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Gene: C4orf19 |
Gene summary for C4ORF19 |
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Gene information | Species | Human | Gene symbol | C4orf19 | Gene ID | 55286 |
Gene name | chromosome 4 open reading frame 19 | |
Gene Alias | C4orf19 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R9R1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55286 | C4orf19 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 9.73e-04 | 8.86e-01 | -0.1271 |
55286 | C4orf19 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 4.78e-03 | 7.17e-01 | -0.1406 |
55286 | C4orf19 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.96e-04 | 9.42e-01 | -0.1408 |
55286 | C4orf19 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 3.40e-03 | 8.28e-01 | -0.138 |
55286 | C4orf19 | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 1.88e-02 | 7.54e-01 | -0.037 |
55286 | C4orf19 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 2.66e-03 | 9.60e-01 | -0.028 |
55286 | C4orf19 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 9.64e-15 | 6.43e-01 | -0.2116 |
55286 | C4orf19 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.76e-04 | 6.75e-01 | -0.1941 |
55286 | C4orf19 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.42e-04 | 5.40e-01 | -0.2107 |
55286 | C4orf19 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.85e-06 | 5.83e-01 | -0.2119 |
55286 | C4orf19 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 3.45e-02 | 6.77e-01 | -0.0186 |
55286 | C4orf19 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.05e-02 | 5.83e-01 | -0.0263 |
55286 | C4orf19 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.82e-11 | 5.50e-01 | -0.0166 |
55286 | C4orf19 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.89e-19 | 6.62e-01 | -0.0132 |
55286 | C4orf19 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.69e-16 | 5.37e-01 | -0.013 |
55286 | C4orf19 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 9.21e-13 | 5.36e-01 | -0.0121 |
55286 | C4orf19 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.21e-05 | 6.95e-01 | -0.0961 |
55286 | C4orf19 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 6.82e-07 | 7.00e-01 | -0.0876 |
55286 | C4orf19 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.59e-08 | 7.69e-01 | -0.0822 |
55286 | C4orf19 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.53e-10 | 7.40e-01 | -0.0809 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf19 | SNV | Missense_Mutation | c.103G>A | p.Glu35Lys | p.E35K | Q8IY42 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
C4orf19 | SNV | Missense_Mutation | c.470N>A | p.Val157Asp | p.V157D | Q8IY42 | protein_coding | deleterious(0.04) | benign(0.067) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
C4orf19 | SNV | Missense_Mutation | rs768318711 | c.687G>C | p.Leu229Phe | p.L229F | Q8IY42 | protein_coding | deleterious(0.02) | possibly_damaging(0.66) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C4orf19 | SNV | Missense_Mutation | novel | c.538G>T | p.Val180Phe | p.V180F | Q8IY42 | protein_coding | tolerated(0.11) | possibly_damaging(0.79) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C4orf19 | deletion | Frame_Shift_Del | c.391delN | p.Pro132GlnfsTer27 | p.P132Qfs*27 | Q8IY42 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
C4orf19 | SNV | Missense_Mutation | novel | c.266C>A | p.Ala89Asp | p.A89D | Q8IY42 | protein_coding | tolerated(0.54) | benign(0.019) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C4orf19 | SNV | Missense_Mutation | novel | c.701N>A | p.Ser234Tyr | p.S234Y | Q8IY42 | protein_coding | deleterious(0.01) | possibly_damaging(0.838) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4orf19 | SNV | Missense_Mutation | novel | c.43N>T | p.Asp15Tyr | p.D15Y | Q8IY42 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C4orf19 | SNV | Missense_Mutation | rs777330778 | c.884N>T | p.Ala295Val | p.A295V | Q8IY42 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4orf19 | SNV | Missense_Mutation | rs768230851 | c.785N>G | p.His262Arg | p.H262R | Q8IY42 | protein_coding | tolerated(0.64) | benign(0.005) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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