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Gene: CFAP97 |
Gene summary for CFAP97 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CFAP97 | Gene ID | 57587 |
| Gene name | cilia and flagella associated protein 97 | |
| Gene Alias | KIAA1430 | |
| Cytomap | 4q35.1 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9P2B7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57587 | CFAP97 | C04 | Human | Oral cavity | OSCC | 5.73e-12 | 6.98e-01 | 0.2633 |
| 57587 | CFAP97 | C21 | Human | Oral cavity | OSCC | 1.08e-29 | 1.24e+00 | 0.2678 |
| 57587 | CFAP97 | C30 | Human | Oral cavity | OSCC | 7.08e-16 | 9.50e-01 | 0.3055 |
| 57587 | CFAP97 | C38 | Human | Oral cavity | OSCC | 3.06e-02 | 5.87e-01 | 0.172 |
| 57587 | CFAP97 | C43 | Human | Oral cavity | OSCC | 9.13e-25 | 5.54e-01 | 0.1704 |
| 57587 | CFAP97 | C46 | Human | Oral cavity | OSCC | 7.92e-12 | 5.64e-01 | 0.1673 |
| 57587 | CFAP97 | C51 | Human | Oral cavity | OSCC | 8.32e-04 | 5.52e-01 | 0.2674 |
| 57587 | CFAP97 | C08 | Human | Oral cavity | OSCC | 1.71e-34 | 8.49e-01 | 0.1919 |
| 57587 | CFAP97 | C09 | Human | Oral cavity | OSCC | 2.01e-10 | 3.10e-01 | 0.1431 |
| 57587 | CFAP97 | LN22 | Human | Oral cavity | OSCC | 8.79e-04 | 4.81e-01 | 0.1733 |
| 57587 | CFAP97 | LN46 | Human | Oral cavity | OSCC | 4.31e-06 | 4.52e-01 | 0.1666 |
| 57587 | CFAP97 | SYSMH1 | Human | Oral cavity | OSCC | 7.76e-03 | 1.88e-01 | 0.1127 |
| 57587 | CFAP97 | SYSMH2 | Human | Oral cavity | OSCC | 8.05e-11 | 5.24e-01 | 0.2326 |
| 57587 | CFAP97 | SYSMH3 | Human | Oral cavity | OSCC | 1.35e-19 | 7.18e-01 | 0.2442 |
| 57587 | CFAP97 | SYSMH4 | Human | Oral cavity | OSCC | 1.36e-03 | 7.61e-02 | 0.1226 |
| 57587 | CFAP97 | male-WTA | Human | Thyroid | PTC | 6.03e-43 | 5.12e-01 | 0.1037 |
| 57587 | CFAP97 | PTC01 | Human | Thyroid | PTC | 1.56e-23 | 5.22e-01 | 0.1899 |
| 57587 | CFAP97 | PTC03 | Human | Thyroid | PTC | 2.86e-05 | 3.23e-01 | 0.1784 |
| 57587 | CFAP97 | PTC04 | Human | Thyroid | PTC | 7.57e-25 | 6.34e-01 | 0.1927 |
| 57587 | CFAP97 | PTC05 | Human | Thyroid | PTC | 2.60e-34 | 1.36e+00 | 0.2065 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CFAP97 | SNV | Missense_Mutation | rs781085964 | c.1205C>T | p.Ala402Val | p.A402V | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CFAP97 | SNV | Missense_Mutation | c.615N>T | p.Lys205Asn | p.K205N | Q9P2B7 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| CFAP97 | SNV | Missense_Mutation | c.608N>T | p.Ser203Leu | p.S203L | Q9P2B7 | protein_coding | tolerated(0.1) | benign(0.036) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| CFAP97 | insertion | Nonsense_Mutation | novel | c.825_826insCATTCCCAACAATAAAAAATATCTACTA | p.Asp276HisfsTer5 | p.D276Hfs*5 | Q9P2B7 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| CFAP97 | SNV | Missense_Mutation | rs373566490 | c.158N>T | p.Ser53Leu | p.S53L | Q9P2B7 | protein_coding | tolerated(0.61) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| CFAP97 | SNV | Missense_Mutation | rs777547282 | c.1397N>A | p.Arg466His | p.R466H | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| CFAP97 | SNV | Missense_Mutation | c.775N>C | p.Ser259Pro | p.S259P | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| CFAP97 | SNV | Missense_Mutation | c.53N>G | p.Asp18Gly | p.D18G | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| CFAP97 | SNV | Missense_Mutation | novel | c.1069N>A | p.Asp357Asn | p.D357N | Q9P2B7 | protein_coding | tolerated(0.11) | probably_damaging(0.911) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| CFAP97 | SNV | Missense_Mutation | novel | c.495N>T | p.Lys165Asn | p.K165N | Q9P2B7 | protein_coding | deleterious(0.01) | benign(0.071) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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