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Gene: BASP1 |
Gene summary for BASP1 |
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Gene information | Species | Human | Gene symbol | BASP1 | Gene ID | 10409 |
Gene name | brain abundant membrane attached signal protein 1 | |
Gene Alias | CAP-23 | |
Cytomap | 5p15.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P80723 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10409 | BASP1 | C07 | Human | Oral cavity | OSCC | 5.97e-03 | 1.74e+00 | 0.2491 |
10409 | BASP1 | C08 | Human | Oral cavity | OSCC | 3.18e-41 | 1.31e+00 | 0.1919 |
10409 | BASP1 | C09 | Human | Oral cavity | OSCC | 1.70e-37 | 1.43e+00 | 0.1431 |
10409 | BASP1 | LN46 | Human | Oral cavity | OSCC | 1.78e-15 | 9.48e-01 | 0.1666 |
10409 | BASP1 | LP15 | Human | Oral cavity | LP | 7.83e-05 | 1.43e+00 | 0.2174 |
10409 | BASP1 | SYSMH1 | Human | Oral cavity | OSCC | 8.38e-73 | 2.29e+00 | 0.1127 |
10409 | BASP1 | SYSMH2 | Human | Oral cavity | OSCC | 2.23e-31 | 1.56e+00 | 0.2326 |
10409 | BASP1 | SYSMH3 | Human | Oral cavity | OSCC | 2.25e-48 | 1.99e+00 | 0.2442 |
10409 | BASP1 | SYSMH4 | Human | Oral cavity | OSCC | 2.20e-11 | 5.12e-01 | 0.1226 |
10409 | BASP1 | SYSMH5 | Human | Oral cavity | OSCC | 2.65e-31 | 1.62e+00 | 0.0647 |
10409 | BASP1 | SYSMH6 | Human | Oral cavity | OSCC | 1.34e-06 | 1.17e+00 | 0.1275 |
10409 | BASP1 | P5_S10_cSCC | Human | Skin | cSCC | 9.71e-05 | 4.86e-02 | -0.299 |
10409 | BASP1 | P1_cSCC | Human | Skin | cSCC | 9.54e-30 | 1.63e+00 | 0.0292 |
10409 | BASP1 | P2_cSCC | Human | Skin | cSCC | 2.89e-02 | 2.95e-01 | -0.024 |
10409 | BASP1 | P10_cSCC | Human | Skin | cSCC | 8.09e-33 | 1.10e+00 | 0.1017 |
10409 | BASP1 | cSCC_p8 | Human | Skin | cSCC | 7.93e-04 | -1.05e-02 | -0.1971 |
10409 | BASP1 | cSCC_p9 | Human | Skin | cSCC | 1.11e-06 | -4.89e-03 | -0.1991 |
10409 | BASP1 | male-WTA | Human | Thyroid | PTC | 1.53e-67 | 8.33e-01 | 0.1037 |
10409 | BASP1 | PTC01 | Human | Thyroid | PTC | 1.11e-26 | 6.65e-01 | 0.1899 |
10409 | BASP1 | PTC04 | Human | Thyroid | PTC | 3.56e-03 | 3.36e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002176214 | Breast | IDC | substantia nigra development | 18/1434 | 44/18723 | 1.11e-09 | 1.07e-07 | 18 |
GO:004885713 | Breast | IDC | neural nucleus development | 21/1434 | 64/18723 | 5.35e-09 | 4.28e-07 | 21 |
GO:003090112 | Breast | IDC | midbrain development | 24/1434 | 90/18723 | 4.35e-08 | 2.87e-06 | 24 |
GO:004860812 | Breast | IDC | reproductive structure development | 60/1434 | 424/18723 | 2.71e-06 | 1.03e-04 | 60 |
GO:006145813 | Breast | IDC | reproductive system development | 60/1434 | 427/18723 | 3.41e-06 | 1.24e-04 | 60 |
GO:0008406 | Breast | IDC | gonad development | 32/1434 | 221/18723 | 3.64e-04 | 5.23e-03 | 32 |
GO:00605412 | Breast | IDC | respiratory system development | 30/1434 | 203/18723 | 3.85e-04 | 5.40e-03 | 30 |
GO:0045137 | Breast | IDC | development of primary sexual characteristics | 32/1434 | 227/18723 | 5.85e-04 | 7.44e-03 | 32 |
