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Gene: TRPT1 |
Gene summary for TRPT1 |
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Gene information | Species | Human | Gene symbol | TRPT1 | Gene ID | 83707 |
Gene name | tRNA phosphotransferase 1 | |
Gene Alias | TRPT1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000394 | UniProtAcc | Q86TN4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83707 | TRPT1 | P107T-E | Human | Esophagus | ESCC | 1.22e-47 | 9.80e-01 | 0.171 |
83707 | TRPT1 | P126T-E | Human | Esophagus | ESCC | 1.85e-05 | 8.41e-01 | 0.1125 |
83707 | TRPT1 | P127T-E | Human | Esophagus | ESCC | 1.67e-15 | 3.20e-01 | 0.0826 |
83707 | TRPT1 | P128T-E | Human | Esophagus | ESCC | 1.94e-51 | 1.50e+00 | 0.1241 |
83707 | TRPT1 | P130T-E | Human | Esophagus | ESCC | 2.79e-44 | 8.86e-01 | 0.1676 |
83707 | TRPT1 | HCC1_Meng | Human | Liver | HCC | 2.74e-52 | 6.19e-02 | 0.0246 |
83707 | TRPT1 | HCC2_Meng | Human | Liver | HCC | 1.39e-17 | 4.35e-02 | 0.0107 |
83707 | TRPT1 | cirrhotic3 | Human | Liver | Cirrhotic | 6.28e-04 | 7.58e-02 | 0.0215 |
83707 | TRPT1 | HCC2 | Human | Liver | HCC | 5.76e-05 | 3.03e+00 | 0.5341 |
83707 | TRPT1 | Pt13.b | Human | Liver | HCC | 2.22e-06 | 6.62e-02 | 0.0251 |
83707 | TRPT1 | S014 | Human | Liver | HCC | 4.52e-25 | 8.42e-01 | 0.2254 |
83707 | TRPT1 | S015 | Human | Liver | HCC | 2.79e-21 | 8.80e-01 | 0.2375 |
83707 | TRPT1 | S016 | Human | Liver | HCC | 2.46e-28 | 9.17e-01 | 0.2243 |
83707 | TRPT1 | S027 | Human | Liver | HCC | 4.43e-11 | 9.31e-01 | 0.2446 |
83707 | TRPT1 | S028 | Human | Liver | HCC | 3.54e-19 | 8.41e-01 | 0.2503 |
83707 | TRPT1 | S029 | Human | Liver | HCC | 1.89e-21 | 1.09e+00 | 0.2581 |
83707 | TRPT1 | C04 | Human | Oral cavity | OSCC | 1.11e-08 | 6.05e-01 | 0.2633 |
83707 | TRPT1 | C21 | Human | Oral cavity | OSCC | 5.40e-66 | 1.84e+00 | 0.2678 |
83707 | TRPT1 | C30 | Human | Oral cavity | OSCC | 5.29e-40 | 1.60e+00 | 0.3055 |
83707 | TRPT1 | C38 | Human | Oral cavity | OSCC | 3.27e-04 | 4.65e-01 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:00003942 | Esophagus | HGIN | RNA splicing, via endonucleolytic cleavage and ligation | 6/2587 | 11/18723 | 1.71e-03 | 1.86e-02 | 6 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPT1 | insertion | Nonsense_Mutation | novel | c.458_459insTCAGCCTCCCGAGTAGCTGGGATTATAG | p.His154GlnfsTer5 | p.H154Qfs*5 | Q86TN4 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TRPT1 | SNV | Missense_Mutation | rs755471912 | c.712N>A | p.Glu238Lys | p.E238K | Q86TN4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.054) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
TRPT1 | SNV | Missense_Mutation | c.232N>A | p.Val78Met | p.V78M | Q86TN4 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRPT1 | SNV | Missense_Mutation | rs778666111 | c.550C>G | p.Pro184Ala | p.P184A | Q86TN4 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
TRPT1 | SNV | Missense_Mutation | novel | c.106T>C | p.Ser36Pro | p.S36P | Q86TN4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRPT1 | SNV | Missense_Mutation | rs760406732 | c.176N>A | p.Gly59Asp | p.G59D | Q86TN4 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRPT1 | SNV | Missense_Mutation | c.308A>T | p.Asn103Ile | p.N103I | Q86TN4 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRPT1 | SNV | Missense_Mutation | c.401N>T | p.Thr134Ile | p.T134I | Q86TN4 | protein_coding | deleterious(0.03) | probably_damaging(0.914) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
TRPT1 | insertion | Frame_Shift_Ins | novel | c.127_128insG | p.Ala43GlyfsTer11 | p.A43Gfs*11 | Q86TN4 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
TRPT1 | SNV | Missense_Mutation | novel | c.463N>C | p.Ile155Leu | p.I155L | Q86TN4 | protein_coding | deleterious(0.05) | benign(0.35) | TCGA-2V-A95S-01 | Liver | liver hepatocellular carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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