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Gene: ZNF664 |
Gene summary for ZNF664 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF664 | Gene ID | 144348 |
Gene name | zinc finger protein 664 | |
Gene Alias | ZFOC1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RBR7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
144348 | ZNF664 | P37T-E | Human | Esophagus | ESCC | 5.36e-23 | 5.44e-01 | 0.1371 |
144348 | ZNF664 | P38T-E | Human | Esophagus | ESCC | 1.64e-06 | 3.09e-01 | 0.127 |
144348 | ZNF664 | P39T-E | Human | Esophagus | ESCC | 2.86e-24 | 3.02e-01 | 0.0894 |
144348 | ZNF664 | P40T-E | Human | Esophagus | ESCC | 2.22e-11 | 3.58e-01 | 0.109 |
144348 | ZNF664 | P42T-E | Human | Esophagus | ESCC | 3.15e-05 | 2.10e-01 | 0.1175 |
144348 | ZNF664 | P44T-E | Human | Esophagus | ESCC | 2.77e-03 | 2.41e-01 | 0.1096 |
144348 | ZNF664 | P47T-E | Human | Esophagus | ESCC | 1.98e-12 | 1.53e-01 | 0.1067 |
144348 | ZNF664 | P48T-E | Human | Esophagus | ESCC | 6.50e-25 | 4.36e-01 | 0.0959 |
144348 | ZNF664 | P49T-E | Human | Esophagus | ESCC | 1.30e-11 | 1.27e+00 | 0.1768 |
144348 | ZNF664 | P52T-E | Human | Esophagus | ESCC | 1.92e-15 | 2.60e-01 | 0.1555 |
144348 | ZNF664 | P54T-E | Human | Esophagus | ESCC | 1.21e-40 | 8.94e-01 | 0.0975 |
144348 | ZNF664 | P56T-E | Human | Esophagus | ESCC | 1.20e-09 | 1.58e+00 | 0.1613 |
144348 | ZNF664 | P57T-E | Human | Esophagus | ESCC | 2.84e-23 | 3.93e-01 | 0.0926 |
144348 | ZNF664 | P61T-E | Human | Esophagus | ESCC | 1.76e-18 | 5.51e-01 | 0.099 |
144348 | ZNF664 | P62T-E | Human | Esophagus | ESCC | 2.71e-17 | 2.91e-01 | 0.1302 |
144348 | ZNF664 | P65T-E | Human | Esophagus | ESCC | 2.52e-20 | 2.79e-01 | 0.0978 |
144348 | ZNF664 | P74T-E | Human | Esophagus | ESCC | 2.69e-21 | 6.28e-01 | 0.1479 |
144348 | ZNF664 | P75T-E | Human | Esophagus | ESCC | 8.98e-29 | 4.72e-01 | 0.1125 |
144348 | ZNF664 | P76T-E | Human | Esophagus | ESCC | 6.72e-21 | 3.93e-01 | 0.1207 |
144348 | ZNF664 | P79T-E | Human | Esophagus | ESCC | 8.64e-39 | 7.71e-01 | 0.1154 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF664 | SNV | Missense_Mutation | novel | c.82N>A | p.Glu28Lys | p.E28K | Q8N3J9 | protein_coding | deleterious(0.04) | benign(0.364) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZNF664 | SNV | Missense_Mutation | c.556N>A | p.Leu186Ile | p.L186I | Q8N3J9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF664 | SNV | Missense_Mutation | c.656N>T | p.Arg219Ile | p.R219I | Q8N3J9 | protein_coding | tolerated(0.05) | possibly_damaging(0.802) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF664 | SNV | Missense_Mutation | c.656N>A | p.Arg219Lys | p.R219K | Q8N3J9 | protein_coding | deleterious(0.04) | possibly_damaging(0.726) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF664 | SNV | Missense_Mutation | c.36N>A | p.Phe12Leu | p.F12L | Q8N3J9 | protein_coding | deleterious(0.04) | possibly_damaging(0.703) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF664 | SNV | Missense_Mutation | novel | c.718A>G | p.Thr240Ala | p.T240A | Q8N3J9 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF664 | SNV | Missense_Mutation | novel | c.286N>C | p.Phe96Leu | p.F96L | Q8N3J9 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF664 | SNV | Missense_Mutation | c.619G>T | p.Ala207Ser | p.A207S | Q8N3J9 | protein_coding | tolerated(0.19) | benign(0.058) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF664 | SNV | Missense_Mutation | novel | c.52N>A | p.Leu18Ile | p.L18I | Q8N3J9 | protein_coding | deleterious(0) | benign(0.427) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF664 | SNV | Missense_Mutation | rs767125869 | c.551N>T | p.Ser184Leu | p.S184L | Q8N3J9 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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