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Gene: ZDHHC7 |
Gene summary for ZDHHC7 |
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Gene information | Species | Human | Gene symbol | ZDHHC7 | Gene ID | 55625 |
Gene name | zinc finger DHHC-type palmitoyltransferase 7 | |
Gene Alias | DHHC7 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001738 | UniProtAcc | Q9NXF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55625 | ZDHHC7 | P62T-E | Human | Esophagus | ESCC | 8.61e-71 | 1.17e+00 | 0.1302 |
55625 | ZDHHC7 | P65T-E | Human | Esophagus | ESCC | 3.15e-19 | 3.90e-01 | 0.0978 |
55625 | ZDHHC7 | P74T-E | Human | Esophagus | ESCC | 8.96e-08 | 2.67e-01 | 0.1479 |
55625 | ZDHHC7 | P75T-E | Human | Esophagus | ESCC | 1.29e-33 | 6.44e-01 | 0.1125 |
55625 | ZDHHC7 | P76T-E | Human | Esophagus | ESCC | 4.90e-11 | 1.71e-01 | 0.1207 |
55625 | ZDHHC7 | P79T-E | Human | Esophagus | ESCC | 6.57e-18 | 2.68e-01 | 0.1154 |
55625 | ZDHHC7 | P80T-E | Human | Esophagus | ESCC | 1.29e-20 | 5.69e-01 | 0.155 |
55625 | ZDHHC7 | P82T-E | Human | Esophagus | ESCC | 3.70e-12 | 4.59e-01 | 0.1072 |
55625 | ZDHHC7 | P83T-E | Human | Esophagus | ESCC | 7.50e-13 | 4.17e-01 | 0.1738 |
55625 | ZDHHC7 | P84T-E | Human | Esophagus | ESCC | 2.86e-05 | 4.01e-01 | 0.0933 |
55625 | ZDHHC7 | P89T-E | Human | Esophagus | ESCC | 7.55e-05 | 3.19e-01 | 0.1752 |
55625 | ZDHHC7 | P94T-E | Human | Esophagus | ESCC | 4.85e-04 | 4.68e-01 | 0.0879 |
55625 | ZDHHC7 | P104T-E | Human | Esophagus | ESCC | 2.99e-03 | 3.31e-01 | 0.0931 |
55625 | ZDHHC7 | P107T-E | Human | Esophagus | ESCC | 6.84e-09 | 1.83e-01 | 0.171 |
55625 | ZDHHC7 | P126T-E | Human | Esophagus | ESCC | 1.01e-06 | 8.08e-01 | 0.1125 |
55625 | ZDHHC7 | P127T-E | Human | Esophagus | ESCC | 2.83e-19 | 4.12e-01 | 0.0826 |
55625 | ZDHHC7 | P128T-E | Human | Esophagus | ESCC | 9.57e-12 | 4.50e-01 | 0.1241 |
55625 | ZDHHC7 | P130T-E | Human | Esophagus | ESCC | 1.67e-44 | 8.35e-01 | 0.1676 |
55625 | ZDHHC7 | HCC1_Meng | Human | Liver | HCC | 1.10e-13 | -1.67e-02 | 0.0246 |
55625 | ZDHHC7 | HCC2_Meng | Human | Liver | HCC | 3.55e-25 | 1.57e-01 | 0.0107 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0150105 | Colorectum | AD | protein localization to cell-cell junction | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
GO:0001738 | Colorectum | AD | morphogenesis of a polarized epithelium | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0030859 | Colorectum | AD | polarized epithelial cell differentiation | 11/3918 | 24/18723 | 5.43e-03 | 3.55e-02 | 11 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:00098954 | Colorectum | FAP | negative regulation of catabolic process | 91/2622 | 320/18723 | 9.66e-12 | 4.96e-09 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDHHC7 | insertion | Nonsense_Mutation | novel | c.976_977insATTAGCTCCGATGCTTTGCACTGAAGTTGCAAAAGATCTGTGCACT | p.Gly326AspfsTer2 | p.G326Dfs*2 | Q9NXF8 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZDHHC7 | insertion | Frame_Shift_Ins | novel | c.676_677insGAAGGGTGGCCCTCCTCTGCTCCTTGGAGAACAATGAATGTGCC | p.Ala226GlyfsTer17 | p.A226Gfs*17 | Q9NXF8 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZDHHC7 | SNV | Missense_Mutation | c.398N>A | p.Gly133Glu | p.G133E | Q9NXF8 | protein_coding | tolerated_low_confidence(0.08) | benign(0.05) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZDHHC7 | SNV | Missense_Mutation | rs139969155 | c.852N>G | p.Asn284Lys | p.N284K | Q9NXF8 | protein_coding | tolerated(0.08) | benign(0.232) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
ZDHHC7 | SNV | Missense_Mutation | rs751003316 | c.572N>A | p.Arg191Gln | p.R191Q | Q9NXF8 | protein_coding | deleterious(0) | benign(0.395) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZDHHC7 | SNV | Missense_Mutation | rs779916049 | c.448N>A | p.Ala150Thr | p.A150T | Q9NXF8 | protein_coding | deleterious(0.01) | possibly_damaging(0.576) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZDHHC7 | SNV | Missense_Mutation | novel | c.983G>A | p.Arg328Gln | p.R328Q | Q9NXF8 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZDHHC7 | SNV | Missense_Mutation | c.629N>T | p.Arg210Ile | p.R210I | Q9NXF8 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZDHHC7 | SNV | Missense_Mutation | c.784C>T | p.Leu262Phe | p.L262F | Q9NXF8 | protein_coding | tolerated(1) | benign(0.005) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZDHHC7 | SNV | Missense_Mutation | rs766777560 | c.538N>A | p.Ala180Thr | p.A180T | Q9NXF8 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55625 | ZDHHC7 | NA | methylphenidate | METHYLPHENIDATE | 29382897 |
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