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Gene: AMZ2 |
Gene summary for AMZ2 |
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Gene information | Species | Human | Gene symbol | AMZ2 | Gene ID | 51321 |
Gene name | archaelysin family metallopeptidase 2 | |
Gene Alias | AMZ2 | |
Cytomap | 17q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q86W34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51321 | AMZ2 | C04 | Human | Oral cavity | OSCC | 1.78e-23 | 1.10e+00 | 0.2633 |
51321 | AMZ2 | C21 | Human | Oral cavity | OSCC | 4.32e-61 | 1.83e+00 | 0.2678 |
51321 | AMZ2 | C30 | Human | Oral cavity | OSCC | 1.94e-51 | 2.27e+00 | 0.3055 |
51321 | AMZ2 | C38 | Human | Oral cavity | OSCC | 3.08e-20 | 1.43e+00 | 0.172 |
51321 | AMZ2 | C43 | Human | Oral cavity | OSCC | 1.21e-45 | 8.39e-01 | 0.1704 |
51321 | AMZ2 | C46 | Human | Oral cavity | OSCC | 2.17e-34 | 7.06e-01 | 0.1673 |
51321 | AMZ2 | C51 | Human | Oral cavity | OSCC | 1.50e-23 | 8.87e-01 | 0.2674 |
51321 | AMZ2 | C57 | Human | Oral cavity | OSCC | 1.37e-11 | 4.13e-01 | 0.1679 |
51321 | AMZ2 | C06 | Human | Oral cavity | OSCC | 1.51e-13 | 1.46e+00 | 0.2699 |
51321 | AMZ2 | C07 | Human | Oral cavity | OSCC | 1.12e-07 | 9.17e-01 | 0.2491 |
51321 | AMZ2 | C08 | Human | Oral cavity | OSCC | 4.58e-54 | 1.05e+00 | 0.1919 |
51321 | AMZ2 | C09 | Human | Oral cavity | OSCC | 8.14e-22 | 6.40e-01 | 0.1431 |
51321 | AMZ2 | LN22 | Human | Oral cavity | OSCC | 6.06e-08 | 9.47e-01 | 0.1733 |
51321 | AMZ2 | LN38 | Human | Oral cavity | OSCC | 7.35e-06 | 9.65e-01 | 0.168 |
51321 | AMZ2 | LN46 | Human | Oral cavity | OSCC | 5.01e-14 | 4.89e-01 | 0.1666 |
51321 | AMZ2 | LP15 | Human | Oral cavity | LP | 6.84e-09 | 1.43e+00 | 0.2174 |
51321 | AMZ2 | LP17 | Human | Oral cavity | LP | 6.41e-10 | 1.08e+00 | 0.2349 |
51321 | AMZ2 | SYSMH1 | Human | Oral cavity | OSCC | 7.18e-14 | 4.05e-01 | 0.1127 |
51321 | AMZ2 | SYSMH2 | Human | Oral cavity | OSCC | 7.59e-08 | 3.59e-01 | 0.2326 |
51321 | AMZ2 | SYSMH3 | Human | Oral cavity | OSCC | 5.21e-08 | 2.93e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AMZ2 | SNV | Missense_Mutation | c.220N>G | p.Phe74Val | p.F74V | Q86W34 | protein_coding | deleterious(0.01) | benign(0.073) | TCGA-A1-A0SJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | c.525N>A | p.Met175Ile | p.M175I | Q86W34 | protein_coding | deleterious(0.01) | benign(0.214) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AMZ2 | SNV | Missense_Mutation | rs782216581 | c.805N>T | p.Ala269Ser | p.A269S | Q86W34 | protein_coding | tolerated(0.92) | benign(0.011) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMZ2 | SNV | Missense_Mutation | rs782809066 | c.77N>G | p.Tyr26Cys | p.Y26C | Q86W34 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
AMZ2 | SNV | Missense_Mutation | novel | c.368G>T | p.Arg123Ile | p.R123I | Q86W34 | protein_coding | tolerated(0.06) | benign(0.015) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AMZ2 | insertion | Frame_Shift_Ins | novel | c.207_208insCTCTATATAGGAACACGATGTGAATGGAAGAAACCTGTCA | p.Phe70LeufsTer15 | p.F70Lfs*15 | Q86W34 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
AMZ2 | SNV | Missense_Mutation | c.542G>C | p.Arg181Thr | p.R181T | Q86W34 | protein_coding | tolerated(0.07) | possibly_damaging(0.617) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | c.622N>C | p.Asp208His | p.D208H | Q86W34 | protein_coding | tolerated(0.11) | benign(0.067) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
AMZ2 | SNV | Missense_Mutation | c.684N>A | p.Asp228Glu | p.D228E | Q86W34 | protein_coding | tolerated(0.41) | benign(0.046) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AMZ2 | SNV | Missense_Mutation | novel | c.450N>G | p.Ile150Met | p.I150M | Q86W34 | protein_coding | deleterious(0.01) | possibly_damaging(0.535) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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