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Gene: C11orf80 |
Gene summary for C11ORF80 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C11orf80 | Gene ID | 79703 |
Gene name | chromosome 11 open reading frame 80 | |
Gene Alias | HYDM4 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DXL1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79703 | C11orf80 | C46 | Human | Oral cavity | OSCC | 4.22e-22 | 4.34e-01 | 0.1673 |
79703 | C11orf80 | C51 | Human | Oral cavity | OSCC | 2.23e-13 | 6.15e-01 | 0.2674 |
79703 | C11orf80 | C06 | Human | Oral cavity | OSCC | 2.79e-02 | 4.12e-01 | 0.2699 |
79703 | C11orf80 | C08 | Human | Oral cavity | OSCC | 2.12e-17 | 4.24e-01 | 0.1919 |
79703 | C11orf80 | LN46 | Human | Oral cavity | OSCC | 1.09e-05 | 2.41e-01 | 0.1666 |
79703 | C11orf80 | EOLP-1 | Human | Oral cavity | EOLP | 6.73e-04 | 1.85e-01 | -0.0202 |
79703 | C11orf80 | SYSMH1 | Human | Oral cavity | OSCC | 6.89e-14 | 3.06e-01 | 0.1127 |
79703 | C11orf80 | SYSMH2 | Human | Oral cavity | OSCC | 7.34e-11 | 3.58e-01 | 0.2326 |
79703 | C11orf80 | SYSMH3 | Human | Oral cavity | OSCC | 5.41e-04 | 1.39e-01 | 0.2442 |
79703 | C11orf80 | SYSMH5 | Human | Oral cavity | OSCC | 8.11e-04 | 8.69e-02 | 0.0647 |
79703 | C11orf80 | SYSMH6 | Human | Oral cavity | OSCC | 8.91e-05 | 8.73e-02 | 0.1275 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:00002801 | Oral cavity | OSCC | nuclear division | 237/7305 | 439/18723 | 9.62e-11 | 2.90e-09 | 237 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C11orf80 | SNV | Missense_Mutation | novel | c.1649N>T | p.Cys550Phe | p.C550F | Q8N6T0 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
C11orf80 | insertion | Frame_Shift_Ins | novel | c.807_808insA | p.Gly270ArgfsTer20 | p.G270Rfs*20 | Q8N6T0 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
C11orf80 | insertion | Frame_Shift_Ins | novel | c.809_810insACAAT | p.Ile271GlnfsTer2 | p.I271Qfs*2 | Q8N6T0 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
C11orf80 | insertion | Frame_Shift_Ins | rs779402951 | c.783dupT | p.Glu262Ter | p.E262* | Q8N6T0 | protein_coding | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
C11orf80 | deletion | Frame_Shift_Del | c.1191delN | p.Leu398TrpfsTer6 | p.L398Wfs*6 | Q8N6T0 | protein_coding | TCGA-E2-A15A-06 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |||
C11orf80 | SNV | Missense_Mutation | rs763038216 | c.502N>A | p.Val168Ile | p.V168I | Q8N6T0 | protein_coding | tolerated(0.14) | benign(0.16) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C11orf80 | SNV | Missense_Mutation | c.1681N>C | p.Glu561Gln | p.E561Q | Q8N6T0 | protein_coding | deleterious(0.04) | possibly_damaging(0.615) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
C11orf80 | SNV | Missense_Mutation | novel | c.185N>C | p.Arg62Thr | p.R62T | Q8N6T0 | protein_coding | deleterious(0.01) | possibly_damaging(0.848) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
C11orf80 | SNV | Missense_Mutation | c.2005G>A | p.Glu669Lys | p.E669K | Q8N6T0 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C11orf80 | SNV | Missense_Mutation | c.671T>A | p.Leu224Gln | p.L224Q | Q8N6T0 | protein_coding | tolerated(0.06) | probably_damaging(0.945) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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