Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAMKK2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAMKK2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAMKK2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAMKK2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:190300816 | Esophagus | ESCC | organelle disassembly | 89/8552 | 114/18723 | 1.36e-12 | 5.80e-11 | 89 |
GO:0010821110 | Esophagus | ESCC | regulation of mitochondrion organization | 107/8552 | 144/18723 | 2.31e-12 | 9.41e-11 | 107 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:000042217 | Esophagus | ESCC | autophagy of mitochondrion | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:006172617 | Esophagus | ESCC | mitochondrion disassembly | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:001082215 | Esophagus | ESCC | positive regulation of mitochondrion organization | 58/8552 | 74/18723 | 8.55e-09 | 1.73e-07 | 58 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:001050816 | Esophagus | ESCC | positive regulation of autophagy | 81/8552 | 124/18723 | 7.74e-06 | 7.65e-05 | 81 |
GO:190314610 | Esophagus | ESCC | regulation of autophagy of mitochondrion | 27/8552 | 33/18723 | 2.20e-05 | 1.89e-04 | 27 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:19035999 | Esophagus | ESCC | positive regulation of autophagy of mitochondrion | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMKK2 | SNV | Missense_Mutation | | c.854N>T | p.Ser285Phe | p.S285F | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAMKK2 | SNV | Missense_Mutation | rs200801054 | c.289N>T | p.Arg97Cys | p.R97C | Q96RR4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.889) | TCGA-BH-A18I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CAMKK2 | SNV | Missense_Mutation | | c.859N>A | p.Asp287Asn | p.D287N | Q96RR4 | protein_coding | tolerated(0.1) | benign(0.374) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CAMKK2 | SNV | Missense_Mutation | | c.17N>G | p.Ser6Cys | p.S6C | Q96RR4 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.533) | TCGA-FU-A5XV-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.55N>A | p.Glu19Lys | p.E19K | Q96RR4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.022) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAMKK2 | SNV | Missense_Mutation | | c.1520N>G | p.Glu507Gly | p.E507G | Q96RR4 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAMKK2 | SNV | Missense_Mutation | novel | c.1371N>T | p.Glu457Asp | p.E457D | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.1474N>T | p.Arg492Cys | p.R492C | Q96RR4 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.802N>A | p.Glu268Lys | p.E268K | Q96RR4 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMKK2 | SNV | Missense_Mutation | | c.1746G>T | p.Glu582Asp | p.E582D | Q96RR4 | protein_coding | tolerated_low_confidence(0.58) | benign(0) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | PF-562271 | PF-00562271 | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | inhibitor | 178101957 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | US9623028, Compound 101 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | CQ7 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | JNJ-7706621 | JNJ-7706621 | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | DOVITINIB | DOVITINIB | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | US9623028, Compound 79 | | |
10645 | CAMKK2 | KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE, SERINE THREONINE KINASE | | AST-487 | AST-487 | |