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Gene: TOR1AIP2 |
Gene summary for TOR1AIP2 |
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Gene information | Species | Human | Gene symbol | TOR1AIP2 | Gene ID | 163590 |
Gene name | torsin 1A interacting protein 2 | |
Gene Alias | IFRG15 | |
Cytomap | 1q25.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A0A024R957 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163590 | TOR1AIP2 | P107T-E | Human | Esophagus | ESCC | 1.65e-28 | 7.00e-01 | 0.171 |
163590 | TOR1AIP2 | P126T-E | Human | Esophagus | ESCC | 1.15e-06 | 8.28e-01 | 0.1125 |
163590 | TOR1AIP2 | P127T-E | Human | Esophagus | ESCC | 2.48e-25 | 4.35e-01 | 0.0826 |
163590 | TOR1AIP2 | P128T-E | Human | Esophagus | ESCC | 2.52e-34 | 1.08e+00 | 0.1241 |
163590 | TOR1AIP2 | P130T-E | Human | Esophagus | ESCC | 7.29e-52 | 1.22e+00 | 0.1676 |
163590 | TOR1AIP2 | NAFLD1 | Human | Liver | NAFLD | 1.69e-06 | 5.33e-01 | -0.04 |
163590 | TOR1AIP2 | S42 | Human | Liver | HCC | 3.51e-02 | -4.51e-01 | -0.0103 |
163590 | TOR1AIP2 | S43 | Human | Liver | Cirrhotic | 3.73e-25 | -4.05e-01 | -0.0187 |
163590 | TOR1AIP2 | S44 | Human | Liver | HCC | 9.52e-15 | 7.55e-01 | -0.0083 |
163590 | TOR1AIP2 | HCC1_Meng | Human | Liver | HCC | 4.17e-89 | -2.56e-01 | 0.0246 |
163590 | TOR1AIP2 | HCC2_Meng | Human | Liver | HCC | 6.94e-44 | -3.18e-01 | 0.0107 |
163590 | TOR1AIP2 | cirrhotic1 | Human | Liver | Cirrhotic | 2.39e-08 | 7.40e-02 | 0.0202 |
163590 | TOR1AIP2 | cirrhotic2 | Human | Liver | Cirrhotic | 7.59e-13 | -3.51e-02 | 0.0201 |
163590 | TOR1AIP2 | cirrhotic3 | Human | Liver | Cirrhotic | 1.20e-09 | -1.81e-01 | 0.0215 |
163590 | TOR1AIP2 | p6 | Human | Liver | Cyst | 3.66e-04 | -7.06e-01 | -0.0218 |
163590 | TOR1AIP2 | HCC1 | Human | Liver | HCC | 2.19e-17 | 4.49e+00 | 0.5336 |
163590 | TOR1AIP2 | HCC2 | Human | Liver | HCC | 1.65e-23 | 5.22e+00 | 0.5341 |
163590 | TOR1AIP2 | Pt13.a | Human | Liver | HCC | 1.21e-04 | -3.20e-01 | 0.021 |
163590 | TOR1AIP2 | Pt13.b | Human | Liver | HCC | 2.02e-15 | -6.32e-02 | 0.0251 |
163590 | TOR1AIP2 | Pt13.c | Human | Liver | HCC | 3.01e-05 | -5.37e-01 | 0.0076 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:000702914 | Esophagus | ESCC | endoplasmic reticulum organization | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:00434627 | Esophagus | ESCC | regulation of ATPase activity | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
GO:00345046 | Liver | NAFLD | protein localization to nucleus | 45/1882 | 290/18723 | 2.16e-03 | 2.10e-02 | 45 |
GO:003450411 | Liver | Cirrhotic | protein localization to nucleus | 113/4634 | 290/18723 | 5.00e-08 | 1.58e-06 | 113 |
GO:00070292 | Liver | Cirrhotic | endoplasmic reticulum organization | 42/4634 | 87/18723 | 1.67e-06 | 3.22e-05 | 42 |
GO:00327812 | Liver | Cirrhotic | positive regulation of ATPase activity | 16/4634 | 27/18723 | 1.41e-04 | 1.36e-03 | 16 |
GO:00434623 | Liver | Cirrhotic | regulation of ATPase activity | 21/4634 | 46/18723 | 1.61e-03 | 1.04e-02 | 21 |
GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
GO:000702911 | Liver | HCC | endoplasmic reticulum organization | 64/7958 | 87/18723 | 3.92e-09 | 1.04e-07 | 64 |
