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Gene: ASCL2 |
Gene summary for ASCL2 |
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Gene information | Species | Human | Gene symbol | ASCL2 | Gene ID | 430 |
Gene name | achaete-scute family bHLH transcription factor 2 | |
Gene Alias | ASH2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99929 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
430 | ASCL2 | C46 | Human | Oral cavity | OSCC | 2.44e-44 | 9.35e-01 | 0.1673 |
430 | ASCL2 | C51 | Human | Oral cavity | OSCC | 5.53e-05 | 3.62e-01 | 0.2674 |
430 | ASCL2 | C08 | Human | Oral cavity | OSCC | 1.19e-08 | 2.46e-01 | 0.1919 |
430 | ASCL2 | LN22 | Human | Oral cavity | OSCC | 1.99e-02 | 6.69e-01 | 0.1733 |
430 | ASCL2 | LN46 | Human | Oral cavity | OSCC | 8.37e-24 | 7.10e-01 | 0.1666 |
430 | ASCL2 | LP15 | Human | Oral cavity | LP | 1.52e-05 | 9.99e-01 | 0.2174 |
430 | ASCL2 | SYSMH1 | Human | Oral cavity | OSCC | 9.28e-04 | 1.81e-01 | 0.1127 |
430 | ASCL2 | SYSMH2 | Human | Oral cavity | OSCC | 1.76e-13 | 4.82e-01 | 0.2326 |
430 | ASCL2 | SYSMH3 | Human | Oral cavity | OSCC | 3.63e-17 | 5.81e-01 | 0.2442 |
430 | ASCL2 | SYSMH6 | Human | Oral cavity | OSCC | 8.14e-08 | 3.40e-01 | 0.1275 |
430 | ASCL2 | P2_S3_AK | Human | Skin | AK | 3.57e-02 | 1.17e-01 | -0.3287 |
430 | ASCL2 | P4_S8_cSCC | Human | Skin | cSCC | 3.87e-03 | 2.15e-01 | -0.3095 |
430 | ASCL2 | P5_S10_cSCC | Human | Skin | cSCC | 6.95e-12 | 2.73e-01 | -0.299 |
430 | ASCL2 | P1_cSCC | Human | Skin | cSCC | 2.25e-39 | 1.20e+00 | 0.0292 |
430 | ASCL2 | P2_cSCC | Human | Skin | cSCC | 6.66e-22 | 6.82e-01 | -0.024 |
430 | ASCL2 | P4_cSCC | Human | Skin | cSCC | 3.12e-44 | 8.95e-01 | -0.00290000000000005 |
430 | ASCL2 | P10_cSCC | Human | Skin | cSCC | 1.22e-37 | 1.01e+00 | 0.1017 |
430 | ASCL2 | cSCC_p1 | Human | Skin | cSCC | 4.24e-05 | 2.17e-01 | -0.1916 |
430 | ASCL2 | cSCC_p10 | Human | Skin | cSCC | 4.22e-22 | 4.94e-01 | -0.2095 |
430 | ASCL2 | cSCC_p11 | Human | Skin | cSCC | 2.78e-10 | 3.09e-01 | -0.2102 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0001890 | Colorectum | AD | placenta development | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0001892 | Colorectum | AD | embryonic placenta development | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0036293 | Colorectum | AD | response to decreased oxygen levels | 88/3918 | 322/18723 | 3.42e-03 | 2.49e-02 | 88 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00018901 | Colorectum | SER | placenta development | 43/2897 | 144/18723 | 9.10e-06 | 3.03e-04 | 43 |
GO:00018921 | Colorectum | SER | embryonic placenta development | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00704821 | Colorectum | SER | response to oxygen levels | 79/2897 | 347/18723 | 1.99e-04 | 3.64e-03 | 79 |
GO:00016661 | Colorectum | SER | response to hypoxia | 69/2897 | 307/18723 | 7.07e-04 | 9.39e-03 | 69 |
GO:00362931 | Colorectum | SER | response to decreased oxygen levels | 71/2897 | 322/18723 | 1.04e-03 | 1.22e-02 | 71 |
GO:00017011 | Colorectum | SER | in utero embryonic development | 77/2897 | 367/18723 | 2.77e-03 | 2.48e-02 | 77 |
GO:00614581 | Colorectum | SER | reproductive system development | 87/2897 | 427/18723 | 3.69e-03 | 3.07e-02 | 87 |
GO:00486081 | Colorectum | SER | reproductive structure development | 85/2897 | 424/18723 | 6.33e-03 | 4.56e-02 | 85 |
GO:00018902 | Colorectum | MSS | placenta development | 51/3467 | 144/18723 | 1.10e-06 | 3.77e-05 | 51 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCL2 | SNV | Missense_Mutation | novel | c.127N>T | p.Ala43Ser | p.A43S | Q99929 | protein_coding | tolerated(0.97) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASCL2 | SNV | Missense_Mutation | novel | c.298N>G | p.Arg100Gly | p.R100G | Q99929 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-2Y-A9GW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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