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Gene: ABT1 |
Gene summary for ABT1 |
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Gene information | Species | Human | Gene symbol | ABT1 | Gene ID | 29777 |
Gene name | activator of basal transcription 1 | |
Gene Alias | Esf2 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000028 | UniProtAcc | A0A024R029 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29777 | ABT1 | C21 | Human | Oral cavity | OSCC | 2.27e-51 | 1.59e+00 | 0.2678 |
29777 | ABT1 | C30 | Human | Oral cavity | OSCC | 9.67e-40 | 1.80e+00 | 0.3055 |
29777 | ABT1 | C38 | Human | Oral cavity | OSCC | 4.95e-10 | 1.25e+00 | 0.172 |
29777 | ABT1 | C43 | Human | Oral cavity | OSCC | 2.09e-18 | 3.68e-01 | 0.1704 |
29777 | ABT1 | C46 | Human | Oral cavity | OSCC | 8.19e-28 | 6.39e-01 | 0.1673 |
29777 | ABT1 | C51 | Human | Oral cavity | OSCC | 3.53e-08 | 5.62e-01 | 0.2674 |
29777 | ABT1 | C57 | Human | Oral cavity | OSCC | 1.69e-25 | 8.12e-01 | 0.1679 |
29777 | ABT1 | C06 | Human | Oral cavity | OSCC | 2.57e-08 | 1.30e+00 | 0.2699 |
29777 | ABT1 | C07 | Human | Oral cavity | OSCC | 4.59e-02 | 9.99e-01 | 0.2491 |
29777 | ABT1 | C08 | Human | Oral cavity | OSCC | 2.63e-40 | 7.42e-01 | 0.1919 |
29777 | ABT1 | C09 | Human | Oral cavity | OSCC | 7.88e-06 | 3.39e-01 | 0.1431 |
29777 | ABT1 | LN22 | Human | Oral cavity | OSCC | 3.05e-14 | 1.36e+00 | 0.1733 |
29777 | ABT1 | LN38 | Human | Oral cavity | OSCC | 6.79e-04 | 8.00e-01 | 0.168 |
29777 | ABT1 | LN46 | Human | Oral cavity | OSCC | 1.31e-13 | 6.63e-01 | 0.1666 |
29777 | ABT1 | LP15 | Human | Oral cavity | LP | 6.28e-06 | 1.15e+00 | 0.2174 |
29777 | ABT1 | SYSMH2 | Human | Oral cavity | OSCC | 1.93e-21 | 6.50e-01 | 0.2326 |
29777 | ABT1 | SYSMH3 | Human | Oral cavity | OSCC | 1.54e-18 | 5.35e-01 | 0.2442 |
29777 | ABT1 | SYSMH4 | Human | Oral cavity | OSCC | 1.68e-04 | 1.19e-01 | 0.1226 |
29777 | ABT1 | SYSMH6 | Human | Oral cavity | OSCC | 1.19e-06 | 2.88e-01 | 0.1275 |
29777 | ABT1 | P4_S8_cSCC | Human | Skin | cSCC | 9.89e-09 | 1.48e-01 | -0.3095 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:0042255111 | Esophagus | ESCC | ribosome assembly | 50/8552 | 61/18723 | 5.66e-09 | 1.17e-07 | 50 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00004783 | Esophagus | ESCC | endonucleolytic cleavage involved in rRNA processing | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00004793 | Esophagus | ESCC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABT1 | SNV | Missense_Mutation | novel | c.378N>A | p.His126Gln | p.H126Q | Q9ULW3 | protein_coding | deleterious(0.01) | probably_damaging(0.931) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
ABT1 | SNV | Missense_Mutation | c.310G>T | p.Asp104Tyr | p.D104Y | Q9ULW3 | protein_coding | deleterious(0.04) | probably_damaging(0.935) | TCGA-AN-A0XS-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ABT1 | SNV | Missense_Mutation | novel | c.463N>T | p.His155Tyr | p.H155Y | Q9ULW3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ABT1 | SNV | Missense_Mutation | rs782670086 | c.481G>A | p.Ala161Thr | p.A161T | Q9ULW3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ABT1 | SNV | Missense_Mutation | novel | c.238N>C | p.Glu80Gln | p.E80Q | Q9ULW3 | protein_coding | deleterious(0.02) | possibly_damaging(0.702) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ABT1 | SNV | Missense_Mutation | rs782097640 | c.539N>A | p.Arg180His | p.R180H | Q9ULW3 | protein_coding | deleterious(0.03) | benign(0.207) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ABT1 | SNV | Missense_Mutation | novel | c.120G>T | p.Lys40Asn | p.K40N | Q9ULW3 | protein_coding | tolerated(0.09) | benign(0.286) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ABT1 | SNV | Missense_Mutation | c.292A>C | p.Lys98Gln | p.K98Q | Q9ULW3 | protein_coding | tolerated(0.26) | benign(0.216) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ABT1 | SNV | Missense_Mutation | rs374428829 | c.275N>T | p.Ala92Val | p.A92V | Q9ULW3 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABT1 | SNV | Missense_Mutation | c.374N>A | p.Leu125Gln | p.L125Q | Q9ULW3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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