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Gene: C7orf73 |
Gene summary for C7ORF73 |
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Gene information | Species | Human | Gene symbol | C7orf73 | Gene ID | 647087 |
Gene name | short transmembrane mitochondrial protein 1 | |
Gene Alias | C7orf73 | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | E0CX11 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
647087 | C7orf73 | P127T-E | Human | Esophagus | ESCC | 4.92e-27 | 4.14e-01 | 0.0826 |
647087 | C7orf73 | P128T-E | Human | Esophagus | ESCC | 6.01e-45 | 1.72e+00 | 0.1241 |
647087 | C7orf73 | P130T-E | Human | Esophagus | ESCC | 2.76e-87 | 1.96e+00 | 0.1676 |
647087 | C7orf73 | S43 | Human | Liver | Cirrhotic | 6.97e-20 | -4.11e-01 | -0.0187 |
647087 | C7orf73 | HCC1_Meng | Human | Liver | HCC | 8.85e-83 | 3.23e-01 | 0.0246 |
647087 | C7orf73 | HCC2_Meng | Human | Liver | HCC | 6.38e-42 | 4.03e-02 | 0.0107 |
647087 | C7orf73 | cirrhotic1 | Human | Liver | Cirrhotic | 3.48e-19 | 1.91e-01 | 0.0202 |
647087 | C7orf73 | cirrhotic2 | Human | Liver | Cirrhotic | 1.32e-21 | 2.92e-01 | 0.0201 |
647087 | C7orf73 | cirrhotic3 | Human | Liver | Cirrhotic | 1.57e-22 | 2.98e-01 | 0.0215 |
647087 | C7orf73 | HCC1 | Human | Liver | HCC | 1.46e-03 | 2.88e+00 | 0.5336 |
647087 | C7orf73 | HCC2 | Human | Liver | HCC | 2.11e-14 | 3.47e+00 | 0.5341 |
647087 | C7orf73 | Pt13.a | Human | Liver | HCC | 1.68e-04 | 1.07e-01 | 0.021 |
647087 | C7orf73 | Pt13.b | Human | Liver | HCC | 4.90e-31 | 1.74e-01 | 0.0251 |
647087 | C7orf73 | Pt14.a | Human | Liver | HCC | 2.76e-15 | 4.73e-01 | 0.0169 |
647087 | C7orf73 | Pt14.b | Human | Liver | HCC | 1.91e-11 | 3.68e-01 | 0.018 |
647087 | C7orf73 | S014 | Human | Liver | HCC | 5.14e-07 | -4.11e-01 | 0.2254 |
647087 | C7orf73 | S015 | Human | Liver | HCC | 2.11e-04 | -4.11e-01 | 0.2375 |
647087 | C7orf73 | S016 | Human | Liver | HCC | 3.06e-09 | -4.11e-01 | 0.2243 |
647087 | C7orf73 | S028 | Human | Liver | HCC | 3.69e-05 | -4.11e-01 | 0.2503 |
647087 | C7orf73 | S029 | Human | Liver | HCC | 3.30e-04 | -4.11e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf73 | SNV | Missense_Mutation | novel | c.60G>T | p.Gln20His | p.Q20H | E0CX11 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.977) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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