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Gene: ZNF654 |
Gene summary for ZNF654 |
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Gene information | Species | Human | Gene symbol | ZNF654 | Gene ID | 55279 |
Gene name | zinc finger protein 654 | |
Gene Alias | ZNF654 | |
Cytomap | 3p11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55279 | ZNF654 | HTA12-23-1 | Human | Pancreas | PDAC | 5.63e-04 | 5.26e-01 | 0.3405 |
55279 | ZNF654 | HTA12-26-1 | Human | Pancreas | PDAC | 2.56e-09 | 5.35e-01 | 0.3728 |
55279 | ZNF654 | HTA12-29-1 | Human | Pancreas | PDAC | 6.88e-17 | 5.03e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF654 | SNV | Missense_Mutation | c.1331C>T | p.Ser444Leu | p.S444L | Q8IZM8 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | rs758133144 | c.115C>T | p.Leu39Phe | p.L39F | Q8IZM8 | protein_coding | tolerated(0.18) | probably_damaging(0.993) | TCGA-AR-A1AY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Doxorubicin | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.852G>T | p.Gln284His | p.Q284H | Q8IZM8 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
ZNF654 | SNV | Missense_Mutation | novel | c.986N>T | p.Ser329Leu | p.S329L | Q8IZM8 | protein_coding | tolerated(0.17) | benign(0.216) | TCGA-ZJ-AAXI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | rs773897741 | c.1189N>A | p.Glu397Lys | p.E397K | Q8IZM8 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | c.860A>C | p.Gln287Pro | p.Q287P | Q8IZM8 | protein_coding | deleterious(0.02) | benign(0.091) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | novel | c.75N>G | p.Phe25Leu | p.F25L | Q8IZM8 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | c.481G>C | p.Gly161Arg | p.G161R | Q8IZM8 | protein_coding | tolerated(0.09) | benign(0.07) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | rs374266455 | c.1606N>A | p.Val536Met | p.V536M | Q8IZM8 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF654 | SNV | Missense_Mutation | c.672N>A | p.His224Gln | p.H224Q | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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