Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CACFD1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CACFD1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CACFD1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CACFD1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CACFD1 | SNV | Missense_Mutation | | c.426N>T | p.Lys142Asn | p.K142N | Q9UGQ2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
CACFD1 | SNV | Missense_Mutation | | c.350N>C | p.Leu117Pro | p.L117P | Q9UGQ2 | protein_coding | tolerated(0.2) | probably_damaging(0.967) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CACFD1 | SNV | Missense_Mutation | rs867108595 | c.655G>A | p.Ala219Thr | p.A219T | Q9UGQ2 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CACFD1 | SNV | Missense_Mutation | novel | c.646G>T | p.Gly216Trp | p.G216W | Q9UGQ2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.792) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CACFD1 | SNV | Missense_Mutation | rs782205792 | c.382N>A | p.Ala128Thr | p.A128T | Q9UGQ2 | protein_coding | tolerated(0.21) | benign(0.184) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CACFD1 | SNV | Missense_Mutation | rs782073285 | c.563N>A | p.Arg188Gln | p.R188Q | Q9UGQ2 | protein_coding | tolerated_low_confidence(0.39) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CACFD1 | SNV | Missense_Mutation | rs782205792 | c.382N>A | p.Ala128Thr | p.A128T | Q9UGQ2 | protein_coding | tolerated(0.21) | benign(0.184) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CACFD1 | SNV | Missense_Mutation | | c.127N>A | p.Ala43Thr | p.A43T | Q9UGQ2 | protein_coding | deleterious(0.05) | benign(0.104) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CACFD1 | SNV | Missense_Mutation | novel | c.435N>T | p.Gln145His | p.Q145H | Q9UGQ2 | protein_coding | deleterious(0.02) | possibly_damaging(0.607) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CACFD1 | SNV | Missense_Mutation | | c.218N>C | p.Leu73Pro | p.L73P | Q9UGQ2 | protein_coding | deleterious(0.01) | probably_damaging(0.955) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |