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Gene: ZFAND1 |
Gene summary for ZFAND1 |
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Gene information | Species | Human | Gene symbol | ZFAND1 | Gene ID | 79752 |
Gene name | zinc finger AN1-type containing 1 | |
Gene Alias | ZFAND1 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TCF1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79752 | ZFAND1 | P107T-E | Human | Esophagus | ESCC | 4.25e-42 | 1.22e+00 | 0.171 |
79752 | ZFAND1 | P126T-E | Human | Esophagus | ESCC | 2.49e-08 | 6.73e-01 | 0.1125 |
79752 | ZFAND1 | P127T-E | Human | Esophagus | ESCC | 6.71e-29 | 2.46e-01 | 0.0826 |
79752 | ZFAND1 | P128T-E | Human | Esophagus | ESCC | 1.97e-48 | 1.78e+00 | 0.1241 |
79752 | ZFAND1 | P130T-E | Human | Esophagus | ESCC | 6.32e-44 | 1.05e+00 | 0.1676 |
79752 | ZFAND1 | HCC1_Meng | Human | Liver | HCC | 8.63e-78 | 5.21e-01 | 0.0246 |
79752 | ZFAND1 | HCC2_Meng | Human | Liver | HCC | 1.34e-29 | 1.08e-01 | 0.0107 |
79752 | ZFAND1 | cirrhotic2 | Human | Liver | Cirrhotic | 3.07e-03 | 8.50e-02 | 0.0201 |
79752 | ZFAND1 | HCC2 | Human | Liver | HCC | 1.15e-04 | 3.37e+00 | 0.5341 |
79752 | ZFAND1 | Pt13.b | Human | Liver | HCC | 3.04e-11 | 1.35e-01 | 0.0251 |
79752 | ZFAND1 | Pt14.b | Human | Liver | HCC | 2.21e-03 | 1.38e-01 | 0.018 |
79752 | ZFAND1 | S014 | Human | Liver | HCC | 5.79e-41 | 1.51e+00 | 0.2254 |
79752 | ZFAND1 | S015 | Human | Liver | HCC | 7.08e-27 | 1.64e+00 | 0.2375 |
79752 | ZFAND1 | S016 | Human | Liver | HCC | 4.07e-43 | 1.46e+00 | 0.2243 |
79752 | ZFAND1 | S027 | Human | Liver | HCC | 3.20e-11 | 1.14e+00 | 0.2446 |
79752 | ZFAND1 | S028 | Human | Liver | HCC | 3.10e-24 | 1.24e+00 | 0.2503 |
79752 | ZFAND1 | S029 | Human | Liver | HCC | 1.07e-27 | 1.67e+00 | 0.2581 |
79752 | ZFAND1 | C04 | Human | Oral cavity | OSCC | 4.08e-24 | 1.64e+00 | 0.2633 |
79752 | ZFAND1 | C21 | Human | Oral cavity | OSCC | 3.00e-42 | 1.51e+00 | 0.2678 |
79752 | ZFAND1 | C30 | Human | Oral cavity | OSCC | 1.46e-33 | 1.68e+00 | 0.3055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:19030089 | Esophagus | HGIN | organelle disassembly | 36/2587 | 114/18723 | 8.60e-07 | 3.58e-05 | 36 |
GO:003238617 | Esophagus | HGIN | regulation of intracellular transport | 79/2587 | 337/18723 | 1.11e-06 | 4.36e-05 | 79 |
GO:00712439 | Esophagus | HGIN | cellular response to arsenic-containing substance | 12/2587 | 20/18723 | 2.02e-06 | 7.39e-05 | 12 |
GO:003315720 | Esophagus | HGIN | regulation of intracellular protein transport | 58/2587 | 229/18723 | 2.29e-06 | 8.29e-05 | 58 |
GO:190495120 | Esophagus | HGIN | positive regulation of establishment of protein localization | 73/2587 | 319/18723 | 6.99e-06 | 2.14e-04 | 73 |
GO:003238820 | Esophagus | HGIN | positive regulation of intracellular transport | 51/2587 | 202/18723 | 1.00e-05 | 2.92e-04 | 51 |
GO:00466859 | Esophagus | HGIN | response to arsenic-containing substance | 15/2587 | 33/18723 | 1.08e-05 | 3.10e-04 | 15 |
GO:009031616 | Esophagus | HGIN | positive regulation of intracellular protein transport | 42/2587 | 160/18723 | 2.18e-05 | 5.78e-04 | 42 |
GO:005122220 | Esophagus | HGIN | positive regulation of protein transport | 67/2587 | 303/18723 | 5.13e-05 | 1.22e-03 | 67 |
GO:003298415 | Esophagus | HGIN | protein-containing complex disassembly | 50/2587 | 224/18723 | 3.43e-04 | 5.56e-03 | 50 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFAND1 | SNV | Missense_Mutation | c.283N>C | p.Asp95His | p.D95H | Q8TCF1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFAND1 | SNV | Missense_Mutation | c.124N>T | p.His42Tyr | p.H42Y | Q8TCF1 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZFAND1 | SNV | Missense_Mutation | novel | c.739N>G | p.Asn247Asp | p.N247D | Q8TCF1 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFAND1 | SNV | Missense_Mutation | c.96N>G | p.Phe32Leu | p.F32L | Q8TCF1 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZFAND1 | SNV | Missense_Mutation | novel | c.64C>A | p.Pro22Thr | p.P22T | Q8TCF1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZFAND1 | SNV | Missense_Mutation | novel | c.350N>G | p.Asp117Gly | p.D117G | Q8TCF1 | protein_coding | tolerated(0.06) | benign(0.202) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZFAND1 | SNV | Missense_Mutation | c.143N>A | p.Thr48Asn | p.T48N | Q8TCF1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZFAND1 | SNV | Missense_Mutation | novel | c.593C>A | p.Ser198Tyr | p.S198Y | Q8TCF1 | protein_coding | deleterious(0.01) | possibly_damaging(0.732) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFAND1 | SNV | Missense_Mutation | novel | c.410G>T | p.Ser137Ile | p.S137I | Q8TCF1 | protein_coding | tolerated(0.06) | possibly_damaging(0.467) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFAND1 | SNV | Missense_Mutation | novel | c.773N>T | p.Gln258Leu | p.Q258L | Q8TCF1 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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