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Gene: DNAJC2 |
Gene summary for DNAJC2 |
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Gene information | Species | Human | Gene symbol | DNAJC2 | Gene ID | 27000 |
Gene name | DnaJ heat shock protein family (Hsp40) member C2 | |
Gene Alias | MPHOSPH11 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99543 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27000 | DNAJC2 | C57 | Human | Oral cavity | OSCC | 9.81e-16 | 6.55e-01 | 0.1679 |
27000 | DNAJC2 | C06 | Human | Oral cavity | OSCC | 8.72e-10 | 1.44e+00 | 0.2699 |
27000 | DNAJC2 | C08 | Human | Oral cavity | OSCC | 7.22e-57 | 1.10e+00 | 0.1919 |
27000 | DNAJC2 | C09 | Human | Oral cavity | OSCC | 1.60e-04 | 3.53e-01 | 0.1431 |
27000 | DNAJC2 | LN22 | Human | Oral cavity | OSCC | 2.44e-12 | 1.25e+00 | 0.1733 |
27000 | DNAJC2 | LN38 | Human | Oral cavity | OSCC | 8.16e-10 | 1.71e+00 | 0.168 |
27000 | DNAJC2 | LN46 | Human | Oral cavity | OSCC | 7.87e-09 | 5.55e-01 | 0.1666 |
27000 | DNAJC2 | LP15 | Human | Oral cavity | LP | 3.23e-04 | 1.25e+00 | 0.2174 |
27000 | DNAJC2 | SYSMH1 | Human | Oral cavity | OSCC | 6.37e-07 | 3.55e-01 | 0.1127 |
27000 | DNAJC2 | SYSMH2 | Human | Oral cavity | OSCC | 2.95e-29 | 9.63e-01 | 0.2326 |
27000 | DNAJC2 | SYSMH3 | Human | Oral cavity | OSCC | 1.12e-37 | 9.93e-01 | 0.2442 |
27000 | DNAJC2 | SYSMH4 | Human | Oral cavity | OSCC | 3.46e-06 | 9.65e-02 | 0.1226 |
27000 | DNAJC2 | SYSMH5 | Human | Oral cavity | OSCC | 7.15e-05 | 1.89e-01 | 0.0647 |
27000 | DNAJC2 | SYSMH6 | Human | Oral cavity | OSCC | 1.46e-06 | 3.70e-01 | 0.1275 |
27000 | DNAJC2 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.45e-12 | 5.78e-01 | -0.1972 |
27000 | DNAJC2 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 1.42e-08 | 4.43e-01 | -0.2126 |
27000 | DNAJC2 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 4.20e-06 | 6.30e-01 | -0.2247 |
27000 | DNAJC2 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 1.26e-06 | 9.18e-01 | -0.2027 |
27000 | DNAJC2 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 8.18e-04 | 4.17e-01 | -0.1833 |
27000 | DNAJC2 | 047563_1562-all-cells | Human | Prostate | BPH | 1.57e-07 | -3.64e-02 | 0.0791 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
GO:003460520 | Esophagus | HGIN | cellular response to heat | 30/2587 | 69/18723 | 1.78e-09 | 1.35e-07 | 30 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000645820 | Esophagus | HGIN | 'de novo' protein folding | 19/2587 | 43/18723 | 1.25e-06 | 4.83e-05 | 19 |
GO:000940819 | Esophagus | HGIN | response to heat | 34/2587 | 110/18723 | 2.94e-06 | 1.01e-04 | 34 |
GO:005105214 | Esophagus | HGIN | regulation of DNA metabolic process | 79/2587 | 359/18723 | 1.38e-05 | 3.85e-04 | 79 |
GO:007189710 | Esophagus | HGIN | DNA biosynthetic process | 44/2587 | 180/18723 | 8.97e-05 | 1.96e-03 | 44 |
GO:000926618 | Esophagus | HGIN | response to temperature stimulus | 42/2587 | 178/18723 | 2.91e-04 | 4.98e-03 | 42 |
GO:200027819 | Esophagus | HGIN | regulation of DNA biosynthetic process | 28/2587 | 106/18723 | 4.30e-04 | 6.47e-03 | 28 |
GO:19000344 | Esophagus | HGIN | regulation of cellular response to heat | 7/2587 | 17/18723 | 5.21e-03 | 4.30e-02 | 7 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:2000278110 | Esophagus | ESCC | regulation of DNA biosynthetic process | 81/8552 | 106/18723 | 9.81e-11 | 2.96e-09 | 81 |
GO:0061077110 | Esophagus | ESCC | chaperone-mediated protein folding | 56/8552 | 67/18723 | 1.52e-10 | 4.36e-09 | 56 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC2 | SNV | Missense_Mutation | c.1337N>T | p.Gly446Val | p.G446V | Q99543 | protein_coding | tolerated(0.22) | benign(0.036) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DNAJC2 | SNV | Missense_Mutation | novel | c.1633N>C | p.Glu545Gln | p.E545Q | Q99543 | protein_coding | deleterious(0.03) | benign(0.255) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJC2 | SNV | Missense_Mutation | c.214G>C | p.Glu72Gln | p.E72Q | Q99543 | protein_coding | tolerated(0.07) | probably_damaging(0.979) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAJC2 | deletion | Frame_Shift_Del | c.1196_1197delTC | p.Leu399HisfsTer21 | p.L399Hfs*21 | Q99543 | protein_coding | TCGA-A2-A0D3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |||
DNAJC2 | SNV | Missense_Mutation | novel | c.1234G>C | p.Glu412Gln | p.E412Q | Q99543 | protein_coding | tolerated(0.62) | benign(0.123) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
DNAJC2 | SNV | Missense_Mutation | c.1070N>T | p.Arg357Leu | p.R357L | Q99543 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAJC2 | SNV | Missense_Mutation | c.1860G>T | p.Lys620Asn | p.K620N | Q99543 | protein_coding | deleterious_low_confidence(0.01) | benign(0.224) | TCGA-A6-5664-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
DNAJC2 | SNV | Missense_Mutation | c.647N>A | p.Ser216Tyr | p.S216Y | Q99543 | protein_coding | deleterious(0) | possibly_damaging(0.768) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
DNAJC2 | SNV | Missense_Mutation | c.668C>A | p.Ser223Tyr | p.S223Y | Q99543 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAJC2 | SNV | Missense_Mutation | c.784N>A | p.Glu262Lys | p.E262K | Q99543 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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