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Gene: TXLNA |
Gene summary for TXLNA |
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Gene information | Species | Human | Gene symbol | TXLNA | Gene ID | 200081 |
Gene name | taxilin alpha | |
Gene Alias | IL14 | |
Cytomap | 1p35.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P40222 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200081 | TXLNA | HCC2_Meng | Human | Liver | HCC | 1.25e-08 | -7.06e-04 | 0.0107 |
200081 | TXLNA | HCC1 | Human | Liver | HCC | 1.49e-06 | 3.53e+00 | 0.5336 |
200081 | TXLNA | HCC2 | Human | Liver | HCC | 3.73e-25 | 4.33e+00 | 0.5341 |
200081 | TXLNA | Pt13.b | Human | Liver | HCC | 1.11e-05 | 7.29e-02 | 0.0251 |
200081 | TXLNA | Pt14.b | Human | Liver | HCC | 1.38e-03 | 1.87e-01 | 0.018 |
200081 | TXLNA | S014 | Human | Liver | HCC | 1.41e-17 | 7.56e-01 | 0.2254 |
200081 | TXLNA | S015 | Human | Liver | HCC | 3.46e-12 | 6.53e-01 | 0.2375 |
200081 | TXLNA | S016 | Human | Liver | HCC | 8.75e-17 | 6.64e-01 | 0.2243 |
200081 | TXLNA | S027 | Human | Liver | HCC | 4.55e-25 | 1.53e+00 | 0.2446 |
200081 | TXLNA | S028 | Human | Liver | HCC | 7.70e-34 | 1.34e+00 | 0.2503 |
200081 | TXLNA | S029 | Human | Liver | HCC | 2.01e-32 | 1.56e+00 | 0.2581 |
200081 | TXLNA | C04 | Human | Oral cavity | OSCC | 5.46e-09 | 5.27e-01 | 0.2633 |
200081 | TXLNA | C21 | Human | Oral cavity | OSCC | 1.10e-15 | 5.34e-01 | 0.2678 |
200081 | TXLNA | C30 | Human | Oral cavity | OSCC | 4.89e-30 | 1.20e+00 | 0.3055 |
200081 | TXLNA | C43 | Human | Oral cavity | OSCC | 1.11e-02 | 1.65e-01 | 0.1704 |
200081 | TXLNA | C46 | Human | Oral cavity | OSCC | 1.06e-11 | 3.98e-01 | 0.1673 |
200081 | TXLNA | C51 | Human | Oral cavity | OSCC | 9.05e-06 | 3.86e-01 | 0.2674 |
200081 | TXLNA | C06 | Human | Oral cavity | OSCC | 1.47e-03 | 7.74e-01 | 0.2699 |
200081 | TXLNA | C07 | Human | Oral cavity | OSCC | 7.06e-04 | 8.77e-01 | 0.2491 |
200081 | TXLNA | C08 | Human | Oral cavity | OSCC | 1.42e-02 | 1.60e-01 | 0.1919 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXLNA | SNV | Missense_Mutation | novel | c.651N>C | p.Gln217His | p.Q217H | P40222 | protein_coding | deleterious(0.02) | possibly_damaging(0.823) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
TXLNA | SNV | Missense_Mutation | rs746949166 | c.400N>A | p.Glu134Lys | p.E134K | P40222 | protein_coding | tolerated(0.07) | probably_damaging(0.985) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
TXLNA | SNV | Missense_Mutation | c.995T>A | p.Leu332Gln | p.L332Q | P40222 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TXLNA | insertion | Frame_Shift_Ins | novel | c.1502_1503insACCA | p.Glu502ProfsTer2 | p.E502Pfs*2 | P40222 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TXLNA | insertion | Frame_Shift_Ins | novel | c.1504_1505insCCTGGCTAATTTTTTCTTTCTTTTTTTTTTGTATTTTT | p.Glu502AlafsTer79 | p.E502Afs*79 | P40222 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TXLNA | insertion | Nonsense_Mutation | novel | c.250_251insCTTTTCCGTAAAATGG | p.Ser84ThrfsTer4 | p.S84Tfs*4 | P40222 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TXLNA | deletion | Frame_Shift_Del | novel | c.355delA | p.Arg119GlyfsTer10 | p.R119Gfs*10 | P40222 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TXLNA | SNV | Missense_Mutation | rs780644587 | c.205C>T | p.Arg69Cys | p.R69C | P40222 | protein_coding | tolerated(0.21) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TXLNA | SNV | Missense_Mutation | rs776440607 | c.809G>A | p.Arg270His | p.R270H | P40222 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TXLNA | SNV | Missense_Mutation | novel | c.1378C>A | p.Leu460Met | p.L460M | P40222 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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