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Gene: ATP6AP2 |
Gene summary for ATP6AP2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ATP6AP2 | Gene ID | 10159 |
| Gene name | ATPase H+ transporting accessory protein 2 | |
| Gene Alias | APT6M8-9 | |
| Cytomap | Xp11.4 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O75787 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10159 | ATP6AP2 | P127T-E | Human | Esophagus | ESCC | 5.89e-24 | 5.04e-01 | 0.0826 |
| 10159 | ATP6AP2 | P128T-E | Human | Esophagus | ESCC | 2.32e-45 | 1.83e+00 | 0.1241 |
| 10159 | ATP6AP2 | P130T-E | Human | Esophagus | ESCC | 8.20e-73 | 1.91e+00 | 0.1676 |
| 10159 | ATP6AP2 | S43 | Human | Liver | Cirrhotic | 1.82e-05 | -2.12e-01 | -0.0187 |
| 10159 | ATP6AP2 | HCC1_Meng | Human | Liver | HCC | 3.07e-90 | 1.31e-01 | 0.0246 |
| 10159 | ATP6AP2 | HCC2_Meng | Human | Liver | HCC | 4.32e-46 | 1.80e-01 | 0.0107 |
| 10159 | ATP6AP2 | cirrhotic1 | Human | Liver | Cirrhotic | 5.32e-11 | -1.28e-02 | 0.0202 |
| 10159 | ATP6AP2 | cirrhotic2 | Human | Liver | Cirrhotic | 8.78e-29 | 3.86e-01 | 0.0201 |
| 10159 | ATP6AP2 | cirrhotic3 | Human | Liver | Cirrhotic | 2.54e-13 | -4.26e-03 | 0.0215 |
| 10159 | ATP6AP2 | HCC1 | Human | Liver | HCC | 3.13e-05 | 4.31e+00 | 0.5336 |
| 10159 | ATP6AP2 | HCC2 | Human | Liver | HCC | 1.17e-11 | 3.35e+00 | 0.5341 |
| 10159 | ATP6AP2 | HCC5 | Human | Liver | HCC | 6.22e-06 | 1.03e+00 | 0.4932 |
| 10159 | ATP6AP2 | Pt13.a | Human | Liver | HCC | 9.96e-03 | 7.55e-02 | 0.021 |
| 10159 | ATP6AP2 | Pt13.b | Human | Liver | HCC | 3.25e-30 | 2.06e-01 | 0.0251 |
| 10159 | ATP6AP2 | Pt14.a | Human | Liver | HCC | 9.34e-03 | -5.08e-02 | 0.0169 |
| 10159 | ATP6AP2 | Pt14.b | Human | Liver | HCC | 4.09e-05 | 6.44e-02 | 0.018 |
| 10159 | ATP6AP2 | S014 | Human | Liver | HCC | 2.78e-07 | 7.00e-01 | 0.2254 |
| 10159 | ATP6AP2 | S015 | Human | Liver | HCC | 1.64e-10 | 9.71e-01 | 0.2375 |
| 10159 | ATP6AP2 | S016 | Human | Liver | HCC | 2.17e-12 | 7.42e-01 | 0.2243 |
| 10159 | ATP6AP2 | S027 | Human | Liver | HCC | 4.89e-13 | 1.38e+00 | 0.2446 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
| GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
| GO:01987388 | Endometrium | AEH | cell-cell signaling by wnt | 85/2100 | 446/18723 | 6.07e-07 | 2.29e-05 | 85 |
| GO:00608288 | Endometrium | AEH | regulation of canonical Wnt signaling pathway | 54/2100 | 253/18723 | 2.22e-06 | 6.56e-05 | 54 |
| GO:00301777 | Endometrium | AEH | positive regulation of Wnt signaling pathway | 34/2100 | 140/18723 | 9.62e-06 | 2.23e-04 | 34 |
| GO:00600708 | Endometrium | AEH | canonical Wnt signaling pathway | 58/2100 | 303/18723 | 3.12e-05 | 5.66e-04 | 58 |
| GO:00902637 | Endometrium | AEH | positive regulation of canonical Wnt signaling pathway | 26/2100 | 106/18723 | 8.63e-05 | 1.27e-03 | 26 |
| GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
| GO:003011113 | Endometrium | EEC | regulation of Wnt signaling pathway | 74/2168 | 328/18723 | 1.03e-08 | 6.47e-07 | 74 |
| GO:001605513 | Endometrium | EEC | Wnt signaling pathway | 90/2168 | 444/18723 | 6.65e-08 | 3.50e-06 | 90 |
| GO:019873813 | Endometrium | EEC | cell-cell signaling by wnt | 90/2168 | 446/18723 | 8.25e-08 | 4.23e-06 | 90 |
| GO:006082813 | Endometrium | EEC | regulation of canonical Wnt signaling pathway | 56/2168 | 253/18723 | 1.18e-06 | 3.90e-05 | 56 |
| GO:006007013 | Endometrium | EEC | canonical Wnt signaling pathway | 61/2168 | 303/18723 | 1.05e-05 | 2.25e-04 | 61 |
| GO:003017713 | Endometrium | EEC | positive regulation of Wnt signaling pathway | 34/2168 | 140/18723 | 1.89e-05 | 3.50e-04 | 34 |
| GO:009026313 | Endometrium | EEC | positive regulation of canonical Wnt signaling pathway | 26/2168 | 106/18723 | 1.46e-04 | 1.87e-03 | 26 |
| GO:000181913 | Endometrium | EEC | positive regulation of cytokine production | 73/2168 | 467/18723 | 4.64e-03 | 2.97e-02 | 73 |
| GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
| GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
| GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
| GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ATP6AP2 | SNV | Missense_Mutation | rs745734335 | c.454N>T | p.Arg152Cys | p.R152C | O75787 | protein_coding | deleterious(0) | possibly_damaging(0.644) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ATP6AP2 | SNV | Missense_Mutation | c.515C>A | p.Ser172Tyr | p.S172Y | O75787 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATP6AP2 | SNV | Missense_Mutation | c.1017T>G | p.Ile339Met | p.I339M | O75787 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ATP6AP2 | SNV | Missense_Mutation | rs375148460 | c.262N>G | p.Leu88Val | p.L88V | O75787 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ATP6AP2 | SNV | Missense_Mutation | c.133N>A | p.Val45Met | p.V45M | O75787 | protein_coding | deleterious(0.02) | benign(0.054) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATP6AP2 | SNV | Missense_Mutation | c.152G>C | p.Gly51Ala | p.G51A | O75787 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ATP6AP2 | SNV | Missense_Mutation | novel | c.406A>G | p.Met136Val | p.M136V | O75787 | protein_coding | tolerated(0.36) | benign(0.046) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ATP6AP2 | SNV | Missense_Mutation | c.739N>C | p.Phe247Leu | p.F247L | O75787 | protein_coding | deleterious(0.03) | benign(0.028) | TCGA-NH-A50T-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATP6AP2 | SNV | Missense_Mutation | c.1043N>A | p.Arg348Gln | p.R348Q | O75787 | protein_coding | tolerated(0.05) | possibly_damaging(0.756) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ATP6AP2 | SNV | Missense_Mutation | novel | c.662N>T | p.Glu221Val | p.E221V | O75787 | protein_coding | tolerated(0.05) | benign(0.034) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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