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Gene: CFAP36 |
Gene summary for CFAP36 |
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Gene information | Species | Human | Gene symbol | CFAP36 | Gene ID | 112942 |
Gene name | cilia and flagella associated protein 36 | |
Gene Alias | BARTL1 | |
Cytomap | 2p16.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96G28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112942 | CFAP36 | C30 | Human | Oral cavity | OSCC | 6.78e-33 | 1.41e+00 | 0.3055 |
112942 | CFAP36 | C38 | Human | Oral cavity | OSCC | 1.08e-12 | 1.25e+00 | 0.172 |
112942 | CFAP36 | C43 | Human | Oral cavity | OSCC | 3.37e-07 | 2.08e-01 | 0.1704 |
112942 | CFAP36 | C46 | Human | Oral cavity | OSCC | 1.04e-22 | 5.86e-01 | 0.1673 |
112942 | CFAP36 | C57 | Human | Oral cavity | OSCC | 2.56e-02 | 2.58e-01 | 0.1679 |
112942 | CFAP36 | C08 | Human | Oral cavity | OSCC | 1.35e-28 | 7.07e-01 | 0.1919 |
112942 | CFAP36 | C09 | Human | Oral cavity | OSCC | 2.11e-11 | 4.67e-01 | 0.1431 |
112942 | CFAP36 | LN22 | Human | Oral cavity | OSCC | 4.24e-09 | 9.72e-01 | 0.1733 |
112942 | CFAP36 | LN38 | Human | Oral cavity | OSCC | 7.89e-04 | 1.40e+00 | 0.168 |
112942 | CFAP36 | LN46 | Human | Oral cavity | OSCC | 1.77e-12 | 6.26e-01 | 0.1666 |
112942 | CFAP36 | LP15 | Human | Oral cavity | LP | 3.73e-02 | 7.15e-01 | 0.2174 |
112942 | CFAP36 | SYSMH2 | Human | Oral cavity | OSCC | 1.09e-04 | 4.32e-01 | 0.2326 |
112942 | CFAP36 | SYSMH3 | Human | Oral cavity | OSCC | 1.54e-08 | 4.84e-01 | 0.2442 |
112942 | CFAP36 | SYSMH6 | Human | Oral cavity | OSCC | 5.22e-08 | 2.54e-01 | 0.1275 |
112942 | CFAP36 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 7.64e-03 | -2.97e-01 | 0.02 |
112942 | CFAP36 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 2.18e-03 | -3.45e-01 | 0.0267 |
112942 | CFAP36 | PTCwithHT_8 | Human | Thyroid | HT | 4.73e-02 | -2.74e-01 | 0.0351 |
112942 | CFAP36 | male-WTA | Human | Thyroid | PTC | 1.98e-43 | 1.72e-01 | 0.1037 |
112942 | CFAP36 | PTC01 | Human | Thyroid | PTC | 3.21e-10 | 2.04e-01 | 0.1899 |
112942 | CFAP36 | PTC04 | Human | Thyroid | PTC | 3.52e-06 | 2.34e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP36 | SNV | Missense_Mutation | rs377625368 | c.745A>G | p.Ile249Val | p.I249V | Q96G28 | protein_coding | tolerated(1) | benign(0) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
CFAP36 | SNV | Missense_Mutation | c.617N>T | p.Ser206Leu | p.S206L | Q96G28 | protein_coding | tolerated(0.41) | benign(0.022) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CFAP36 | SNV | Missense_Mutation | novel | c.658N>A | p.Ala220Thr | p.A220T | Q96G28 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CFAP36 | SNV | Missense_Mutation | c.674A>T | p.Asn225Ile | p.N225I | Q96G28 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CFAP36 | SNV | Missense_Mutation | rs763494988 | c.452N>A | p.Arg151Gln | p.R151Q | Q96G28 | protein_coding | tolerated(0.05) | possibly_damaging(0.446) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.671A>C | p.Asn224Thr | p.N224T | Q96G28 | protein_coding | tolerated(0.46) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CFAP36 | SNV | Missense_Mutation | rs763494988 | c.452N>A | p.Arg151Gln | p.R151Q | Q96G28 | protein_coding | tolerated(0.05) | possibly_damaging(0.446) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.734N>T | p.Ala245Val | p.A245V | Q96G28 | protein_coding | tolerated(0.13) | benign(0.049) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.500N>A | p.Gly167Asp | p.G167D | Q96G28 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | c.862G>T | p.Val288Leu | p.V288L | Q96G28 | protein_coding | tolerated(0.25) | benign(0.014) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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