial cell migration | 32/2100 | 133/18723 | 2.12e-05 | 4.15e-04 | 32 |
GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
GO:00703028 | Endometrium | AEH | regulation of stress-activated protein kinase signaling cascade | 42/2100 | 195/18723 | 2.27e-05 | 4.35e-04 | 42 |
GO:00105945 | Endometrium | AEH | regulation of endothelial cell migration | 47/2100 | 232/18723 | 4.02e-05 | 6.91e-04 | 47 |
GO:00506795 | Endometrium | AEH | positive regulation of epithelial cell proliferation | 43/2100 | 207/18723 | 4.55e-05 | 7.61e-04 | 43 |
GO:009015010 | Endometrium | AEH | establishment of protein localization to membrane | 51/2100 | 260/18723 | 4.74e-05 | 7.85e-04 | 51 |
GO:19007443 | Endometrium | AEH | regulation of p38MAPK cascade | 15/2100 | 47/18723 | 1.21e-04 | 1.67e-03 | 15 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC10 | SNV | Missense_Mutation | novel | c.664N>C | p.Phe222Leu | p.F222L | Q5UCC4 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
EMC10 | SNV | Missense_Mutation | rs369893864 | c.551N>T | p.Ser184Leu | p.S184L | Q5UCC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.508) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
EMC10 | SNV | Missense_Mutation | rs200217945 | c.610C>T | p.Arg204Cys | p.R204C | Q5UCC4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EMC10 | SNV | Missense_Mutation | rs369893864 | c.551C>T | p.Ser184Leu | p.S184L | Q5UCC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.508) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EMC10 | SNV | Missense_Mutation | novel | c.526N>A | p.Val176Met | p.V176M | Q5UCC4 | protein_coding | tolerated(0.1) | probably_damaging(0.916) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EMC10 | SNV | Missense_Mutation | rs200217945 | c.610N>T | p.Arg204Cys | p.R204C | Q5UCC4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
EMC10 | SNV | Missense_Mutation | c.487N>G | p.Thr163Ala | p.T163A | Q5UCC4 | protein_coding | tolerated(0.13) | benign(0.067) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EMC10 | deletion | Frame_Shift_Del | novel | c.578delN | p.Pro194GlnfsTer45 | p.P194Qfs*45 | Q5UCC4 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EMC10 | SNV | Missense_Mutation | novel | c.152C>T | p.Thr51Met | p.T51M | Q5UCC4 | protein_coding | tolerated(0.09) | possibly_damaging(0.556) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EMC10 | SNV | Missense_Mutation | novel | c.370G>A | p.Ala124Thr | p.A124T | Q5UCC4 | protein_coding | tolerated(0.37) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |