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Gene: ZNF706 |
Gene summary for ZNF706 |
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Gene information | Species | Human | Gene symbol | ZNF706 | Gene ID | 51123 |
Gene name | zinc finger protein 706 | |
Gene Alias | HSPC038 | |
Cytomap | 8q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y5V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51123 | ZNF706 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.88e-33 | -2.56e-01 | -0.1883 |
51123 | ZNF706 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.92e-28 | -2.27e-01 | -0.1934 |
51123 | ZNF706 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.15e-44 | -2.99e-01 | -0.1917 |
51123 | ZNF706 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 8.52e-37 | -3.40e-01 | -0.1916 |
51123 | ZNF706 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.69e-06 | -4.27e-03 | -0.1269 |
51123 | ZNF706 | LZE2T | Human | Esophagus | ESCC | 2.35e-14 | 2.51e+00 | 0.082 |
51123 | ZNF706 | LZE4T | Human | Esophagus | ESCC | 1.71e-34 | 1.74e+00 | 0.0811 |
51123 | ZNF706 | LZE5T | Human | Esophagus | ESCC | 1.60e-02 | 8.19e-01 | 0.0514 |
51123 | ZNF706 | LZE7T | Human | Esophagus | ESCC | 4.04e-10 | 1.08e+00 | 0.0667 |
51123 | ZNF706 | LZE8T | Human | Esophagus | ESCC | 1.38e-11 | 8.34e-01 | 0.067 |
51123 | ZNF706 | LZE20T | Human | Esophagus | ESCC | 1.19e-17 | 1.06e+00 | 0.0662 |
51123 | ZNF706 | LZE22D1 | Human | Esophagus | HGIN | 1.74e-02 | 3.26e-01 | 0.0595 |
51123 | ZNF706 | LZE22T | Human | Esophagus | ESCC | 1.79e-05 | 1.09e+00 | 0.068 |
51123 | ZNF706 | LZE24D1 | Human | Esophagus | HGIN | 5.58e-04 | 8.19e-01 | 0.054 |
51123 | ZNF706 | LZE24T | Human | Esophagus | ESCC | 2.48e-31 | 1.66e+00 | 0.0596 |
51123 | ZNF706 | LZE21T | Human | Esophagus | ESCC | 3.46e-03 | 8.08e-01 | 0.0655 |
51123 | ZNF706 | LZE6T | Human | Esophagus | ESCC | 2.48e-06 | 4.79e-01 | 0.0845 |
51123 | ZNF706 | P1T-E | Human | Esophagus | ESCC | 4.08e-17 | 1.16e+00 | 0.0875 |
51123 | ZNF706 | P2T-E | Human | Esophagus | ESCC | 2.04e-46 | 1.23e+00 | 0.1177 |
51123 | ZNF706 | P4T-E | Human | Esophagus | ESCC | 4.28e-71 | 2.47e+00 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:000641714 | Breast | IDC | regulation of translation | 74/1434 | 468/18723 | 1.67e-09 | 1.53e-07 | 74 |
GO:000641724 | Breast | DCIS | regulation of translation | 72/1390 | 468/18723 | 2.46e-09 | 2.17e-07 | 72 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00064174 | Colorectum | FAP | regulation of translation | 111/2622 | 468/18723 | 8.47e-09 | 1.13e-06 | 111 |
GO:0019827 | Colorectum | FAP | stem cell population maintenance | 33/2622 | 131/18723 | 4.61e-04 | 5.39e-03 | 33 |
GO:0098727 | Colorectum | FAP | maintenance of cell number | 33/2622 | 134/18723 | 7.09e-04 | 7.64e-03 | 33 |
GO:000641716 | Endometrium | AEH | regulation of translation | 94/2100 | 468/18723 | 1.14e-08 | 7.62e-07 | 94 |
GO:000641717 | Endometrium | EEC | regulation of translation | 94/2168 | 468/18723 | 5.37e-08 | 2.88e-06 | 94 |
GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
GO:00987278 | Esophagus | HGIN | maintenance of cell number | 39/2587 | 134/18723 | 3.02e-06 | 1.03e-04 | 39 |
GO:20000362 | Esophagus | HGIN | regulation of stem cell population maintenance | 11/2587 | 33/18723 | 3.55e-03 | 3.26e-02 | 11 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:20000361 | Esophagus | ESCC | regulation of stem cell population maintenance | 23/8552 | 33/18723 | 4.57e-03 | 1.78e-02 | 23 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF706 | SNV | Missense_Mutation | novel | c.41N>T | p.Asn14Ile | p.N14I | Q9Y5V0 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF706 | SNV | Missense_Mutation | novel | c.21A>C | p.Lys7Asn | p.K7N | Q9Y5V0 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF706 | SNV | Missense_Mutation | novel | c.109N>G | p.Leu37Val | p.L37V | Q9Y5V0 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-DD-AAE7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF706 | SNV | Missense_Mutation | novel | c.134G>C | p.Arg45Thr | p.R45T | Q9Y5V0 | protein_coding | deleterious(0.02) | benign(0.044) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF706 | SNV | Missense_Mutation | novel | c.202N>T | p.Pro68Ser | p.P68S | Q9Y5V0 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-60-2695-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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