|
Gene: TMEM238 |
Gene summary for TMEM238 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM238 | Gene ID | 388564 |
Gene name | transmembrane protein 238 | |
Gene Alias | TMEM238 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | C9JI98 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388564 | TMEM238 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.85e-09 | 6.36e-01 | -0.2247 |
388564 | TMEM238 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 2.96e-07 | 4.89e-01 | -0.2027 |
388564 | TMEM238 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 1.67e-10 | 3.17e-01 | -0.1433 |
388564 | TMEM238 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 4.70e-38 | 7.71e-01 | -0.1833 |
388564 | TMEM238 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 6.56e-15 | 2.97e-01 | -0.23 |
388564 | TMEM238 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 3.58e-12 | 3.90e-01 | -0.23 |
388564 | TMEM238 | 048752_1579-all-cells | Human | Prostate | BPH | 4.94e-03 | 9.82e-02 | 0.1008 |
388564 | TMEM238 | Dong_P1 | Human | Prostate | Tumor | 5.37e-06 | 6.18e-02 | 0.035 |
388564 | TMEM238 | Dong_P5 | Human | Prostate | Tumor | 4.87e-22 | 1.54e-01 | 0.053 |
388564 | TMEM238 | Dong_P6 | Human | Prostate | Tumor | 5.72e-13 | 6.18e-01 | 0.0371 |
388564 | TMEM238 | male-WTA | Human | Thyroid | PTC | 1.02e-18 | 2.33e-01 | 0.1037 |
388564 | TMEM238 | PTC03 | Human | Thyroid | PTC | 6.13e-09 | 7.25e-01 | 0.1784 |
388564 | TMEM238 | PTC04 | Human | Thyroid | PTC | 5.57e-37 | 1.06e+00 | 0.1927 |
388564 | TMEM238 | PTC05 | Human | Thyroid | PTC | 2.11e-53 | 1.61e+00 | 0.2065 |
388564 | TMEM238 | PTC06 | Human | Thyroid | PTC | 3.77e-71 | 1.60e+00 | 0.2057 |
388564 | TMEM238 | PTC07 | Human | Thyroid | PTC | 4.41e-107 | 1.74e+00 | 0.2044 |
388564 | TMEM238 | ATC08 | Human | Thyroid | ATC | 6.05e-18 | 5.90e-01 | 0.0541 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |