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Gene: UQCC2 |
Gene summary for UQCC2 |
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Gene information | Species | Human | Gene symbol | UQCC2 | Gene ID | 84300 |
Gene name | ubiquinol-cytochrome c reductase complex assembly factor 2 | |
Gene Alias | C6orf125 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0002082 | UniProtAcc | Q9BRT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84300 | UQCC2 | P4T-E | Human | Esophagus | ESCC | 5.52e-74 | 1.89e+00 | 0.1323 |
84300 | UQCC2 | P5T-E | Human | Esophagus | ESCC | 5.84e-79 | 1.55e+00 | 0.1327 |
84300 | UQCC2 | P8T-E | Human | Esophagus | ESCC | 3.27e-36 | 8.46e-01 | 0.0889 |
84300 | UQCC2 | P9T-E | Human | Esophagus | ESCC | 7.24e-49 | 1.26e+00 | 0.1131 |
84300 | UQCC2 | P10T-E | Human | Esophagus | ESCC | 2.52e-41 | 8.79e-01 | 0.116 |
84300 | UQCC2 | P11T-E | Human | Esophagus | ESCC | 2.58e-31 | 1.13e+00 | 0.1426 |
84300 | UQCC2 | P12T-E | Human | Esophagus | ESCC | 1.19e-57 | 1.06e+00 | 0.1122 |
84300 | UQCC2 | P15T-E | Human | Esophagus | ESCC | 3.45e-41 | 9.08e-01 | 0.1149 |
84300 | UQCC2 | P16T-E | Human | Esophagus | ESCC | 6.49e-36 | 8.41e-01 | 0.1153 |
84300 | UQCC2 | P17T-E | Human | Esophagus | ESCC | 4.15e-45 | 2.13e+00 | 0.1278 |
84300 | UQCC2 | P19T-E | Human | Esophagus | ESCC | 1.28e-17 | 1.62e+00 | 0.1662 |
84300 | UQCC2 | P20T-E | Human | Esophagus | ESCC | 5.46e-38 | 8.59e-01 | 0.1124 |
84300 | UQCC2 | P21T-E | Human | Esophagus | ESCC | 3.05e-67 | 1.34e+00 | 0.1617 |
84300 | UQCC2 | P22T-E | Human | Esophagus | ESCC | 2.23e-108 | 1.96e+00 | 0.1236 |
84300 | UQCC2 | P23T-E | Human | Esophagus | ESCC | 3.30e-64 | 1.53e+00 | 0.108 |
84300 | UQCC2 | P24T-E | Human | Esophagus | ESCC | 1.98e-44 | 1.06e+00 | 0.1287 |
84300 | UQCC2 | P26T-E | Human | Esophagus | ESCC | 1.69e-26 | 8.17e-01 | 0.1276 |
84300 | UQCC2 | P27T-E | Human | Esophagus | ESCC | 1.53e-57 | 1.15e+00 | 0.1055 |
84300 | UQCC2 | P28T-E | Human | Esophagus | ESCC | 1.04e-63 | 1.27e+00 | 0.1149 |
84300 | UQCC2 | P30T-E | Human | Esophagus | ESCC | 2.43e-46 | 1.46e+00 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:00061199 | Breast | Precancer | oxidative phosphorylation | 53/1080 | 141/18723 | 1.15e-29 | 2.04e-26 | 53 |
GO:00090608 | Breast | Precancer | aerobic respiration | 58/1080 | 189/18723 | 5.69e-27 | 7.62e-24 | 58 |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00453338 | Breast | Precancer | cellular respiration | 59/1080 | 230/18723 | 5.97e-23 | 5.32e-20 | 59 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00331088 | Breast | Precancer | mitochondrial respiratory chain complex assembly | 24/1080 | 93/18723 | 3.39e-10 | 3.16e-08 | 24 |
GO:00434677 | Breast | Precancer | regulation of generation of precursor metabolites and energy | 22/1080 | 130/18723 | 4.95e-06 | 1.51e-04 | 22 |
GO:19035789 | Breast | Precancer | regulation of ATP metabolic process | 15/1080 | 87/18723 | 1.24e-04 | 2.21e-03 | 15 |
GO:0035914 | Breast | Precancer | skeletal muscle cell differentiation | 11/1080 | 67/18723 | 1.47e-03 | 1.52e-02 | 11 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:19037155 | Breast | Precancer | regulation of aerobic respiration | 7/1080 | 33/18723 | 2.37e-03 | 2.19e-02 | 7 |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00900875 | Breast | Precancer | regulation of peptide transport | 22/1080 | 202/18723 | 3.14e-03 | 2.65e-02 | 22 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00300736 | Breast | Precancer | insulin secretion | 21/1080 | 195/18723 | 4.38e-03 | 3.42e-02 | 21 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UQCC2 | SNV | Missense_Mutation | c.103G>T | p.Val35Leu | p.V35L | Q9BRT2 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-A2-A25D-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
UQCC2 | SNV | Missense_Mutation | rs531733294 | c.182N>T | p.Ala61Val | p.A61V | Q9BRT2 | protein_coding | tolerated(0.37) | benign(0.104) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UQCC2 | SNV | Missense_Mutation | c.221N>A | p.Arg74His | p.R74H | Q9BRT2 | protein_coding | tolerated(0.05) | benign(0.061) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UQCC2 | SNV | Missense_Mutation | novel | c.200N>G | p.Tyr67Cys | p.Y67C | Q9BRT2 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
UQCC2 | SNV | Missense_Mutation | novel | c.173N>G | p.Glu58Gly | p.E58G | Q9BRT2 | protein_coding | deleterious(0.01) | benign(0.053) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UQCC2 | SNV | Missense_Mutation | c.199N>G | p.Tyr67Asp | p.Y67D | Q9BRT2 | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UQCC2 | SNV | Missense_Mutation | novel | c.232A>G | p.Thr78Ala | p.T78A | Q9BRT2 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
UQCC2 | SNV | Missense_Mutation | c.60N>C | p.Glu20Asp | p.E20D | Q9BRT2 | protein_coding | tolerated(0.24) | benign(0.275) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
UQCC2 | SNV | Missense_Mutation | novel | c.255G>T | p.Leu85Phe | p.L85F | Q9BRT2 | protein_coding | deleterious(0.04) | benign(0.203) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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