GO:00327811 | Liver | HCC | positive regulation of ATPase activity | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:004346211 | Liver | HCC | regulation of ATPase activity | 29/7958 | 46/18723 | 3.95e-03 | 1.74e-02 | 29 |
GO:003450431 | Liver | Cyst | protein localization to nucleus | 17/496 | 290/18723 | 1.97e-03 | 4.15e-02 | 17 |
GO:003450415 | Oral cavity | OSCC | protein localization to nucleus | 193/7305 | 290/18723 | 1.22e-21 | 2.35e-19 | 193 |
GO:00070294 | Oral cavity | OSCC | endoplasmic reticulum organization | 58/7305 | 87/18723 | 1.59e-07 | 2.61e-06 | 58 |
GO:00327815 | Oral cavity | OSCC | positive regulation of ATPase activity | 18/7305 | 27/18723 | 3.34e-03 | 1.42e-02 | 18 |
GO:00434626 | Oral cavity | OSCC | regulation of ATPase activity | 27/7305 | 46/18723 | 5.33e-03 | 2.07e-02 | 27 |
GO:003450416 | Oral cavity | LP | protein localization to nucleus | 133/4623 | 290/18723 | 2.41e-15 | 3.35e-13 | 133 |
GO:000702913 | Oral cavity | LP | endoplasmic reticulum organization | 41/4623 | 87/18723 | 4.49e-06 | 9.16e-05 | 41 |
GO:003278113 | Oral cavity | LP | positive regulation of ATPase activity | 13/4623 | 27/18723 | 6.92e-03 | 3.96e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOR1AIP2 | SNV | Missense_Mutation | c.648N>T | p.Trp216Cys | p.W216C | Q8NFQ8 | protein_coding | deleterious(0.03) | benign(0.012) | TCGA-AR-A1AY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Doxorubicin | SD | |
TOR1AIP2 | SNV | Missense_Mutation | novel | c.724N>G | p.Pro242Ala | p.P242A | Q8NFQ8 | protein_coding | deleterious(0.02) | benign(0.192) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOR1AIP2 | SNV | Missense_Mutation | c.314N>T | p.Ser105Leu | p.S105L | Q8NFQ8 | protein_coding | tolerated_low_confidence(0.05) | benign(0.018) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TOR1AIP2 | SNV | Missense_Mutation | novel | c.667N>G | p.Leu223Val | p.L223V | Q8NFQ8 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-RA-A741-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TOR1AIP2 | SNV | Missense_Mutation | c.1091N>A | p.Val364Glu | p.V364E | Q8NFQ8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TOR1AIP2 | SNV | Missense_Mutation | rs772272447 | c.469G>C | p.Asp157His | p.D157H | Q8NFQ8 | protein_coding | deleterious(0) | possibly_damaging(0.726) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
TOR1AIP2 | SNV | Missense_Mutation | novel | c.334C>T | p.Pro112Ser | p.P112S | Q8NFQ8 | protein_coding | tolerated_low_confidence(0.29) | benign(0.033) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TOR1AIP2 | SNV | Missense_Mutation | rs200952880 | c.832N>T | p.Arg278Trp | p.R278W | Q8NFQ8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
TOR1AIP2 | SNV | Missense_Mutation | c.799C>T | p.Pro267Ser | p.P267S | Q8NFQ8 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TOR1AIP2 | SNV | Missense_Mutation | c.584N>C | p.Lys195Thr | p.K195T | Q8NFQ8 | protein_coding | tolerated(0.63) | benign(0.012) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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