Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ZXDC_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZXDC_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZXDC_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZXDC_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZXDC | SNV | Missense_Mutation | rs758081002 | c.2426N>T | p.Ser809Leu | p.S809L | Q2QGD7 | protein_coding | tolerated(1) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZXDC | SNV | Missense_Mutation | novel | c.905C>G | p.Pro302Arg | p.P302R | Q2QGD7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | novel | c.1069N>T | p.Pro357Ser | p.P357S | Q2QGD7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | | c.1870N>A | p.Pro624Thr | p.P624T | Q2QGD7 | protein_coding | tolerated(0.08) | benign(0.072) | TCGA-AO-A12F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZXDC | SNV | Missense_Mutation | | c.2271N>G | p.Phe757Leu | p.F757L | Q2QGD7 | protein_coding | tolerated(0.74) | benign(0) | TCGA-B6-A1KC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZXDC | insertion | Frame_Shift_Ins | novel | c.1069_1070insATTT | p.Pro357HisfsTer6 | p.P357Hfs*6 | Q2QGD7 | protein_coding | | | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | deletion | Frame_Shift_Del | novel | c.2138delN | p.Gly713AlafsTer12 | p.G713Afs*12 | Q2QGD7 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZXDC | SNV | Missense_Mutation | rs750723904 | c.1414A>G | p.Met472Val | p.M472V | Q2QGD7 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZXDC | SNV | Missense_Mutation | novel | c.752N>A | p.Thr251Lys | p.T251K | Q2QGD7 | protein_coding | deleterious(0.01) | possibly_damaging(0.883) | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | novel | c.2161G>T | p.Ala721Ser | p.A721S | Q2QGD7 | protein_coding | tolerated(0.07) | benign(0.352) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |