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Gene: ZNF821 |
Gene summary for ZNF821 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF821 | Gene ID | 55565 |
Gene name | zinc finger protein 821 | |
Gene Alias | ZNF821 | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O75541 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55565 | ZNF821 | P127T-E | Human | Esophagus | ESCC | 3.49e-11 | 1.79e-01 | 0.0826 |
55565 | ZNF821 | P128T-E | Human | Esophagus | ESCC | 1.45e-17 | 3.89e-01 | 0.1241 |
55565 | ZNF821 | P130T-E | Human | Esophagus | ESCC | 3.75e-26 | 4.89e-01 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF821 | SNV | Missense_Mutation | c.1174N>C | p.Glu392Gln | p.E392Q | O75541 | protein_coding | tolerated_low_confidence(0.05) | benign(0.201) | TCGA-A2-A0CW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
ZNF821 | SNV | Missense_Mutation | novel | c.1205C>T | p.Ala402Val | p.A402V | O75541 | protein_coding | tolerated_low_confidence(0.05) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF821 | SNV | Missense_Mutation | c.1069G>C | p.Glu357Gln | p.E357Q | O75541 | protein_coding | tolerated(0.07) | probably_damaging(0.986) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF821 | SNV | Missense_Mutation | c.893T>C | p.Met298Thr | p.M298T | O75541 | protein_coding | deleterious(0.01) | benign(0.258) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF821 | insertion | Frame_Shift_Ins | novel | c.456_457insGAGTTCTGCTTTCTGAAGTCAA | p.Pro153GlufsTer15 | p.P153Efs*15 | O75541 | protein_coding | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ZNF821 | insertion | Frame_Shift_Ins | novel | c.603_604insACCTGGGTGGAAATTTTCAGACAGTGGCTTCTGGTGGCTTGCC | p.Leu202ThrfsTer26 | p.L202Tfs*26 | O75541 | protein_coding | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF821 | SNV | Missense_Mutation | c.327N>C | p.Leu109Phe | p.L109F | O75541 | protein_coding | tolerated(0.23) | benign(0.326) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ZNF821 | SNV | Missense_Mutation | rs377750355 | c.439N>A | p.Ala147Thr | p.A147T | O75541 | protein_coding | tolerated(0.29) | benign(0.041) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF821 | SNV | Missense_Mutation | c.854G>A | p.Arg285Gln | p.R285Q | O75541 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF821 | SNV | Missense_Mutation | novel | c.731A>C | p.Tyr244Ser | p.Y244S | O75541 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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