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Gene: TMX1 |
Gene summary for TMX1 |
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Gene information | Species | Human | Gene symbol | TMX1 | Gene ID | 81542 |
Gene name | thioredoxin related transmembrane protein 1 | |
Gene Alias | PDIA11 | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q9H3N1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81542 | TMX1 | P107T-E | Human | Esophagus | ESCC | 3.90e-46 | 1.31e+00 | 0.171 |
81542 | TMX1 | P126T-E | Human | Esophagus | ESCC | 2.89e-11 | 1.07e+00 | 0.1125 |
81542 | TMX1 | P127T-E | Human | Esophagus | ESCC | 9.38e-18 | 3.34e-01 | 0.0826 |
81542 | TMX1 | P128T-E | Human | Esophagus | ESCC | 1.05e-37 | 1.18e+00 | 0.1241 |
81542 | TMX1 | P130T-E | Human | Esophagus | ESCC | 6.31e-65 | 1.58e+00 | 0.1676 |
81542 | TMX1 | S43 | Human | Liver | Cirrhotic | 2.25e-04 | -4.53e-02 | -0.0187 |
81542 | TMX1 | HCC1_Meng | Human | Liver | HCC | 1.64e-86 | 2.17e-01 | 0.0246 |
81542 | TMX1 | HCC2_Meng | Human | Liver | HCC | 2.68e-42 | 1.18e-01 | 0.0107 |
81542 | TMX1 | cirrhotic2 | Human | Liver | Cirrhotic | 6.81e-05 | 6.27e-02 | 0.0201 |
81542 | TMX1 | HCC1 | Human | Liver | HCC | 3.82e-03 | 3.73e+00 | 0.5336 |
81542 | TMX1 | HCC2 | Human | Liver | HCC | 2.65e-02 | 2.56e+00 | 0.5341 |
81542 | TMX1 | Pt13.b | Human | Liver | HCC | 7.74e-10 | 7.63e-02 | 0.0251 |
81542 | TMX1 | S014 | Human | Liver | HCC | 6.39e-16 | 8.13e-01 | 0.2254 |
81542 | TMX1 | S015 | Human | Liver | HCC | 8.33e-18 | 1.04e+00 | 0.2375 |
81542 | TMX1 | S016 | Human | Liver | HCC | 1.44e-22 | 8.84e-01 | 0.2243 |
81542 | TMX1 | S028 | Human | Liver | HCC | 1.31e-04 | 3.67e-01 | 0.2503 |
81542 | TMX1 | S029 | Human | Liver | HCC | 1.71e-10 | 5.72e-01 | 0.2581 |
81542 | TMX1 | C04 | Human | Oral cavity | OSCC | 4.90e-36 | 1.86e+00 | 0.2633 |
81542 | TMX1 | C21 | Human | Oral cavity | OSCC | 4.42e-55 | 1.97e+00 | 0.2678 |
81542 | TMX1 | C30 | Human | Oral cavity | OSCC | 1.31e-47 | 2.40e+00 | 0.3055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:003497620 | Oral cavity | OSCC | response to endoplasmic reticulum stress | 178/7305 | 256/18723 | 2.59e-23 | 6.06e-21 | 178 |
GO:0034976110 | Oral cavity | LP | response to endoplasmic reticulum stress | 133/4623 | 256/18723 | 3.84e-21 | 9.24e-19 | 133 |
GO:0034976112 | Skin | cSCC | response to endoplasmic reticulum stress | 128/4864 | 256/18723 | 1.16e-16 | 1.17e-14 | 128 |
GO:0034976113 | Thyroid | PTC | response to endoplasmic reticulum stress | 161/5968 | 256/18723 | 1.14e-24 | 3.27e-22 | 161 |
GO:003497633 | Thyroid | ATC | response to endoplasmic reticulum stress | 167/6293 | 256/18723 | 2.62e-25 | 1.03e-22 | 167 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMX1 | SNV | Missense_Mutation | novel | c.65N>T | p.Pro22Leu | p.P22L | Q9H3N1 | protein_coding | tolerated(0.27) | probably_damaging(0.942) | TCGA-A7-A3IY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TMX1 | SNV | Missense_Mutation | c.706G>A | p.Glu236Lys | p.E236K | Q9H3N1 | protein_coding | tolerated(0.19) | benign(0.227) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMX1 | SNV | Missense_Mutation | c.597N>A | p.Met199Ile | p.M199I | Q9H3N1 | protein_coding | tolerated(0.41) | benign(0.014) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMX1 | SNV | Missense_Mutation | rs777140042 | c.86N>A | p.Ser29Asn | p.S29N | Q9H3N1 | protein_coding | tolerated(0.23) | benign(0.03) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMX1 | SNV | Missense_Mutation | novel | c.257C>T | p.Thr86Ile | p.T86I | Q9H3N1 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMX1 | SNV | Missense_Mutation | rs775236782 | c.242N>T | p.Ala81Val | p.A81V | Q9H3N1 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
TMX1 | SNV | Missense_Mutation | rs369843771 | c.635G>A | p.Arg212His | p.R212H | Q9H3N1 | protein_coding | tolerated(0.89) | benign(0.001) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMX1 | SNV | Missense_Mutation | novel | c.500A>C | p.Asn167Thr | p.N167T | Q9H3N1 | protein_coding | tolerated(0.31) | benign(0.015) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMX1 | SNV | Missense_Mutation | novel | c.724G>A | p.Asp242Asn | p.D242N | Q9H3N1 | protein_coding | tolerated(0.3) | possibly_damaging(0.505) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMX1 | SNV | Missense_Mutation | novel | c.322N>T | p.Asp108Tyr | p.D108Y | Q9H3N1 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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