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Gene: CLNS1A |
Gene summary for CLNS1A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CLNS1A | Gene ID | 1207 |
| Gene name | chloride nucleotide-sensitive channel 1A | |
| Gene Alias | CLCI | |
| Cytomap | 11q14.1 | |
| Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P54105 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1207 | CLNS1A | P128T-E | Human | Esophagus | ESCC | 8.83e-66 | 2.95e+00 | 0.1241 |
| 1207 | CLNS1A | P130T-E | Human | Esophagus | ESCC | 5.18e-83 | 2.32e+00 | 0.1676 |
| 1207 | CLNS1A | S43 | Human | Liver | Cirrhotic | 5.11e-09 | -2.44e-01 | -0.0187 |
| 1207 | CLNS1A | HCC1_Meng | Human | Liver | HCC | 3.98e-63 | 4.52e-01 | 0.0246 |
| 1207 | CLNS1A | HCC2_Meng | Human | Liver | HCC | 9.31e-26 | 6.85e-02 | 0.0107 |
| 1207 | CLNS1A | cirrhotic1 | Human | Liver | Cirrhotic | 9.91e-07 | 1.41e-01 | 0.0202 |
| 1207 | CLNS1A | cirrhotic2 | Human | Liver | Cirrhotic | 2.69e-05 | 2.11e-01 | 0.0201 |
| 1207 | CLNS1A | cirrhotic3 | Human | Liver | Cirrhotic | 6.80e-04 | 4.02e-02 | 0.0215 |
| 1207 | CLNS1A | HCC1 | Human | Liver | HCC | 3.59e-05 | 3.24e+00 | 0.5336 |
| 1207 | CLNS1A | HCC2 | Human | Liver | HCC | 2.28e-03 | 2.57e+00 | 0.5341 |
| 1207 | CLNS1A | Pt13.b | Human | Liver | HCC | 1.36e-22 | 2.09e-01 | 0.0251 |
| 1207 | CLNS1A | Pt14.a | Human | Liver | HCC | 2.82e-05 | 2.37e-01 | 0.0169 |
| 1207 | CLNS1A | S014 | Human | Liver | HCC | 6.82e-32 | 1.49e+00 | 0.2254 |
| 1207 | CLNS1A | S015 | Human | Liver | HCC | 2.34e-21 | 1.65e+00 | 0.2375 |
| 1207 | CLNS1A | S016 | Human | Liver | HCC | 2.50e-30 | 1.57e+00 | 0.2243 |
| 1207 | CLNS1A | S027 | Human | Liver | HCC | 1.72e-13 | 1.84e+00 | 0.2446 |
| 1207 | CLNS1A | S028 | Human | Liver | HCC | 7.12e-30 | 2.00e+00 | 0.2503 |
| 1207 | CLNS1A | S029 | Human | Liver | HCC | 8.70e-31 | 2.43e+00 | 0.2581 |
| 1207 | CLNS1A | C04 | Human | Oral cavity | OSCC | 2.69e-43 | 2.21e+00 | 0.2633 |
| 1207 | CLNS1A | C21 | Human | Oral cavity | OSCC | 1.07e-77 | 3.54e+00 | 0.2678 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
| GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
| GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
| GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
| GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
| GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
| GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
| GO:00003873 | Breast | Precancer | spliceosomal snRNP assembly | 10/1080 | 50/18723 | 4.86e-04 | 6.35e-03 | 10 |
| GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
| GO:007182614 | Breast | IDC | ribonucleoprotein complex subunit organization | 52/1434 | 227/18723 | 5.18e-13 | 1.21e-10 | 52 |
| GO:002261814 | Breast | IDC | ribonucleoprotein complex assembly | 51/1434 | 220/18723 | 5.32e-13 | 1.21e-10 | 51 |
| GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
| GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
| GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
| GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
| GO:000038711 | Breast | IDC | spliceosomal snRNP assembly | 11/1434 | 50/18723 | 1.18e-03 | 1.28e-02 | 11 |
| GO:00325358 | Breast | IDC | regulation of cellular component size | 45/1434 | 383/18723 | 2.72e-03 | 2.41e-02 | 45 |
| GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
| GO:007182624 | Breast | DCIS | ribonucleoprotein complex subunit organization | 52/1390 | 227/18723 | 1.54e-13 | 3.95e-11 | 52 |
| GO:002261824 | Breast | DCIS | ribonucleoprotein complex assembly | 51/1390 | 220/18723 | 1.60e-13 | 3.95e-11 | 51 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CLNS1A | SNV | Missense_Mutation | rs144382400 | c.442N>A | p.Asp148Asn | p.D148N | P54105 | protein_coding | tolerated(0.23) | benign(0.011) | TCGA-E2-A1B0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
| CLNS1A | deletion | Frame_Shift_Del | novel | c.535delN | p.Ala179GlnfsTer10 | p.A179Qfs*10 | P54105 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| CLNS1A | SNV | Missense_Mutation | c.192N>A | p.His64Gln | p.H64Q | P54105 | protein_coding | deleterious(0.03) | benign(0.355) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CLNS1A | SNV | Missense_Mutation | c.232N>G | p.Leu78Val | p.L78V | P54105 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| CLNS1A | SNV | Missense_Mutation | c.677T>C | p.Val226Ala | p.V226A | P54105 | protein_coding | tolerated(0.14) | possibly_damaging(0.611) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| CLNS1A | SNV | Missense_Mutation | rs373008022 | c.209G>A | p.Arg70Gln | p.R70Q | P54105 | protein_coding | tolerated(0.51) | benign(0.086) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| CLNS1A | SNV | Missense_Mutation | c.558G>T | p.Glu186Asp | p.E186D | P54105 | protein_coding | tolerated(0.16) | possibly_damaging(0.777) | TCGA-AG-3732-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | SD | |
| CLNS1A | SNV | Missense_Mutation | novel | c.667A>G | p.Thr223Ala | p.T223A | P54105 | protein_coding | tolerated(0.59) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CLNS1A | SNV | Missense_Mutation | c.693N>T | p.Glu231Asp | p.E231D | P54105 | protein_coding | tolerated(0.27) | benign(0.238) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CLNS1A | SNV | Missense_Mutation | rs779459403 | c.391G>A | p.Glu131Lys | p.E131K | P54105 | protein_coding | tolerated(0.07) | benign(0.029) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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