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Gene: ATAD1 |
Gene summary for ATAD1 |
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Gene information | Species | Human | Gene symbol | ATAD1 | Gene ID | 84896 |
Gene name | ATPase family AAA domain containing 1 | |
Gene Alias | AFDC1 | |
Cytomap | 10q23.31 | |
Gene Type | protein-coding | GO ID | GO:0002090 | UniProtAcc | Q8NBU5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84896 | ATAD1 | P54T-E | Human | Esophagus | ESCC | 1.88e-27 | 5.12e-01 | 0.0975 |
84896 | ATAD1 | P56T-E | Human | Esophagus | ESCC | 7.19e-09 | 1.50e+00 | 0.1613 |
84896 | ATAD1 | P57T-E | Human | Esophagus | ESCC | 3.61e-16 | 2.65e-01 | 0.0926 |
84896 | ATAD1 | P61T-E | Human | Esophagus | ESCC | 2.91e-23 | 3.17e-01 | 0.099 |
84896 | ATAD1 | P62T-E | Human | Esophagus | ESCC | 3.27e-50 | 7.83e-01 | 0.1302 |
84896 | ATAD1 | P65T-E | Human | Esophagus | ESCC | 6.06e-23 | 2.07e-01 | 0.0978 |
84896 | ATAD1 | P74T-E | Human | Esophagus | ESCC | 5.71e-15 | 3.50e-01 | 0.1479 |
84896 | ATAD1 | P75T-E | Human | Esophagus | ESCC | 7.34e-36 | 5.05e-01 | 0.1125 |
84896 | ATAD1 | P76T-E | Human | Esophagus | ESCC | 3.72e-18 | 3.08e-01 | 0.1207 |
84896 | ATAD1 | P79T-E | Human | Esophagus | ESCC | 7.10e-28 | 4.42e-01 | 0.1154 |
84896 | ATAD1 | P80T-E | Human | Esophagus | ESCC | 2.27e-39 | 9.38e-01 | 0.155 |
84896 | ATAD1 | P82T-E | Human | Esophagus | ESCC | 2.46e-17 | 6.52e-01 | 0.1072 |
84896 | ATAD1 | P83T-E | Human | Esophagus | ESCC | 1.07e-38 | 9.38e-01 | 0.1738 |
84896 | ATAD1 | P84T-E | Human | Esophagus | ESCC | 4.57e-08 | 2.77e-01 | 0.0933 |
84896 | ATAD1 | P89T-E | Human | Esophagus | ESCC | 1.72e-15 | 8.42e-01 | 0.1752 |
84896 | ATAD1 | P91T-E | Human | Esophagus | ESCC | 2.83e-15 | 1.12e+00 | 0.1828 |
84896 | ATAD1 | P107T-E | Human | Esophagus | ESCC | 8.09e-32 | 7.73e-01 | 0.171 |
84896 | ATAD1 | P126T-E | Human | Esophagus | ESCC | 5.79e-06 | 4.52e-01 | 0.1125 |
84896 | ATAD1 | P127T-E | Human | Esophagus | ESCC | 2.84e-22 | 1.70e-01 | 0.0826 |
84896 | ATAD1 | P128T-E | Human | Esophagus | ESCC | 2.15e-27 | 6.49e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:0045807 | Colorectum | AD | positive regulation of endocytosis | 35/3918 | 100/18723 | 7.78e-04 | 7.78e-03 | 35 |
GO:0048260 | Colorectum | AD | positive regulation of receptor-mediated endocytosis | 20/3918 | 52/18723 | 2.87e-03 | 2.14e-02 | 20 |
GO:0048259 | Colorectum | AD | regulation of receptor-mediated endocytosis | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:0031623 | Colorectum | AD | receptor internalization | 35/3918 | 113/18723 | 7.72e-03 | 4.66e-02 | 35 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00301001 | Colorectum | SER | regulation of endocytosis | 48/2897 | 211/18723 | 3.29e-03 | 2.82e-02 | 48 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00431121 | Colorectum | MSS | receptor metabolic process | 57/3467 | 166/18723 | 8.47e-07 | 2.97e-05 | 57 |
GO:00301002 | Colorectum | MSS | regulation of endocytosis | 63/3467 | 211/18723 | 4.05e-05 | 7.66e-04 | 63 |
GO:00068981 | Colorectum | MSS | receptor-mediated endocytosis | 69/3467 | 244/18723 | 1.18e-04 | 1.82e-03 | 69 |
GO:00458071 | Colorectum | MSS | positive regulation of endocytosis | 33/3467 | 100/18723 | 3.73e-04 | 4.72e-03 | 33 |
GO:00482601 | Colorectum | MSS | positive regulation of receptor-mediated endocytosis | 19/3467 | 52/18723 | 1.66e-03 | 1.49e-02 | 19 |
GO:00482591 | Colorectum | MSS | regulation of receptor-mediated endocytosis | 33/3467 | 110/18723 | 2.33e-03 | 1.90e-02 | 33 |
GO:00316231 | Colorectum | MSS | receptor internalization | 32/3467 | 113/18723 | 7.02e-03 | 4.50e-02 | 32 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATAD1 | SNV | Missense_Mutation | novel | c.134G>A | p.Arg45Lys | p.R45K | Q8NBU5 | protein_coding | tolerated(0.37) | benign(0.027) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
ATAD1 | SNV | Missense_Mutation | c.238N>T | p.Leu80Phe | p.L80F | Q8NBU5 | protein_coding | tolerated(0.08) | possibly_damaging(0.533) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATAD1 | SNV | Missense_Mutation | novel | c.37N>T | p.Arg13Trp | p.R13W | Q8NBU5 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD |
ATAD1 | SNV | Missense_Mutation | novel | c.682N>G | p.Ser228Gly | p.S228G | Q8NBU5 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-AA-3972-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
ATAD1 | SNV | Missense_Mutation | rs780964486 | c.716N>A | p.Arg239His | p.R239H | Q8NBU5 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | c.188G>A | p.Gly63Glu | p.G63E | Q8NBU5 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATAD1 | SNV | Missense_Mutation | novel | c.1026N>T | p.Lys342Asn | p.K342N | Q8NBU5 | protein_coding | deleterious(0.03) | benign(0.051) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | novel | c.313N>T | p.Asp105Tyr | p.D105Y | Q8NBU5 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATAD1 | SNV | Missense_Mutation | c.490N>A | p.Asp164Asn | p.D164N | Q8NBU5 | protein_coding | deleterious(0.05) | probably_damaging(0.969) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ATAD1 | SNV | Missense_Mutation | novel | c.773A>C | p.Asn258Thr | p.N258T | Q8NBU5 | protein_coding | tolerated(0.1) | benign(0.216) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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