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Gene: CHMP2A |
Gene summary for CHMP2A |
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Gene information | Species | Human | Gene symbol | CHMP2A | Gene ID | 27243 |
Gene name | charged multivesicular body protein 2A | |
Gene Alias | BC-2 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A024R4S0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27243 | CHMP2A | EEC-subject4 | Human | Endometrium | EEC | 4.04e-05 | -7.80e-02 | -0.2571 |
27243 | CHMP2A | EEC-subject5 | Human | Endometrium | EEC | 5.48e-08 | -4.18e-02 | -0.249 |
27243 | CHMP2A | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.62e-24 | -4.02e-01 | -0.1869 |
27243 | CHMP2A | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.18e-26 | -4.80e-01 | -0.1875 |
27243 | CHMP2A | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.63e-29 | -3.38e-01 | -0.1883 |
27243 | CHMP2A | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.47e-36 | -4.65e-01 | -0.1934 |
27243 | CHMP2A | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.08e-38 | -4.00e-01 | -0.1917 |
27243 | CHMP2A | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.75e-39 | -3.43e-01 | -0.1916 |
27243 | CHMP2A | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.38e-09 | -2.59e-01 | -0.1269 |
27243 | CHMP2A | LZE4T | Human | Esophagus | ESCC | 1.27e-12 | 5.60e-01 | 0.0811 |
27243 | CHMP2A | LZE5T | Human | Esophagus | ESCC | 4.18e-03 | 7.44e-01 | 0.0514 |
27243 | CHMP2A | LZE7T | Human | Esophagus | ESCC | 7.17e-15 | 1.43e+00 | 0.0667 |
27243 | CHMP2A | LZE8T | Human | Esophagus | ESCC | 5.38e-12 | 6.19e-01 | 0.067 |
27243 | CHMP2A | LZE20T | Human | Esophagus | ESCC | 7.21e-07 | 3.47e-01 | 0.0662 |
27243 | CHMP2A | LZE22D1 | Human | Esophagus | HGIN | 1.30e-08 | 3.01e-01 | 0.0595 |
27243 | CHMP2A | LZE22T | Human | Esophagus | ESCC | 2.19e-08 | 6.80e-01 | 0.068 |
27243 | CHMP2A | LZE24T | Human | Esophagus | ESCC | 1.19e-22 | 9.27e-01 | 0.0596 |
27243 | CHMP2A | LZE21T | Human | Esophagus | ESCC | 2.94e-03 | 7.58e-01 | 0.0655 |
27243 | CHMP2A | LZE6T | Human | Esophagus | ESCC | 1.90e-07 | 5.47e-01 | 0.0845 |
27243 | CHMP2A | P1T-E | Human | Esophagus | ESCC | 1.17e-19 | 1.25e+00 | 0.0875 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00507929 | Breast | Precancer | regulation of viral process | 27/1080 | 164/18723 | 7.59e-07 | 3.05e-05 | 27 |
GO:00439039 | Breast | Precancer | regulation of biological process involved in symbiotic interaction | 15/1080 | 72/18723 | 1.23e-05 | 3.17e-04 | 15 |
GO:19039009 | Breast | Precancer | regulation of viral life cycle | 23/1080 | 148/18723 | 1.31e-05 | 3.30e-04 | 23 |
GO:00485249 | Breast | Precancer | positive regulation of viral process | 12/1080 | 65/18723 | 3.00e-04 | 4.34e-03 | 12 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:19035434 | Breast | Precancer | positive regulation of exosomal secretion | 5/1080 | 15/18723 | 1.17e-03 | 1.26e-02 | 5 |
GO:19035416 | Breast | Precancer | regulation of exosomal secretion | 5/1080 | 17/18723 | 2.19e-03 | 2.06e-02 | 5 |
GO:19901826 | Breast | Precancer | exosomal secretion | 5/1080 | 20/18723 | 4.74e-03 | 3.61e-02 | 5 |
GO:19039026 | Breast | Precancer | positive regulation of viral life cycle | 6/1080 | 29/18723 | 5.49e-03 | 4.01e-02 | 6 |
GO:00977346 | Breast | Precancer | extracellular exosome biogenesis | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:005079214 | Breast | IDC | regulation of viral process | 36/1434 | 164/18723 | 6.55e-09 | 5.03e-07 | 36 |
GO:190390014 | Breast | IDC | regulation of viral life cycle | 30/1434 | 148/18723 | 7.25e-07 | 3.35e-05 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP2A | SNV | Missense_Mutation | novel | c.423N>C | p.Glu141Asp | p.E141D | O43633 | protein_coding | tolerated(0.06) | possibly_damaging(0.717) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.445G>A | p.Asp149Asn | p.D149N | O43633 | protein_coding | tolerated(0.09) | possibly_damaging(0.817) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.289N>G | p.Asn97Asp | p.N97D | O43633 | protein_coding | tolerated(0.41) | benign(0.021) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | rs376979258 | c.220C>T | p.Arg74Cys | p.R74C | O43633 | protein_coding | deleterious(0.01) | possibly_damaging(0.806) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHMP2A | SNV | Missense_Mutation | rs144804005 | c.539N>T | p.Ser180Leu | p.S180L | O43633 | protein_coding | tolerated(0.32) | benign(0.022) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CHMP2A | SNV | Missense_Mutation | novel | c.152N>T | p.Ala51Val | p.A51V | O43633 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | c.605C>T | p.Ala202Val | p.A202V | O43633 | protein_coding | tolerated(0.07) | benign(0.017) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2A | SNV | Missense_Mutation | novel | c.308N>C | p.Met103Thr | p.M103T | O43633 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.497A>C | p.Gln166Pro | p.Q166P | O43633 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.178N>T | p.Arg60Cys | p.R60C | O43633 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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