GO:0001656 | Breast | IDC | metanephros development | 16/1434 | 85/18723 | 6.49e-04 | 8.04e-03 | 16 |
GO:0090183 | Breast | IDC | regulation of kidney development | 8/1434 | 31/18723 | 1.86e-03 | 1.79e-02 | 8 |
GO:0007548 | Breast | IDC | sex differentiation | 35/1434 | 276/18723 | 2.23e-03 | 2.07e-02 | 35 |
GO:007207312 | Breast | IDC | kidney epithelium development | 20/1434 | 136/18723 | 3.58e-03 | 2.94e-02 | 20 |
GO:00016571 | Breast | IDC | ureteric bud development | 15/1434 | 91/18723 | 3.70e-03 | 3.04e-02 | 15 |
GO:00721631 | Breast | IDC | mesonephric epithelium development | 15/1434 | 92/18723 | 4.12e-03 | 3.26e-02 | 15 |
GO:00721641 | Breast | IDC | mesonephric tubule development | 15/1434 | 92/18723 | 4.12e-03 | 3.26e-02 | 15 |
GO:0060993 | Breast | IDC | kidney morphogenesis | 15/1434 | 93/18723 | 4.57e-03 | 3.52e-02 | 15 |
GO:00018231 | Breast | IDC | mesonephros development | 15/1434 | 96/18723 | 6.17e-03 | 4.40e-02 | 15 |
GO:00075172 | Breast | IDC | muscle organ development | 38/1434 | 327/18723 | 6.63e-03 | 4.62e-02 | 38 |
GO:00016555 | Breast | IDC | urogenital system development | 39/1434 | 338/18723 | 6.75e-03 | 4.68e-02 | 39 |
GO:0021762 | Colorectum | AD | substantia nigra development | 21/3918 | 44/18723 | 6.60e-05 | 1.07e-03 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BASP1 | SNV | Missense_Mutation | c.131N>A | p.Ala44Glu | p.A44E | P80723 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-WT-AB44-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
BASP1 | SNV | Missense_Mutation | novel | c.626C>A | p.Pro209His | p.P209H | P80723 | protein_coding | deleterious(0.03) | benign(0.382) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BASP1 | SNV | Missense_Mutation | c.110C>T | p.Pro37Leu | p.P37L | P80723 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | c.380C>T | p.Ala127Val | p.A127V | P80723 | protein_coding | tolerated(0.15) | benign(0.015) | TCGA-CM-6675-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD | |
BASP1 | SNV | Missense_Mutation | c.215N>T | p.Glu72Val | p.E72V | P80723 | protein_coding | tolerated(0.13) | benign(0.026) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | c.86N>T | p.Ala29Val | p.A29V | P80723 | protein_coding | deleterious(0.01) | possibly_damaging(0.494) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | rs767831759 | c.184G>A | p.Ala62Thr | p.A62T | P80723 | protein_coding | tolerated(0.05) | benign(0.013) | TCGA-DC-4745-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
BASP1 | SNV | Missense_Mutation | novel | c.207G>T | p.Lys69Asn | p.K69N | P80723 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BASP1 | SNV | Missense_Mutation | c.11A>C | p.Lys4Thr | p.K4T | P80723 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BASP1 | SNV | Missense_Mutation | novel | c.77N>T | p.Ala26Val | p.A26V | P80723 | protein_coding | tolerated(0.09) | possibly_damaging(0.575) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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