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Gene: CBX3 |
Gene summary for CBX3 |
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Gene information | Species | Human | Gene symbol | CBX3 | Gene ID | 11335 |
Gene name | chromobox 3 | |
Gene Alias | HECH | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A4D177 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11335 | CBX3 | P15T-E | Human | Esophagus | ESCC | 1.86e-42 | 1.26e+00 | 0.1149 |
11335 | CBX3 | P16T-E | Human | Esophagus | ESCC | 4.16e-54 | 1.47e+00 | 0.1153 |
11335 | CBX3 | P17T-E | Human | Esophagus | ESCC | 1.40e-23 | 1.71e+00 | 0.1278 |
11335 | CBX3 | P19T-E | Human | Esophagus | ESCC | 3.32e-10 | 2.35e+00 | 0.1662 |
11335 | CBX3 | P20T-E | Human | Esophagus | ESCC | 4.22e-34 | 1.18e+00 | 0.1124 |
11335 | CBX3 | P21T-E | Human | Esophagus | ESCC | 4.20e-58 | 1.52e+00 | 0.1617 |
11335 | CBX3 | P22T-E | Human | Esophagus | ESCC | 5.70e-56 | 1.40e+00 | 0.1236 |
11335 | CBX3 | P23T-E | Human | Esophagus | ESCC | 3.27e-38 | 1.24e+00 | 0.108 |
11335 | CBX3 | P24T-E | Human | Esophagus | ESCC | 5.40e-44 | 1.33e+00 | 0.1287 |
11335 | CBX3 | P26T-E | Human | Esophagus | ESCC | 2.44e-68 | 1.60e+00 | 0.1276 |
11335 | CBX3 | P27T-E | Human | Esophagus | ESCC | 8.35e-32 | 1.09e+00 | 0.1055 |
11335 | CBX3 | P28T-E | Human | Esophagus | ESCC | 4.86e-78 | 1.88e+00 | 0.1149 |
11335 | CBX3 | P30T-E | Human | Esophagus | ESCC | 1.91e-38 | 1.95e+00 | 0.137 |
11335 | CBX3 | P31T-E | Human | Esophagus | ESCC | 2.68e-68 | 1.65e+00 | 0.1251 |
11335 | CBX3 | P32T-E | Human | Esophagus | ESCC | 5.28e-65 | 1.82e+00 | 0.1666 |
11335 | CBX3 | P36T-E | Human | Esophagus | ESCC | 6.16e-19 | 1.02e+00 | 0.1187 |
11335 | CBX3 | P37T-E | Human | Esophagus | ESCC | 2.55e-59 | 1.97e+00 | 0.1371 |
11335 | CBX3 | P38T-E | Human | Esophagus | ESCC | 5.36e-18 | 1.04e+00 | 0.127 |
11335 | CBX3 | P39T-E | Human | Esophagus | ESCC | 5.37e-24 | 7.86e-01 | 0.0894 |
11335 | CBX3 | P40T-E | Human | Esophagus | ESCC | 2.05e-20 | 8.54e-01 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485117 | Breast | IDC | rhythmic process | 38/1434 | 298/18723 | 1.34e-03 | 1.39e-02 | 38 |
GO:004851113 | Breast | DCIS | rhythmic process | 37/1390 | 298/18723 | 1.44e-03 | 1.47e-02 | 37 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00485112 | Colorectum | MSS | rhythmic process | 89/3467 | 298/18723 | 1.17e-06 | 3.96e-05 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00485113 | Colorectum | FAP | rhythmic process | 72/2622 | 298/18723 | 1.67e-06 | 6.99e-05 | 72 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00485114 | Colorectum | CRC | rhythmic process | 64/2078 | 298/18723 | 1.43e-07 | 1.62e-05 | 64 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00485119 | Endometrium | AEH | rhythmic process | 67/2100 | 298/18723 | 1.69e-08 | 1.04e-06 | 67 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:004851114 | Endometrium | EEC | rhythmic process | 67/2168 | 298/18723 | 5.86e-08 | 3.11e-06 | 67 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:004851118 | Esophagus | ESCC | rhythmic process | 164/8552 | 298/18723 | 6.80e-04 | 3.57e-03 | 164 |
GO:004851111 | Liver | Cirrhotic | rhythmic process | 103/4634 | 298/18723 | 8.47e-05 | 9.19e-04 | 103 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0513144 | Breast | DCIS | Shigellosis | 46/846 | 247/8465 | 2.06e-05 | 2.38e-04 | 1.75e-04 | 46 |
hsa0513154 | Breast | DCIS | Shigellosis | 46/846 | 247/8465 | 2.06e-05 | 2.38e-04 | 1.75e-04 | 46 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051316 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa051317 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051319 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa0513110 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa0513111 | Colorectum | CRC | Shigellosis | 59/1091 | 247/8465 | 1.19e-06 | 5.41e-05 | 3.66e-05 | 59 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBX3 | SNV | Missense_Mutation | c.420N>A | p.Met140Ile | p.M140I | Q13185 | protein_coding | tolerated(0.35) | benign(0.015) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
CBX3 | SNV | Missense_Mutation | c.185A>C | p.Glu62Ala | p.E62A | Q13185 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CBX3 | SNV | Missense_Mutation | c.458C>T | p.Ala153Val | p.A153V | Q13185 | protein_coding | deleterious(0) | possibly_damaging(0.606) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CBX3 | SNV | Missense_Mutation | c.153G>C | p.Trp51Cys | p.W51C | Q13185 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
CBX3 | deletion | Frame_Shift_Del | c.36delN | p.Lys14AsnfsTer23 | p.K14Nfs*23 | Q13185 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CBX3 | deletion | Frame_Shift_Del | c.26delN | p.Met11TrpfsTer26 | p.M11Wfs*26 | Q13185 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
CBX3 | deletion | Frame_Shift_Del | c.31delA | p.Met11TrpfsTer26 | p.M11Wfs*26 | Q13185 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |||
CBX3 | deletion | Frame_Shift_Del | c.26delN | p.Met11TrpfsTer26 | p.M11Wfs*26 | Q13185 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CBX3 | SNV | Missense_Mutation | novel | c.477G>T | p.Lys159Asn | p.K159N | Q13185 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CBX3 | SNV | Missense_Mutation | novel | c.4G>A | p.Ala2Thr | p.A2T | Q13185 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.483) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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