Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CREB3L4_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CREB3L4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CREB3L4_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CREB3L4_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000698614 | Breast | IDC | response to unfolded protein | 30/1434 | 137/18723 | 1.24e-07 | 7.03e-06 | 30 |
GO:003596614 | Breast | IDC | response to topologically incorrect protein | 32/1434 | 159/18723 | 3.71e-07 | 1.85e-05 | 32 |
GO:003462013 | Breast | IDC | cellular response to unfolded protein | 23/1434 | 96/18723 | 6.73e-07 | 3.16e-05 | 23 |
GO:003497614 | Breast | IDC | response to endoplasmic reticulum stress | 43/1434 | 256/18723 | 8.42e-07 | 3.82e-05 | 43 |
GO:003596714 | Breast | IDC | cellular response to topologically incorrect protein | 24/1434 | 116/18723 | 6.27e-06 | 1.98e-04 | 24 |
GO:003096812 | Breast | IDC | endoplasmic reticulum unfolded protein response | 17/1434 | 74/18723 | 3.37e-05 | 7.79e-04 | 17 |
GO:000698622 | Breast | DCIS | response to unfolded protein | 30/1390 | 137/18723 | 6.24e-08 | 3.72e-06 | 30 |
GO:003596622 | Breast | DCIS | response to topologically incorrect protein | 32/1390 | 159/18723 | 1.84e-07 | 9.15e-06 | 32 |
GO:003497622 | Breast | DCIS | response to endoplasmic reticulum stress | 43/1390 | 256/18723 | 3.65e-07 | 1.71e-05 | 43 |
GO:003462022 | Breast | DCIS | cellular response to unfolded protein | 23/1390 | 96/18723 | 3.90e-07 | 1.79e-05 | 23 |
GO:003596722 | Breast | DCIS | cellular response to topologically incorrect protein | 24/1390 | 116/18723 | 3.68e-06 | 1.16e-04 | 24 |
GO:003096821 | Breast | DCIS | endoplasmic reticulum unfolded protein response | 17/1390 | 74/18723 | 2.26e-05 | 5.32e-04 | 17 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
GO:0035967111 | Esophagus | ESCC | cellular response to topologically incorrect protein | 90/8552 | 116/18723 | 1.94e-12 | 8.11e-11 | 90 |
GO:0034620111 | Esophagus | ESCC | cellular response to unfolded protein | 74/8552 | 96/18723 | 3.10e-10 | 8.66e-09 | 74 |
GO:003096818 | Esophagus | ESCC | endoplasmic reticulum unfolded protein response | 59/8552 | 74/18723 | 1.90e-09 | 4.36e-08 | 59 |
GO:003497620 | Oral cavity | OSCC | response to endoplasmic reticulum stress | 178/7305 | 256/18723 | 2.59e-23 | 6.06e-21 | 178 |
GO:003596620 | Oral cavity | OSCC | response to topologically incorrect protein | 117/7305 | 159/18723 | 6.93e-19 | 8.60e-17 | 117 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CREB3L4 | SNV | Missense_Mutation | novel | c.605N>G | p.Val202Gly | p.V202G | Q8TEY5 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | | c.806A>G | p.His269Arg | p.H269R | Q8TEY5 | protein_coding | tolerated(0.11) | benign(0.108) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | rs777111235 | c.458N>A | p.Cys153Tyr | p.C153Y | Q8TEY5 | protein_coding | tolerated(0.05) | benign(0.166) | TCGA-BH-A28Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | rs371608503 | c.584G>A | p.Arg195His | p.R195H | Q8TEY5 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | novel | c.793N>C | p.Glu265Gln | p.E265Q | Q8TEY5 | protein_coding | tolerated(0.35) | possibly_damaging(0.457) | TCGA-E2-A1LI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CREB3L4 | insertion | Frame_Shift_Ins | novel | c.99_100insATGTTGACCAGGCTGGTCTTGAACT | p.Pro34MetfsTer16 | p.P34Mfs*16 | Q8TEY5 | protein_coding | | | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CREB3L4 | insertion | Frame_Shift_Ins | novel | c.361_362insGTTTCCCGGAGCTTTCTCCCAGCTTCCCGGCGATTCATATT | p.Ala121GlyfsTer27 | p.A121Gfs*27 | Q8TEY5 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
CREB3L4 | SNV | Missense_Mutation | rs762042967 | c.517N>A | p.Val173Ile | p.V173I | Q8TEY5 | protein_coding | tolerated(0.36) | benign(0) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | | c.328N>T | p.Pro110Ser | p.P110S | Q8TEY5 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CREB3L4 | SNV | Missense_Mutation | novel | c.586N>G | p.Leu196Val | p.L196V | Q8TEY5 | protein_coding | deleterious(0) | possibly_damaging(0.727) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |