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Gene: TOX4 |
Gene summary for TOX4 |
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Gene information | Species | Human | Gene symbol | TOX4 | Gene ID | 9878 |
Gene name | TOX high mobility group box family member 4 | |
Gene Alias | C14orf92 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O94842 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9878 | TOX4 | P94T-E | Human | Esophagus | ESCC | 1.66e-02 | 5.47e-01 | 0.0879 |
9878 | TOX4 | P104T-E | Human | Esophagus | ESCC | 1.62e-09 | 3.45e-01 | 0.0931 |
9878 | TOX4 | P107T-E | Human | Esophagus | ESCC | 5.36e-49 | 1.24e+00 | 0.171 |
9878 | TOX4 | P126T-E | Human | Esophagus | ESCC | 3.52e-04 | 9.59e-01 | 0.1125 |
9878 | TOX4 | P127T-E | Human | Esophagus | ESCC | 3.35e-28 | 4.67e-01 | 0.0826 |
9878 | TOX4 | P128T-E | Human | Esophagus | ESCC | 3.35e-42 | 1.41e+00 | 0.1241 |
9878 | TOX4 | P130T-E | Human | Esophagus | ESCC | 2.79e-69 | 1.36e+00 | 0.1676 |
9878 | TOX4 | S43 | Human | Liver | Cirrhotic | 4.59e-03 | -9.60e-02 | -0.0187 |
9878 | TOX4 | HCC1_Meng | Human | Liver | HCC | 6.96e-65 | 6.90e-02 | 0.0246 |
9878 | TOX4 | HCC2_Meng | Human | Liver | HCC | 1.57e-25 | 1.72e-01 | 0.0107 |
9878 | TOX4 | cirrhotic1 | Human | Liver | Cirrhotic | 6.85e-03 | 1.65e-01 | 0.0202 |
9878 | TOX4 | cirrhotic3 | Human | Liver | Cirrhotic | 4.33e-02 | 2.10e-02 | 0.0215 |
9878 | TOX4 | HCC1 | Human | Liver | HCC | 7.62e-05 | 3.92e+00 | 0.5336 |
9878 | TOX4 | HCC2 | Human | Liver | HCC | 3.82e-10 | 4.04e+00 | 0.5341 |
9878 | TOX4 | Pt13.b | Human | Liver | HCC | 8.71e-14 | 2.18e-01 | 0.0251 |
9878 | TOX4 | Pt14.b | Human | Liver | HCC | 3.76e-08 | 3.62e-01 | 0.018 |
9878 | TOX4 | S014 | Human | Liver | HCC | 5.86e-27 | 9.06e-01 | 0.2254 |
9878 | TOX4 | S015 | Human | Liver | HCC | 1.79e-17 | 1.05e+00 | 0.2375 |
9878 | TOX4 | S016 | Human | Liver | HCC | 9.73e-25 | 9.24e-01 | 0.2243 |
9878 | TOX4 | S027 | Human | Liver | HCC | 1.73e-04 | 6.95e-01 | 0.2446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOX4 | SNV | Missense_Mutation | novel | c.703N>T | p.Arg235Cys | p.R235C | O94842 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | novel | c.1325N>T | p.Arg442Leu | p.R442L | O94842 | protein_coding | tolerated(0.5) | benign(0.4) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | c.179N>T | p.Asp60Val | p.D60V | O94842 | protein_coding | deleterious(0.02) | possibly_damaging(0.767) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
TOX4 | SNV | Missense_Mutation | c.1849G>A | p.Val617Met | p.V617M | O94842 | protein_coding | tolerated(0.24) | probably_damaging(0.969) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TOX4 | SNV | Missense_Mutation | c.1402C>G | p.Pro468Ala | p.P468A | O94842 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
TOX4 | SNV | Missense_Mutation | rs775810291 | c.962N>A | p.Thr321Asn | p.T321N | O94842 | protein_coding | tolerated(0.52) | benign(0.133) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
TOX4 | insertion | Nonsense_Mutation | novel | c.804_805insTTTAGTGTTTAATT | p.Lys269PhefsTer4 | p.K269Ffs*4 | O94842 | protein_coding | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TOX4 | deletion | Frame_Shift_Del | c.1665_1672delNNNNNNNN | p.Val556GlyfsTer20 | p.V556Gfs*20 | O94842 | protein_coding | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |||
TOX4 | SNV | Missense_Mutation | novel | c.1261C>T | p.Arg421Trp | p.R421W | O94842 | protein_coding | tolerated(0.14) | possibly_damaging(0.853) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | c.1639N>A | p.Glu547Lys | p.E547K | O94842 | protein_coding | deleterious(0.03) | benign(0.114) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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