![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF24 |
Gene summary for ZNF24 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF24 | Gene ID | 7572 |
Gene name | zinc finger protein 24 | |
Gene Alias | KOX17 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17028 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7572 | ZNF24 | P104T-E | Human | Esophagus | ESCC | 1.04e-02 | 3.41e-01 | 0.0931 |
7572 | ZNF24 | P107T-E | Human | Esophagus | ESCC | 2.13e-26 | 5.50e-01 | 0.171 |
7572 | ZNF24 | P126T-E | Human | Esophagus | ESCC | 1.58e-04 | 5.61e-01 | 0.1125 |
7572 | ZNF24 | P127T-E | Human | Esophagus | ESCC | 2.44e-22 | 3.31e-01 | 0.0826 |
7572 | ZNF24 | P128T-E | Human | Esophagus | ESCC | 1.14e-38 | 1.30e+00 | 0.1241 |
7572 | ZNF24 | P130T-E | Human | Esophagus | ESCC | 8.75e-33 | 8.00e-01 | 0.1676 |
7572 | ZNF24 | S43 | Human | Liver | Cirrhotic | 6.48e-06 | -1.79e-01 | -0.0187 |
7572 | ZNF24 | HCC1_Meng | Human | Liver | HCC | 7.85e-65 | 2.50e-02 | 0.0246 |
7572 | ZNF24 | HCC2_Meng | Human | Liver | HCC | 9.19e-16 | -8.71e-02 | 0.0107 |
7572 | ZNF24 | cirrhotic1 | Human | Liver | Cirrhotic | 7.08e-03 | 1.72e-01 | 0.0202 |
7572 | ZNF24 | HCC1 | Human | Liver | HCC | 2.13e-02 | 2.99e+00 | 0.5336 |
7572 | ZNF24 | HCC2 | Human | Liver | HCC | 1.46e-12 | 3.60e+00 | 0.5341 |
7572 | ZNF24 | Pt13.b | Human | Liver | HCC | 5.94e-13 | 1.31e-01 | 0.0251 |
7572 | ZNF24 | Pt14.a | Human | Liver | HCC | 3.18e-03 | 2.26e-01 | 0.0169 |
7572 | ZNF24 | S014 | Human | Liver | HCC | 6.40e-18 | 9.75e-01 | 0.2254 |
7572 | ZNF24 | S015 | Human | Liver | HCC | 3.01e-17 | 1.04e+00 | 0.2375 |
7572 | ZNF24 | S016 | Human | Liver | HCC | 7.76e-15 | 8.53e-01 | 0.2243 |
7572 | ZNF24 | S027 | Human | Liver | HCC | 1.62e-06 | 9.70e-01 | 0.2446 |
7572 | ZNF24 | S028 | Human | Liver | HCC | 1.28e-18 | 1.08e+00 | 0.2503 |
7572 | ZNF24 | S029 | Human | Liver | HCC | 4.56e-18 | 1.32e+00 | 0.2581 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:00072722 | Oral cavity | NEOLP | ensheathment of neurons | 24/2005 | 136/18723 | 9.59e-03 | 4.53e-02 | 24 |
GO:00083662 | Oral cavity | NEOLP | axon ensheathment | 24/2005 | 136/18723 | 9.59e-03 | 4.53e-02 | 24 |
GO:00425522 | Prostate | Tumor | myelination | 34/3246 | 134/18723 | 1.19e-02 | 4.85e-02 | 34 |
GO:004255221 | Skin | cSCC | myelination | 51/4864 | 134/18723 | 1.37e-03 | 8.70e-03 | 51 |
GO:000727221 | Skin | cSCC | ensheathment of neurons | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:000836621 | Skin | cSCC | axon ensheathment | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF24 | SNV | Missense_Mutation | c.527T>G | p.Leu176Arg | p.L176R | P17028 | protein_coding | tolerated(0.06) | possibly_damaging(0.879) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF24 | insertion | Frame_Shift_Ins | novel | c.999_1000insGAAACAGAAAATGTAAATATCATTCATTATCTATTAAGGGAAAAAGAAA | p.Pro334GlufsTer19 | p.P334Efs*19 | P17028 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF24 | deletion | Frame_Shift_Del | novel | c.15delN | p.Val6TrpfsTer19 | p.V6Wfs*19 | P17028 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF24 | SNV | Missense_Mutation | rs757349943 | c.155G>A | p.Arg52Gln | p.R52Q | P17028 | protein_coding | deleterious(0) | benign(0.38) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | c.980N>T | p.Arg327Ile | p.R327I | P17028 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF24 | SNV | Missense_Mutation | c.841N>C | p.Cys281Arg | p.C281R | P17028 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF24 | SNV | Missense_Mutation | c.1048N>A | p.Leu350Ile | p.L350I | P17028 | protein_coding | deleterious(0.01) | possibly_damaging(0.722) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF24 | SNV | Missense_Mutation | rs781423777 | c.434N>A | p.Arg145Gln | p.R145Q | P17028 | protein_coding | tolerated(0.64) | benign(0.045) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | novel | c.354N>T | p.Glu118Asp | p.E118D | P17028 | protein_coding | tolerated(0.08) | possibly_damaging(0.458) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF24 | SNV | Missense_Mutation | c.959C>T | p.Ser320Leu | p.S320L | P17028 | protein_coding | deleterious(0) | possibly_damaging(0.456) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |