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Gene: ARMCX3 |
Gene summary for ARMCX3 |
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Gene information | Species | Human | Gene symbol | ARMCX3 | Gene ID | 51566 |
Gene name | armadillo repeat containing X-linked 3 | |
Gene Alias | ALEX3 | |
Cytomap | Xq22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCF9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51566 | ARMCX3 | C38 | Human | Oral cavity | OSCC | 1.13e-03 | 7.95e-01 | 0.172 |
51566 | ARMCX3 | C43 | Human | Oral cavity | OSCC | 8.67e-09 | 3.61e-01 | 0.1704 |
51566 | ARMCX3 | C57 | Human | Oral cavity | OSCC | 3.26e-13 | 5.09e-01 | 0.1679 |
51566 | ARMCX3 | C06 | Human | Oral cavity | OSCC | 8.03e-06 | 8.91e-01 | 0.2699 |
51566 | ARMCX3 | C08 | Human | Oral cavity | OSCC | 6.00e-16 | 4.54e-01 | 0.1919 |
51566 | ARMCX3 | C09 | Human | Oral cavity | OSCC | 2.15e-03 | 2.47e-01 | 0.1431 |
51566 | ARMCX3 | LN22 | Human | Oral cavity | OSCC | 1.97e-04 | 4.20e-01 | 0.1733 |
51566 | ARMCX3 | LN46 | Human | Oral cavity | OSCC | 4.72e-02 | 2.37e-01 | 0.1666 |
51566 | ARMCX3 | SYSMH6 | Human | Oral cavity | OSCC | 4.81e-08 | 3.65e-01 | 0.1275 |
51566 | ARMCX3 | PTCwithHT_6 | Human | Thyroid | HT | 3.89e-02 | -2.09e-01 | 0.02 |
51566 | ARMCX3 | male-WTA | Human | Thyroid | PTC | 3.54e-44 | 8.06e-01 | 0.1037 |
51566 | ARMCX3 | PTC01 | Human | Thyroid | PTC | 1.38e-62 | 2.79e+00 | 0.1899 |
51566 | ARMCX3 | PTC04 | Human | Thyroid | PTC | 5.95e-30 | 1.08e+00 | 0.1927 |
51566 | ARMCX3 | PTC05 | Human | Thyroid | PTC | 7.35e-44 | 3.49e+00 | 0.2065 |
51566 | ARMCX3 | PTC06 | Human | Thyroid | PTC | 1.70e-81 | 3.75e+00 | 0.2057 |
51566 | ARMCX3 | PTC07 | Human | Thyroid | PTC | 6.35e-101 | 3.22e+00 | 0.2044 |
51566 | ARMCX3 | ATC09 | Human | Thyroid | ATC | 1.61e-03 | 9.94e-02 | 0.2871 |
51566 | ARMCX3 | ATC11 | Human | Thyroid | ATC | 3.14e-06 | 7.43e-01 | 0.3386 |
51566 | ARMCX3 | ATC12 | Human | Thyroid | ATC | 2.18e-18 | 7.06e-01 | 0.34 |
51566 | ARMCX3 | ATC13 | Human | Thyroid | ATC | 1.28e-37 | 9.58e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516568 | Endometrium | AEH | establishment of organelle localization | 77/2100 | 390/18723 | 4.89e-07 | 1.94e-05 | 77 |
GO:00307058 | Endometrium | AEH | cytoskeleton-dependent intracellular transport | 38/2100 | 195/18723 | 4.72e-04 | 4.91e-03 | 38 |
GO:00080887 | Endometrium | AEH | axo-dendritic transport | 16/2100 | 75/18723 | 8.13e-03 | 4.49e-02 | 16 |
GO:005165613 | Endometrium | EEC | establishment of organelle localization | 75/2168 | 390/18723 | 6.23e-06 | 1.49e-04 | 75 |
GO:003070514 | Endometrium | EEC | cytoskeleton-dependent intracellular transport | 39/2168 | 195/18723 | 4.40e-04 | 4.58e-03 | 39 |
GO:000808813 | Endometrium | EEC | axo-dendritic transport | 17/2168 | 75/18723 | 4.71e-03 | 2.99e-02 | 17 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:00723846 | Esophagus | ESCC | organelle transport along microtubule | 65/8552 | 85/18723 | 6.61e-09 | 1.35e-07 | 65 |
GO:000808810 | Esophagus | ESCC | axo-dendritic transport | 58/8552 | 75/18723 | 2.09e-08 | 4.02e-07 | 58 |
GO:00989304 | Esophagus | ESCC | axonal transport | 49/8552 | 64/18723 | 4.54e-07 | 6.15e-06 | 49 |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:005165411 | Esophagus | ESCC | establishment of mitochondrion localization | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:00346431 | Esophagus | ESCC | establishment of mitochondrion localization, microtubule-mediated | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:00474971 | Esophagus | ESCC | mitochondrion transport along microtubule | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:00516463 | Esophagus | ESCC | mitochondrion localization | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:00109706 | Oral cavity | OSCC | transport along microtubule | 88/7305 | 155/18723 | 5.35e-06 | 6.02e-05 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMCX3 | SNV | Missense_Mutation | c.604G>T | p.Val202Leu | p.V202L | Q9UH62 | protein_coding | deleterious(0.02) | benign(0.101) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMCX3 | SNV | Missense_Mutation | novel | c.120N>T | p.Glu40Asp | p.E40D | Q9UH62 | protein_coding | tolerated(0.37) | benign(0.177) | TCGA-E2-A15K-06 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ARMCX3 | deletion | Frame_Shift_Del | novel | c.597delG | p.Arg199SerfsTer6 | p.R199Sfs*6 | Q9UH62 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ARMCX3 | SNV | Missense_Mutation | novel | c.644N>A | p.Arg215His | p.R215H | Q9UH62 | protein_coding | tolerated(0.08) | probably_damaging(0.93) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ARMCX3 | deletion | Frame_Shift_Del | c.107delN | p.Met38TrpfsTer36 | p.M38Wfs*36 | Q9UH62 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
ARMCX3 | insertion | In_Frame_Ins | novel | c.357_358insTTGTTCTGTTTTCTT | p.Ser119_Pro120insLeuPheCysPheLeu | p.S119_P120insLFCFL | Q9UH62 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ARMCX3 | SNV | Missense_Mutation | c.715N>T | p.His239Tyr | p.H239Y | Q9UH62 | protein_coding | deleterious(0.04) | possibly_damaging(0.53) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ARMCX3 | insertion | Frame_Shift_Ins | novel | c.379_380insT | p.Cys128LeufsTer4 | p.C128Lfs*4 | Q9UH62 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
ARMCX3 | deletion | Frame_Shift_Del | c.107delN | p.Met38TrpfsTer36 | p.M38Wfs*36 | Q9UH62 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ARMCX3 | insertion | Nonsense_Mutation | novel | c.108_109insTAGAGT | p.Glu36_Lys37insTer | p.E36_K37ins* | Q9UH62 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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