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Gene: TMEM241 |
Gene summary for TMEM241 |
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Gene information | Species | Human | Gene symbol | TMEM241 | Gene ID | 85019 |
Gene name | transmembrane protein 241 | |
Gene Alias | C18orf45 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4DH40 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85019 | TMEM241 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 8.37e-05 | 6.09e-01 | -0.0876 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM241 | SNV | Missense_Mutation | c.853N>C | p.Glu285Gln | p.E285Q | Q24JQ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM241 | SNV | Missense_Mutation | novel | c.227N>T | p.Ser76Leu | p.S76L | Q24JQ0 | protein_coding | deleterious(0) | benign(0.108) | TCGA-VS-A8Q9-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM241 | SNV | Missense_Mutation | novel | c.730C>A | p.Pro244Thr | p.P244T | Q24JQ0 | protein_coding | tolerated(0.33) | benign(0.083) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM241 | SNV | Missense_Mutation | novel | c.406N>A | p.Ala136Thr | p.A136T | Q24JQ0 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TMEM241 | SNV | Missense_Mutation | rs778244273 | c.824N>T | p.Thr275Met | p.T275M | Q24JQ0 | protein_coding | tolerated(0.11) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TMEM241 | SNV | Missense_Mutation | novel | c.455N>G | p.Phe152Cys | p.F152C | Q24JQ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM241 | SNV | Missense_Mutation | novel | c.95N>G | p.Phe32Cys | p.F32C | Q24JQ0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM241 | SNV | Missense_Mutation | c.287N>A | p.Pro96His | p.P96H | Q24JQ0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM241 | SNV | Missense_Mutation | c.814N>G | p.Ser272Gly | p.S272G | Q24JQ0 | protein_coding | tolerated(0.27) | benign(0.01) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM241 | SNV | Missense_Mutation | c.287N>T | p.Pro96Leu | p.P96L | Q24JQ0 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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