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Gene: C19orf43 |
Gene summary for C19ORF43 |
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Gene information | Species | Human | Gene symbol | C19orf43 | Gene ID | 79002 |
Gene name | telomerase RNA component interacting RNase | |
Gene Alias | C19orf43 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7EN60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79002 | C19orf43 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 6.48e-85 | -9.34e-01 | -0.1269 |
79002 | C19orf43 | LZE24T | Human | Esophagus | ESCC | 2.55e-02 | -2.90e-01 | 0.0596 |
79002 | C19orf43 | P1T-E | Human | Esophagus | ESCC | 9.56e-39 | 2.07e+00 | 0.0875 |
79002 | C19orf43 | P2T-E | Human | Esophagus | ESCC | 2.48e-78 | 1.45e+00 | 0.1177 |
79002 | C19orf43 | P4T-E | Human | Esophagus | ESCC | 7.96e-98 | 2.22e+00 | 0.1323 |
79002 | C19orf43 | P5T-E | Human | Esophagus | ESCC | 1.82e-112 | 2.12e+00 | 0.1327 |
79002 | C19orf43 | P8T-E | Human | Esophagus | ESCC | 3.05e-99 | 2.04e+00 | 0.0889 |
79002 | C19orf43 | P9T-E | Human | Esophagus | ESCC | 4.46e-79 | 2.04e+00 | 0.1131 |
79002 | C19orf43 | P10T-E | Human | Esophagus | ESCC | 6.75e-97 | 1.72e+00 | 0.116 |
79002 | C19orf43 | P11T-E | Human | Esophagus | ESCC | 4.84e-41 | 1.94e+00 | 0.1426 |
79002 | C19orf43 | P12T-E | Human | Esophagus | ESCC | 1.43e-109 | 1.94e+00 | 0.1122 |
79002 | C19orf43 | P15T-E | Human | Esophagus | ESCC | 1.95e-68 | 1.51e+00 | 0.1149 |
79002 | C19orf43 | P16T-E | Human | Esophagus | ESCC | 8.00e-59 | 1.15e+00 | 0.1153 |
79002 | C19orf43 | P17T-E | Human | Esophagus | ESCC | 5.34e-41 | 1.87e+00 | 0.1278 |
79002 | C19orf43 | P19T-E | Human | Esophagus | ESCC | 3.20e-24 | 2.20e+00 | 0.1662 |
79002 | C19orf43 | P20T-E | Human | Esophagus | ESCC | 3.89e-74 | 1.76e+00 | 0.1124 |
79002 | C19orf43 | P21T-E | Human | Esophagus | ESCC | 2.22e-119 | 2.39e+00 | 0.1617 |
79002 | C19orf43 | P22T-E | Human | Esophagus | ESCC | 8.40e-121 | 2.13e+00 | 0.1236 |
79002 | C19orf43 | P23T-E | Human | Esophagus | ESCC | 4.57e-98 | 2.87e+00 | 0.108 |
79002 | C19orf43 | P24T-E | Human | Esophagus | ESCC | 3.69e-102 | 1.94e+00 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf43 | SNV | Missense_Mutation | c.442G>A | p.Asp148Asn | p.D148N | Q9BQ61 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C19orf43 | SNV | Missense_Mutation | c.466N>A | p.Glu156Lys | p.E156K | Q9BQ61 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
C19orf43 | SNV | Missense_Mutation | c.362G>A | p.Gly121Asp | p.G121D | Q9BQ61 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
C19orf43 | SNV | Missense_Mutation | c.463N>A | p.Ala155Thr | p.A155T | Q9BQ61 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C19orf43 | SNV | Missense_Mutation | novel | c.445G>A | p.Ala149Thr | p.A149T | Q9BQ61 | protein_coding | deleterious(0.01) | benign(0.096) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
C19orf43 | SNV | Missense_Mutation | c.505G>A | p.Asp169Asn | p.D169N | Q9BQ61 | protein_coding | tolerated(0.1) | possibly_damaging(0.58) | TCGA-AP-A0LF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
C19orf43 | SNV | Missense_Mutation | novel | c.397G>A | p.Ala133Thr | p.A133T | Q9BQ61 | protein_coding | deleterious(0.04) | benign(0.319) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf43 | SNV | Missense_Mutation | novel | c.474A>C | p.Lys158Asn | p.K158N | Q9BQ61 | protein_coding | tolerated(0.11) | possibly_damaging(0.662) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf43 | SNV | Missense_Mutation | c.505N>A | p.Asp169Asn | p.D169N | Q9BQ61 | protein_coding | tolerated(0.1) | possibly_damaging(0.58) | TCGA-E6-A1LZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C19orf43 | SNV | Missense_Mutation | novel | c.436A>G | p.Lys146Glu | p.K146E | Q9BQ61 | protein_coding | tolerated(0.13) | probably_damaging(0.994) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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