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Gene: CHTOP |
Gene summary for CHTOP |
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Gene information | Species | Human | Gene symbol | CHTOP | Gene ID | 26097 |
Gene name | chromatin target of PRMT1 | |
Gene Alias | C10orf77 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q9Y3Y2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26097 | CHTOP | C04 | Human | Oral cavity | OSCC | 3.48e-32 | 1.56e+00 | 0.2633 |
26097 | CHTOP | C21 | Human | Oral cavity | OSCC | 2.29e-56 | 1.60e+00 | 0.2678 |
26097 | CHTOP | C30 | Human | Oral cavity | OSCC | 3.07e-50 | 2.08e+00 | 0.3055 |
26097 | CHTOP | C38 | Human | Oral cavity | OSCC | 1.21e-15 | 1.69e+00 | 0.172 |
26097 | CHTOP | C43 | Human | Oral cavity | OSCC | 5.95e-15 | 4.71e-01 | 0.1704 |
26097 | CHTOP | C46 | Human | Oral cavity | OSCC | 1.26e-23 | 7.30e-01 | 0.1673 |
26097 | CHTOP | C51 | Human | Oral cavity | OSCC | 7.86e-14 | 9.70e-01 | 0.2674 |
26097 | CHTOP | C57 | Human | Oral cavity | OSCC | 5.35e-41 | 1.21e+00 | 0.1679 |
26097 | CHTOP | C06 | Human | Oral cavity | OSCC | 3.12e-10 | 1.56e+00 | 0.2699 |
26097 | CHTOP | C08 | Human | Oral cavity | OSCC | 5.37e-30 | 8.45e-01 | 0.1919 |
26097 | CHTOP | C09 | Human | Oral cavity | OSCC | 5.82e-13 | 5.17e-01 | 0.1431 |
26097 | CHTOP | LN22 | Human | Oral cavity | OSCC | 1.83e-05 | 1.09e+00 | 0.1733 |
26097 | CHTOP | LN38 | Human | Oral cavity | OSCC | 6.67e-08 | 1.40e+00 | 0.168 |
26097 | CHTOP | LN46 | Human | Oral cavity | OSCC | 2.53e-10 | 6.91e-01 | 0.1666 |
26097 | CHTOP | LP15 | Human | Oral cavity | LP | 1.06e-05 | 1.13e+00 | 0.2174 |
26097 | CHTOP | LP17 | Human | Oral cavity | LP | 9.22e-05 | 9.38e-01 | 0.2349 |
26097 | CHTOP | SYSMH1 | Human | Oral cavity | OSCC | 1.85e-08 | 3.69e-01 | 0.1127 |
26097 | CHTOP | SYSMH2 | Human | Oral cavity | OSCC | 2.10e-20 | 6.72e-01 | 0.2326 |
26097 | CHTOP | SYSMH3 | Human | Oral cavity | OSCC | 3.73e-31 | 8.70e-01 | 0.2442 |
26097 | CHTOP | SYSMH4 | Human | Oral cavity | OSCC | 1.40e-02 | 1.25e-01 | 0.1226 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:007142612 | Esophagus | ESCC | ribonucleoprotein complex export from nucleus | 65/8552 | 76/18723 | 5.56e-13 | 2.50e-11 | 65 |
GO:000640512 | Esophagus | ESCC | RNA export from nucleus | 68/8552 | 84/18723 | 2.99e-11 | 1.01e-09 | 68 |
GO:00064064 | Esophagus | ESCC | mRNA export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:00714274 | Esophagus | ESCC | mRNA-containing ribonucleoprotein complex export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHTOP | SNV | Missense_Mutation | rs764039585 | c.605N>A | p.Arg202Gln | p.R202Q | Q9Y3Y2 | protein_coding | tolerated(0.35) | benign(0.116) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CHTOP | deletion | Frame_Shift_Del | c.235delC | p.Arg79AlafsTer11 | p.R79Afs*11 | Q9Y3Y2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
CHTOP | SNV | Missense_Mutation | c.323N>C | p.Ile108Thr | p.I108T | Q9Y3Y2 | protein_coding | tolerated(0.41) | benign(0.026) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CHTOP | SNV | Missense_Mutation | rs746372648 | c.119C>T | p.Ser40Leu | p.S40L | Q9Y3Y2 | protein_coding | deleterious(0.01) | benign(0.063) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHTOP | SNV | Missense_Mutation | novel | c.355C>T | p.Arg119Cys | p.R119C | Q9Y3Y2 | protein_coding | tolerated(0.07) | probably_damaging(0.942) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHTOP | SNV | Missense_Mutation | novel | c.64N>T | p.Arg22Cys | p.R22C | Q9Y3Y2 | protein_coding | deleterious(0.02) | possibly_damaging(0.616) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHTOP | SNV | Missense_Mutation | novel | c.508N>T | p.Arg170Cys | p.R170C | Q9Y3Y2 | protein_coding | tolerated(0.15) | probably_damaging(0.942) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHTOP | SNV | Missense_Mutation | c.225C>A | p.Ser75Arg | p.S75R | Q9Y3Y2 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHTOP | SNV | Missense_Mutation | c.700G>A | p.Ala234Thr | p.A234T | Q9Y3Y2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHTOP | SNV | Missense_Mutation | novel | c.236N>A | p.Arg79His | p.R79H | Q9Y3Y2 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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