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Gene: C1orf35 |
Gene summary for C1ORF35 |
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Gene information | Species | Human | Gene symbol | C1orf35 | Gene ID | 79169 |
Gene name | chromosome 1 open reading frame 35 | |
Gene Alias | MMTAG2 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BU76 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79169 | C1orf35 | S028 | Human | Liver | HCC | 1.44e-32 | 1.54e+00 | 0.2503 |
79169 | C1orf35 | S029 | Human | Liver | HCC | 1.01e-30 | 1.66e+00 | 0.2581 |
79169 | C1orf35 | C04 | Human | Oral cavity | OSCC | 3.40e-27 | 1.68e+00 | 0.2633 |
79169 | C1orf35 | C21 | Human | Oral cavity | OSCC | 1.25e-48 | 1.76e+00 | 0.2678 |
79169 | C1orf35 | C30 | Human | Oral cavity | OSCC | 2.69e-24 | 1.38e+00 | 0.3055 |
79169 | C1orf35 | C38 | Human | Oral cavity | OSCC | 1.97e-08 | 1.22e+00 | 0.172 |
79169 | C1orf35 | C43 | Human | Oral cavity | OSCC | 6.67e-27 | 5.83e-01 | 0.1704 |
79169 | C1orf35 | C46 | Human | Oral cavity | OSCC | 1.52e-21 | 7.40e-01 | 0.1673 |
79169 | C1orf35 | C51 | Human | Oral cavity | OSCC | 2.37e-15 | 1.04e+00 | 0.2674 |
79169 | C1orf35 | C57 | Human | Oral cavity | OSCC | 1.27e-09 | 5.86e-01 | 0.1679 |
79169 | C1orf35 | C06 | Human | Oral cavity | OSCC | 9.47e-04 | 1.11e+00 | 0.2699 |
79169 | C1orf35 | C08 | Human | Oral cavity | OSCC | 3.65e-49 | 1.04e+00 | 0.1919 |
79169 | C1orf35 | C09 | Human | Oral cavity | OSCC | 2.73e-03 | 3.29e-01 | 0.1431 |
79169 | C1orf35 | LN22 | Human | Oral cavity | OSCC | 3.38e-05 | 9.56e-01 | 0.1733 |
79169 | C1orf35 | LN38 | Human | Oral cavity | OSCC | 2.14e-03 | 1.08e+00 | 0.168 |
79169 | C1orf35 | LN46 | Human | Oral cavity | OSCC | 2.75e-07 | 5.21e-01 | 0.1666 |
79169 | C1orf35 | LP15 | Human | Oral cavity | LP | 1.89e-04 | 1.15e+00 | 0.2174 |
79169 | C1orf35 | LP17 | Human | Oral cavity | LP | 1.77e-03 | 8.61e-01 | 0.2349 |
79169 | C1orf35 | SYSMH1 | Human | Oral cavity | OSCC | 3.69e-11 | 4.22e-01 | 0.1127 |
79169 | C1orf35 | SYSMH2 | Human | Oral cavity | OSCC | 1.97e-23 | 8.76e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf35 | SNV | Missense_Mutation | c.280N>A | p.Leu94Met | p.L94M | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
C1orf35 | SNV | Missense_Mutation | novel | c.264N>T | p.Lys88Asn | p.K88N | Q9BU76 | protein_coding | tolerated(0.06) | benign(0.146) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.550N>G | p.Lys184Glu | p.K184E | Q9BU76 | protein_coding | tolerated(0.28) | probably_damaging(0.968) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs748613886 | c.658T>C | p.Ser220Pro | p.S220P | Q9BU76 | protein_coding | tolerated(0.11) | benign(0.202) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs534724964 | c.629N>A | p.Arg210Gln | p.R210Q | Q9BU76 | protein_coding | tolerated(0.07) | benign(0) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs140393278 | c.761N>A | p.Arg254His | p.R254H | Q9BU76 | protein_coding | tolerated_low_confidence(0.48) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.470G>A | p.Gly157Glu | p.G157E | Q9BU76 | protein_coding | tolerated(0.97) | benign(0.08) | TCGA-UB-AA0U-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
C1orf35 | SNV | Missense_Mutation | c.437N>G | p.Ser146Cys | p.S146C | Q9BU76 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-69-7760-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C1orf35 | SNV | Missense_Mutation | novel | c.80N>T | p.Arg27Leu | p.R27L | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-91-6835-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.28N>G | p.Arg10Gly | p.R10G | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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