![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLUH |
Gene summary for CLUH |
![]() |
Gene information | Species | Human | Gene symbol | CLUH | Gene ID | 23277 |
Gene name | clustered mitochondria homolog | |
Gene Alias | CLU1 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | O75153 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23277 | CLUH | P126T-E | Human | Esophagus | ESCC | 2.91e-02 | 2.91e-01 | 0.1125 |
23277 | CLUH | P127T-E | Human | Esophagus | ESCC | 3.37e-11 | 5.28e-02 | 0.0826 |
23277 | CLUH | P128T-E | Human | Esophagus | ESCC | 6.31e-18 | 6.96e-01 | 0.1241 |
23277 | CLUH | P130T-E | Human | Esophagus | ESCC | 8.36e-39 | 7.38e-01 | 0.1676 |
23277 | CLUH | S43 | Human | Liver | Cirrhotic | 2.21e-04 | 1.41e-02 | -0.0187 |
23277 | CLUH | HCC1_Meng | Human | Liver | HCC | 3.10e-35 | -1.39e-03 | 0.0246 |
23277 | CLUH | HCC2_Meng | Human | Liver | HCC | 2.66e-08 | 5.68e-02 | 0.0107 |
23277 | CLUH | HCC1 | Human | Liver | HCC | 2.26e-04 | 2.83e+00 | 0.5336 |
23277 | CLUH | HCC2 | Human | Liver | HCC | 2.66e-16 | 4.04e+00 | 0.5341 |
23277 | CLUH | Pt14.a | Human | Liver | HCC | 4.24e-02 | 2.73e-01 | 0.0169 |
23277 | CLUH | S027 | Human | Liver | HCC | 4.26e-04 | 5.81e-01 | 0.2446 |
23277 | CLUH | S028 | Human | Liver | HCC | 2.57e-14 | 6.54e-01 | 0.2503 |
23277 | CLUH | S029 | Human | Liver | HCC | 8.70e-10 | 5.96e-01 | 0.2581 |
23277 | CLUH | C04 | Human | Oral cavity | OSCC | 5.20e-11 | 8.55e-01 | 0.2633 |
23277 | CLUH | C21 | Human | Oral cavity | OSCC | 2.69e-17 | 5.55e-01 | 0.2678 |
23277 | CLUH | C30 | Human | Oral cavity | OSCC | 2.67e-39 | 1.56e+00 | 0.3055 |
23277 | CLUH | C43 | Human | Oral cavity | OSCC | 4.60e-04 | 1.68e-01 | 0.1704 |
23277 | CLUH | C51 | Human | Oral cavity | OSCC | 3.41e-10 | 6.76e-01 | 0.2674 |
23277 | CLUH | C08 | Human | Oral cavity | OSCC | 5.35e-05 | 1.95e-01 | 0.1919 |
23277 | CLUH | LN22 | Human | Oral cavity | OSCC | 1.44e-02 | 6.40e-01 | 0.1733 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516463 | Esophagus | ESCC | mitochondrion localization | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
GO:0051646 | Liver | HCC | mitochondrion localization | 34/7958 | 50/18723 | 2.38e-04 | 1.79e-03 | 34 |
GO:0048311 | Liver | HCC | mitochondrion distribution | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:00516462 | Oral cavity | OSCC | mitochondrion localization | 28/7305 | 50/18723 | 1.10e-02 | 3.72e-02 | 28 |
GO:005164611 | Skin | cSCC | mitochondrion localization | 22/4864 | 50/18723 | 4.31e-03 | 2.27e-02 | 22 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLUH | SNV | Missense_Mutation | c.1260N>G | p.Ile420Met | p.I420M | O75153 | protein_coding | deleterious(0.03) | probably_damaging(0.955) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CLUH | SNV | Missense_Mutation | novel | c.3835N>T | p.Pro1279Ser | p.P1279S | O75153 | protein_coding | tolerated_low_confidence(0.39) | benign(0) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLUH | SNV | Missense_Mutation | c.3860N>T | p.Ala1287Val | p.A1287V | O75153 | protein_coding | tolerated_low_confidence(0.29) | benign(0.007) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | c.160N>A | p.Ala54Thr | p.A54T | O75153 | protein_coding | tolerated(0.19) | benign(0.102) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | c.2651N>T | p.Thr884Ile | p.T884I | O75153 | protein_coding | deleterious(0.01) | benign(0.304) | TCGA-E2-A14Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CLUH | SNV | Missense_Mutation | novel | c.3016A>G | p.Asn1006Asp | p.N1006D | O75153 | protein_coding | deleterious(0.01) | possibly_damaging(0.722) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
CLUH | SNV | Missense_Mutation | c.1810N>A | p.Leu604Met | p.L604M | O75153 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
CLUH | deletion | Frame_Shift_Del | novel | c.1768_1810delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Arg590CysfsTer18 | p.R590Cfs*18 | O75153 | protein_coding | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | ||
CLUH | insertion | Frame_Shift_Ins | novel | c.1022_1023insTAAAA | p.Ser342LysfsTer66 | p.S342Kfs*66 | O75153 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
CLUH | SNV | Missense_Mutation | novel | c.3147N>C | p.Met1049Ile | p.M1049I | O75153 | protein_coding | tolerated(0.24) | benign(0.147) | TCGA-MA-AA3W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |