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Gene: C4orf48 |
Gene summary for C4ORF48 |
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Gene information | Species | Human | Gene symbol | C4orf48 | Gene ID | 401115 |
Gene name | chromosome 4 open reading frame 48 | |
Gene Alias | CHR4_55 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401115 | C4orf48 | P31T-E | Human | Esophagus | ESCC | 3.73e-44 | 9.61e-01 | 0.1251 |
401115 | C4orf48 | P32T-E | Human | Esophagus | ESCC | 2.34e-57 | 1.25e+00 | 0.1666 |
401115 | C4orf48 | P36T-E | Human | Esophagus | ESCC | 1.37e-19 | 8.55e-01 | 0.1187 |
401115 | C4orf48 | P37T-E | Human | Esophagus | ESCC | 2.72e-30 | 7.71e-01 | 0.1371 |
401115 | C4orf48 | P38T-E | Human | Esophagus | ESCC | 1.29e-20 | 9.94e-01 | 0.127 |
401115 | C4orf48 | P39T-E | Human | Esophagus | ESCC | 3.00e-15 | 4.26e-01 | 0.0894 |
401115 | C4orf48 | P40T-E | Human | Esophagus | ESCC | 1.89e-16 | 7.74e-01 | 0.109 |
401115 | C4orf48 | P42T-E | Human | Esophagus | ESCC | 3.33e-14 | 5.91e-01 | 0.1175 |
401115 | C4orf48 | P44T-E | Human | Esophagus | ESCC | 3.51e-19 | 7.91e-01 | 0.1096 |
401115 | C4orf48 | P47T-E | Human | Esophagus | ESCC | 4.28e-30 | 7.07e-01 | 0.1067 |
401115 | C4orf48 | P48T-E | Human | Esophagus | ESCC | 9.44e-05 | 2.39e-01 | 0.0959 |
401115 | C4orf48 | P49T-E | Human | Esophagus | ESCC | 7.03e-10 | 9.50e-01 | 0.1768 |
401115 | C4orf48 | P52T-E | Human | Esophagus | ESCC | 1.09e-63 | 1.23e+00 | 0.1555 |
401115 | C4orf48 | P56T-E | Human | Esophagus | ESCC | 1.46e-11 | 1.76e+00 | 0.1613 |
401115 | C4orf48 | P57T-E | Human | Esophagus | ESCC | 1.97e-13 | 3.72e-01 | 0.0926 |
401115 | C4orf48 | P61T-E | Human | Esophagus | ESCC | 5.27e-34 | 8.86e-01 | 0.099 |
401115 | C4orf48 | P62T-E | Human | Esophagus | ESCC | 2.12e-25 | 8.22e-01 | 0.1302 |
401115 | C4orf48 | P65T-E | Human | Esophagus | ESCC | 2.99e-06 | 1.94e-01 | 0.0978 |
401115 | C4orf48 | P74T-E | Human | Esophagus | ESCC | 1.15e-28 | 8.60e-01 | 0.1479 |
401115 | C4orf48 | P75T-E | Human | Esophagus | ESCC | 3.26e-39 | 1.02e+00 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C4orf48 | deletion | Frame_Shift_Del | novel | c.351delN | p.Arg118ValfsTer20 | p.R118Vfs*20 | Q5BLP8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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