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Gene: BRD2 |
Gene summary for BRD2 |
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Gene information | Species | Human | Gene symbol | BRD2 | Gene ID | 6046 |
Gene name | bromodomain containing 2 | |
Gene Alias | BRD2-IT1 | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RCR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6046 | BRD2 | P15T-E | Human | Esophagus | ESCC | 6.43e-44 | 1.67e+00 | 0.1149 |
6046 | BRD2 | P16T-E | Human | Esophagus | ESCC | 3.08e-46 | 1.38e+00 | 0.1153 |
6046 | BRD2 | P17T-E | Human | Esophagus | ESCC | 2.94e-08 | 1.19e+00 | 0.1278 |
6046 | BRD2 | P19T-E | Human | Esophagus | ESCC | 2.31e-04 | 1.08e+00 | 0.1662 |
6046 | BRD2 | P20T-E | Human | Esophagus | ESCC | 1.59e-32 | 1.56e+00 | 0.1124 |
6046 | BRD2 | P21T-E | Human | Esophagus | ESCC | 2.69e-25 | 1.03e+00 | 0.1617 |
6046 | BRD2 | P22T-E | Human | Esophagus | ESCC | 4.61e-32 | 1.03e+00 | 0.1236 |
6046 | BRD2 | P23T-E | Human | Esophagus | ESCC | 4.68e-47 | 1.96e+00 | 0.108 |
6046 | BRD2 | P24T-E | Human | Esophagus | ESCC | 9.20e-13 | 9.30e-01 | 0.1287 |
6046 | BRD2 | P26T-E | Human | Esophagus | ESCC | 1.90e-42 | 1.32e+00 | 0.1276 |
6046 | BRD2 | P27T-E | Human | Esophagus | ESCC | 2.52e-59 | 2.13e+00 | 0.1055 |
6046 | BRD2 | P28T-E | Human | Esophagus | ESCC | 3.10e-68 | 2.29e+00 | 0.1149 |
6046 | BRD2 | P30T-E | Human | Esophagus | ESCC | 1.48e-41 | 2.60e+00 | 0.137 |
6046 | BRD2 | P31T-E | Human | Esophagus | ESCC | 4.65e-42 | 1.32e+00 | 0.1251 |
6046 | BRD2 | P32T-E | Human | Esophagus | ESCC | 8.13e-06 | 2.67e-01 | 0.1666 |
6046 | BRD2 | P36T-E | Human | Esophagus | ESCC | 3.18e-19 | 1.26e+00 | 0.1187 |
6046 | BRD2 | P37T-E | Human | Esophagus | ESCC | 8.75e-20 | 8.55e-01 | 0.1371 |
6046 | BRD2 | P38T-E | Human | Esophagus | ESCC | 3.41e-02 | 5.87e-01 | 0.127 |
6046 | BRD2 | P39T-E | Human | Esophagus | ESCC | 6.33e-25 | 1.04e+00 | 0.0894 |
6046 | BRD2 | P40T-E | Human | Esophagus | ESCC | 8.30e-16 | 1.20e+00 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00351486 | Breast | Precancer | tube formation | 19/1080 | 148/18723 | 8.79e-04 | 1.01e-02 | 19 |
GO:00018386 | Breast | Precancer | embryonic epithelial tube formation | 15/1080 | 121/18723 | 4.12e-03 | 3.24e-02 | 15 |
GO:00605625 | Breast | Precancer | epithelial tube morphogenesis | 31/1080 | 325/18723 | 4.21e-03 | 3.31e-02 | 31 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:003514812 | Breast | IDC | tube formation | 23/1434 | 148/18723 | 8.79e-04 | 1.02e-02 | 23 |
GO:000183812 | Breast | IDC | embryonic epithelial tube formation | 19/1434 | 121/18723 | 2.10e-03 | 1.97e-02 | 19 |
GO:00721756 | Breast | IDC | epithelial tube formation | 19/1434 | 132/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:006056221 | Breast | DCIS | epithelial tube morphogenesis | 41/1390 | 325/18723 | 5.98e-04 | 7.60e-03 | 41 |
GO:003514821 | Breast | DCIS | tube formation | 21/1390 | 148/18723 | 3.08e-03 | 2.62e-02 | 21 |
GO:000183821 | Breast | DCIS | embryonic epithelial tube formation | 18/1390 | 121/18723 | 3.54e-03 | 2.92e-02 | 18 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0014020 | Colorectum | AD | primary neural tube formation | 33/3918 | 94/18723 | 1.02e-03 | 9.50e-03 | 33 |
GO:0001841 | Colorectum | AD | neural tube formation | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0001843 | Colorectum | AD | neural tube closure | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0060606 | Colorectum | AD | tube closure | 30/3918 | 89/18723 | 3.42e-03 | 2.49e-02 | 30 |
GO:0035148 | Colorectum | AD | tube formation | 45/3918 | 148/18723 | 4.13e-03 | 2.87e-02 | 45 |
GO:0001838 | Colorectum | AD | embryonic epithelial tube formation | 38/3918 | 121/18723 | 4.40e-03 | 3.01e-02 | 38 |
GO:0072175 | Colorectum | AD | epithelial tube formation | 40/3918 | 132/18723 | 6.98e-03 | 4.29e-02 | 40 |
GO:0021915 | Colorectum | AD | neural tube development | 45/3918 | 152/18723 | 7.05e-03 | 4.31e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRD2 | SNV | Missense_Mutation | novel | c.2348N>G | p.Asn783Ser | p.N783S | P25440 | protein_coding | tolerated(0.08) | probably_damaging(0.97) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRD2 | insertion | Nonsense_Mutation | novel | c.2480_2481insCTGATAAAT | p.Ser827_Ser828insTer | p.S827_S828ins* | P25440 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
BRD2 | deletion | Frame_Shift_Del | novel | c.184_185delCC | p.Pro62ThrfsTer65 | p.P62Tfs*65 | P25440 | protein_coding | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | ||
BRD2 | SNV | Missense_Mutation | novel | c.1556G>A | p.Arg519His | p.R519H | P25440 | protein_coding | tolerated(0.06) | possibly_damaging(0.883) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BRD2 | SNV | Missense_Mutation | novel | c.101N>C | p.Arg34Pro | p.R34P | P25440 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
BRD2 | SNV | Missense_Mutation | c.596N>A | p.Gly199Glu | p.G199E | P25440 | protein_coding | tolerated(0.13) | benign(0.316) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
BRD2 | SNV | Missense_Mutation | novel | c.292N>T | p.Pro98Ser | p.P98S | P25440 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BRD2 | SNV | Missense_Mutation | novel | c.950G>A | p.Arg317His | p.R317H | P25440 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
BRD2 | SNV | Missense_Mutation | c.964N>T | p.Arg322Cys | p.R322C | P25440 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BRD2 | SNV | Missense_Mutation | c.1444N>G | p.Ser482Gly | p.S482G | P25440 | protein_coding | tolerated(0.32) | benign(0.017) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | TRIAZOLAM | TRIAZOLAM | 22137933 | |
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | Pyrrolo-pyrrolone derivative 1 | |||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 187051820 | ||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | PMID26924192-Compound-102 | |||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | PMID26924192-Compound-103 | |||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 187051816 | CHEMBL2153434 | |
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | OTX-015 | BIRABRESIB | ||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | ALPRAZOLAM | ALPRAZOLAM | 22137933 | |
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 187051823 | ||
6046 | BRD2 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 187051818 |
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