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Gene: ASF1A |
Gene summary for ASF1A |
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Gene information | Species | Human | Gene symbol | ASF1A | Gene ID | 25842 |
Gene name | anti-silencing function 1A histone chaperone | |
Gene Alias | CGI-98 | |
Cytomap | 6q22.31 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9Y294 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25842 | ASF1A | C51 | Human | Oral cavity | OSCC | 1.02e-04 | 3.56e-01 | 0.2674 |
25842 | ASF1A | C57 | Human | Oral cavity | OSCC | 3.38e-03 | 2.53e-01 | 0.1679 |
25842 | ASF1A | C06 | Human | Oral cavity | OSCC | 9.84e-05 | 1.10e+00 | 0.2699 |
25842 | ASF1A | C08 | Human | Oral cavity | OSCC | 4.62e-28 | 6.20e-01 | 0.1919 |
25842 | ASF1A | LN22 | Human | Oral cavity | OSCC | 6.65e-03 | 8.18e-01 | 0.1733 |
25842 | ASF1A | LN46 | Human | Oral cavity | OSCC | 1.68e-04 | 3.91e-01 | 0.1666 |
25842 | ASF1A | LP17 | Human | Oral cavity | LP | 1.82e-02 | 7.32e-01 | 0.2349 |
25842 | ASF1A | SYSMH1 | Human | Oral cavity | OSCC | 2.06e-07 | 1.61e-01 | 0.1127 |
25842 | ASF1A | SYSMH2 | Human | Oral cavity | OSCC | 1.19e-10 | 3.79e-01 | 0.2326 |
25842 | ASF1A | SYSMH3 | Human | Oral cavity | OSCC | 3.86e-29 | 5.64e-01 | 0.2442 |
25842 | ASF1A | SYSMH6 | Human | Oral cavity | OSCC | 1.41e-11 | 2.04e-01 | 0.1275 |
25842 | ASF1A | P1_cSCC | Human | Skin | cSCC | 6.65e-15 | 6.12e-01 | 0.0292 |
25842 | ASF1A | P2_cSCC | Human | Skin | cSCC | 2.18e-08 | 3.46e-01 | -0.024 |
25842 | ASF1A | P4_cSCC | Human | Skin | cSCC | 8.84e-17 | 4.45e-01 | -0.00290000000000005 |
25842 | ASF1A | P10_cSCC | Human | Skin | cSCC | 1.49e-15 | 5.12e-01 | 0.1017 |
25842 | ASF1A | cSCC_p8 | Human | Skin | cSCC | 1.12e-03 | 3.04e-02 | -0.1971 |
25842 | ASF1A | cSCC_p9 | Human | Skin | cSCC | 1.11e-03 | 3.38e-02 | -0.1991 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00016495 | Liver | Cirrhotic | osteoblast differentiation | 80/4634 | 229/18723 | 3.39e-04 | 2.91e-03 | 80 |
GO:00015035 | Liver | Cirrhotic | ossification | 127/4634 | 408/18723 | 1.89e-03 | 1.19e-02 | 127 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000164911 | Liver | HCC | osteoblast differentiation | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000164910 | Oral cavity | OSCC | osteoblast differentiation | 118/7305 | 229/18723 | 7.51e-05 | 5.85e-04 | 118 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:000150315 | Oral cavity | LP | ossification | 123/4623 | 408/18723 | 6.55e-03 | 3.84e-02 | 123 |
GO:000164916 | Oral cavity | LP | osteoblast differentiation | 73/4623 | 229/18723 | 8.09e-03 | 4.40e-02 | 73 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:000164923 | Skin | cSCC | osteoblast differentiation | 89/4864 | 229/18723 | 1.18e-05 | 1.51e-04 | 89 |
GO:000633812 | Skin | cSCC | chromatin remodeling | 94/4864 | 255/18723 | 7.58e-05 | 7.26e-04 | 94 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:000150323 | Skin | cSCC | ossification | 137/4864 | 408/18723 | 3.39e-04 | 2.68e-03 | 137 |
GO:00711031 | Skin | cSCC | DNA conformation change | 96/4864 | 290/18723 | 3.87e-03 | 2.07e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASF1A | SNV | Missense_Mutation | c.245N>T | p.Gly82Val | p.G82V | Q9Y294 | protein_coding | deleterious(0.03) | benign(0.441) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
ASF1A | insertion | Nonsense_Mutation | novel | c.355_356insTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGT | p.Glu119ValfsTer3 | p.E119Vfs*3 | Q9Y294 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ASF1A | SNV | Missense_Mutation | c.520C>A | p.Leu174Ile | p.L174I | Q9Y294 | protein_coding | tolerated(0.13) | benign(0.231) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ASF1A | SNV | Missense_Mutation | c.160G>A | p.Asp54Asn | p.D54N | Q9Y294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ASF1A | SNV | Missense_Mutation | c.418N>A | p.Leu140Met | p.L140M | Q9Y294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
ASF1A | SNV | Missense_Mutation | rs755432972 | c.199G>A | p.Ala67Thr | p.A67T | Q9Y294 | protein_coding | tolerated(0.23) | probably_damaging(0.926) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASF1A | SNV | Missense_Mutation | c.325G>T | p.Val109Phe | p.V109F | Q9Y294 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ASF1A | SNV | Missense_Mutation | c.274N>A | p.Val92Ile | p.V92I | Q9Y294 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ASF1A | SNV | Missense_Mutation | novel | c.136N>T | p.Gly46Cys | p.G46C | Q9Y294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ASF1A | SNV | Missense_Mutation | novel | c.556N>C | p.Trp186Arg | p.W186R | Q9Y294 | protein_coding | tolerated(0.32) | benign(0.093) | TCGA-DD-AADR-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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