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Gene: TXNIP |
Gene summary for TXNIP |
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Gene information | Species | Human | Gene symbol | TXNIP | Gene ID | 10628 |
Gene name | thioredoxin interacting protein | |
Gene Alias | ARRDC6 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H3M7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10628 | TXNIP | A015-C-006 | Human | Colorectum | FAP | 6.47e-17 | -4.75e-01 | -0.0994 |
10628 | TXNIP | A015-C-106 | Human | Colorectum | FAP | 8.25e-05 | -2.89e-01 | -0.0511 |
10628 | TXNIP | A002-C-114 | Human | Colorectum | FAP | 6.75e-24 | -6.20e-01 | -0.1561 |
10628 | TXNIP | A015-C-104 | Human | Colorectum | FAP | 4.69e-16 | -3.84e-01 | -0.1899 |
10628 | TXNIP | A001-C-014 | Human | Colorectum | FAP | 6.18e-11 | -3.02e-01 | 0.0135 |
10628 | TXNIP | A002-C-016 | Human | Colorectum | FAP | 7.66e-17 | -4.96e-01 | 0.0521 |
10628 | TXNIP | A015-C-002 | Human | Colorectum | FAP | 1.11e-14 | -5.63e-01 | -0.0763 |
10628 | TXNIP | A001-C-007 | Human | Colorectum | CRC | 1.23e-07 | -5.57e-01 | 0.1899 |
10628 | TXNIP | A001-C-203 | Human | Colorectum | FAP | 9.55e-04 | -2.76e-01 | -0.0481 |
10628 | TXNIP | A002-C-116 | Human | Colorectum | FAP | 1.29e-32 | -6.40e-01 | -0.0452 |
10628 | TXNIP | A014-C-008 | Human | Colorectum | FAP | 8.88e-17 | -4.98e-01 | -0.191 |
10628 | TXNIP | A018-E-020 | Human | Colorectum | FAP | 1.57e-18 | -4.02e-01 | -0.2034 |
10628 | TXNIP | F034 | Human | Colorectum | FAP | 2.19e-30 | -7.19e-01 | -0.0665 |
10628 | TXNIP | CRC-1-8810 | Human | Colorectum | CRC | 5.72e-18 | -5.85e-01 | 0.6257 |
10628 | TXNIP | CRC-3-11773 | Human | Colorectum | CRC | 1.63e-15 | -5.87e-01 | 0.2564 |
10628 | TXNIP | AEH-subject1 | Human | Endometrium | AEH | 6.60e-31 | -7.14e-01 | -0.3059 |
10628 | TXNIP | AEH-subject2 | Human | Endometrium | AEH | 1.22e-33 | -8.00e-01 | -0.2525 |
10628 | TXNIP | AEH-subject3 | Human | Endometrium | AEH | 3.71e-28 | -6.93e-01 | -0.2576 |
10628 | TXNIP | AEH-subject4 | Human | Endometrium | AEH | 2.36e-13 | -5.39e-01 | -0.2657 |
10628 | TXNIP | AEH-subject5 | Human | Endometrium | AEH | 5.17e-38 | -7.59e-01 | -0.2953 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00425429 | Breast | Precancer | response to hydrogen peroxide | 26/1080 | 146/18723 | 2.52e-07 | 1.26e-05 | 26 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00342849 | Breast | Precancer | response to monosaccharide | 29/1080 | 225/18723 | 4.19e-05 | 9.00e-04 | 29 |
GO:00097439 | Breast | Precancer | response to carbohydrate | 31/1080 | 253/18723 | 6.15e-05 | 1.25e-03 | 31 |
GO:00097469 | Breast | Precancer | response to hexose | 27/1080 | 219/18723 | 1.61e-04 | 2.69e-03 | 27 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:00712167 | Breast | Precancer | cellular response to biotic stimulus | 28/1080 | 246/18723 | 4.67e-04 | 6.14e-03 | 28 |
GO:00323555 | Breast | Precancer | response to estradiol | 19/1080 | 141/18723 | 4.81e-04 | 6.31e-03 | 19 |
GO:00097498 | Breast | Precancer | response to glucose | 25/1080 | 212/18723 | 5.46e-04 | 7.00e-03 | 25 |
GO:00725948 | Breast | Precancer | establishment of protein localization to organelle | 41/1080 | 422/18723 | 7.75e-04 | 9.20e-03 | 41 |
GO:00099136 | Breast | Precancer | epidermal cell differentiation | 23/1080 | 202/18723 | 1.43e-03 | 1.50e-02 | 23 |
GO:19016549 | Breast | Precancer | response to ketone | 22/1080 | 194/18723 | 1.89e-03 | 1.84e-02 | 22 |
GO:00515925 | Breast | Precancer | response to calcium ion | 18/1080 | 149/18723 | 2.37e-03 | 2.19e-02 | 18 |
GO:00302163 | Breast | Precancer | keratinocyte differentiation | 17/1080 | 139/18723 | 2.71e-03 | 2.39e-02 | 17 |
GO:00096126 | Breast | Precancer | response to mechanical stimulus | 23/1080 | 216/18723 | 3.41e-03 | 2.85e-02 | 23 |
GO:0002347 | Breast | Precancer | response to tumor cell | 7/1080 | 39/18723 | 6.32e-03 | 4.43e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046213 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa0462112 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa046219 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462114 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0462131 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNIP | SNV | Missense_Mutation | c.511N>G | p.Met171Val | p.M171V | Q9H3M7 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
TXNIP | SNV | Missense_Mutation | c.392N>A | p.Arg131His | p.R131H | Q9H3M7 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TXNIP | insertion | In_Frame_Ins | novel | c.267_268insCAG | p.Val89_Ile90insGln | p.V89_I90insQ | Q9H3M7 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TXNIP | insertion | Frame_Shift_Ins | novel | c.265_266insAGGTTGCAGTGAGCCCAGAC | p.Val89GlufsTer8 | p.V89Efs*8 | Q9H3M7 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TXNIP | deletion | Frame_Shift_Del | novel | c.705_708delNNNN | p.Val237GlufsTer40 | p.V237Efs*40 | Q9H3M7 | protein_coding | TCGA-DS-A3LQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
TXNIP | SNV | Missense_Mutation | c.26N>A | p.Ser9Tyr | p.S9Y | Q9H3M7 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TXNIP | SNV | Missense_Mutation | c.561N>C | p.Lys187Asn | p.K187N | Q9H3M7 | protein_coding | deleterious(0) | possibly_damaging(0.543) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TXNIP | SNV | Missense_Mutation | c.1141G>A | p.Val381Met | p.V381M | Q9H3M7 | protein_coding | deleterious(0.02) | benign(0.017) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TXNIP | SNV | Missense_Mutation | c.26C>A | p.Ser9Tyr | p.S9Y | Q9H3M7 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TXNIP | insertion | In_Frame_Ins | novel | c.989-1_989insTAAAGATGA | p.Ala330delinsValLysMetThr | p.A330delinsVKMT | Q9H3M7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10628 | TXNIP | TRANSCRIPTION FACTOR | FAS-LIGAND | 12706526 |
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