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Gene: TOMM5 |
Gene summary for TOMM5 |
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Gene information | Species | Human | Gene symbol | TOMM5 | Gene ID | 401505 |
Gene name | translocase of outer mitochondrial membrane 5 | |
Gene Alias | C9orf105 | |
Cytomap | 9p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q8N4H5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401505 | TOMM5 | P38T-E | Human | Esophagus | ESCC | 9.53e-35 | 1.31e+00 | 0.127 |
401505 | TOMM5 | P39T-E | Human | Esophagus | ESCC | 6.03e-56 | 9.90e-01 | 0.0894 |
401505 | TOMM5 | P40T-E | Human | Esophagus | ESCC | 5.70e-40 | 1.25e+00 | 0.109 |
401505 | TOMM5 | P42T-E | Human | Esophagus | ESCC | 5.30e-69 | 1.49e+00 | 0.1175 |
401505 | TOMM5 | P44T-E | Human | Esophagus | ESCC | 5.86e-36 | 9.65e-01 | 0.1096 |
401505 | TOMM5 | P47T-E | Human | Esophagus | ESCC | 4.99e-71 | 1.14e+00 | 0.1067 |
401505 | TOMM5 | P48T-E | Human | Esophagus | ESCC | 5.12e-47 | 8.95e-01 | 0.0959 |
401505 | TOMM5 | P49T-E | Human | Esophagus | ESCC | 1.54e-30 | 2.75e+00 | 0.1768 |
401505 | TOMM5 | P52T-E | Human | Esophagus | ESCC | 3.09e-102 | 2.15e+00 | 0.1555 |
401505 | TOMM5 | P54T-E | Human | Esophagus | ESCC | 1.50e-58 | 1.13e+00 | 0.0975 |
401505 | TOMM5 | P56T-E | Human | Esophagus | ESCC | 1.99e-17 | 1.99e+00 | 0.1613 |
401505 | TOMM5 | P57T-E | Human | Esophagus | ESCC | 6.31e-57 | 8.76e-01 | 0.0926 |
401505 | TOMM5 | P61T-E | Human | Esophagus | ESCC | 4.84e-53 | 1.15e+00 | 0.099 |
401505 | TOMM5 | P62T-E | Human | Esophagus | ESCC | 1.24e-104 | 1.92e+00 | 0.1302 |
401505 | TOMM5 | P65T-E | Human | Esophagus | ESCC | 1.90e-48 | 9.11e-01 | 0.0978 |
401505 | TOMM5 | P74T-E | Human | Esophagus | ESCC | 1.00e-83 | 2.56e+00 | 0.1479 |
401505 | TOMM5 | P75T-E | Human | Esophagus | ESCC | 1.86e-150 | 3.06e+00 | 0.1125 |
401505 | TOMM5 | P76T-E | Human | Esophagus | ESCC | 2.79e-80 | 1.56e+00 | 0.1207 |
401505 | TOMM5 | P79T-E | Human | Esophagus | ESCC | 2.08e-94 | 1.72e+00 | 0.1154 |
401505 | TOMM5 | P80T-E | Human | Esophagus | ESCC | 2.39e-93 | 2.79e+00 | 0.155 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00705858 | Breast | Precancer | protein localization to mitochondrion | 21/1080 | 125/18723 | 9.07e-06 | 2.42e-04 | 21 |
GO:00726558 | Breast | Precancer | establishment of protein localization to mitochondrion | 20/1080 | 120/18723 | 1.66e-05 | 4.03e-04 | 20 |
GO:00066268 | Breast | Precancer | protein targeting to mitochondrion | 15/1080 | 100/18723 | 5.94e-04 | 7.48e-03 | 15 |
GO:00066059 | Breast | Precancer | protein targeting | 33/1080 | 314/18723 | 6.50e-04 | 7.99e-03 | 33 |
GO:00725948 | Breast | Precancer | establishment of protein localization to organelle | 41/1080 | 422/18723 | 7.75e-04 | 9.20e-03 | 41 |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:007058513 | Breast | IDC | protein localization to mitochondrion | 23/1434 | 125/18723 | 6.92e-05 | 1.40e-03 | 23 |
GO:007265513 | Breast | IDC | establishment of protein localization to mitochondrion | 22/1434 | 120/18723 | 1.04e-04 | 1.97e-03 | 22 |
GO:000660514 | Breast | IDC | protein targeting | 43/1434 | 314/18723 | 1.44e-04 | 2.53e-03 | 43 |
GO:007259413 | Breast | IDC | establishment of protein localization to organelle | 51/1434 | 422/18723 | 7.94e-04 | 9.55e-03 | 51 |
GO:000662613 | Breast | IDC | protein targeting to mitochondrion | 17/1434 | 100/18723 | 1.47e-03 | 1.50e-02 | 17 |
GO:000683923 | Breast | DCIS | mitochondrial transport | 51/1390 | 254/18723 | 5.04e-11 | 6.79e-09 | 51 |
GO:007058522 | Breast | DCIS | protein localization to mitochondrion | 23/1390 | 125/18723 | 4.28e-05 | 9.05e-04 | 23 |
GO:007265522 | Breast | DCIS | establishment of protein localization to mitochondrion | 22/1390 | 120/18723 | 6.60e-05 | 1.31e-03 | 22 |
GO:000660523 | Breast | DCIS | protein targeting | 43/1390 | 314/18723 | 7.17e-05 | 1.41e-03 | 43 |
GO:007259423 | Breast | DCIS | establishment of protein localization to organelle | 51/1390 | 422/18723 | 3.91e-04 | 5.40e-03 | 51 |
GO:000662622 | Breast | DCIS | protein targeting to mitochondrion | 17/1390 | 100/18723 | 1.05e-03 | 1.15e-02 | 17 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOMM5 | deletion | Frame_Shift_Del | novel | c.2delN | p.Met1? | p.M1? | Q8N4H5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TOMM5 | SNV | Missense_Mutation | c.246C>G | p.Cys82Trp | p.C82W | Q8N4H5 | protein_coding | tolerated_low_confidence(0.21) | benign(0.279) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOMM5 | SNV | Missense_Mutation | novel | c.202N>A | p.Gly68Ser | p.G68S | Q8N4H5 | protein_coding | tolerated_low_confidence(0.16) | benign(0.082) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOMM5 | SNV | Missense_Mutation | novel | c.263N>A | p.Gly88Asp | p.G88D | Q8N4H5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.876) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TOMM5 | SNV | Missense_Mutation | novel | c.196N>A | p.His66Asn | p.H66N | Q8N4H5 | protein_coding | tolerated_low_confidence(0.11) | benign(0.001) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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