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Gene: TMEM206 |
Gene summary for TMEM206 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM206 | Gene ID | 55248 |
Gene name | proton activated chloride channel 1 | |
Gene Alias | ASOR | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H813 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55248 | TMEM206 | SYSMH1 | Human | Oral cavity | OSCC | 5.23e-09 | 2.63e-01 | 0.1127 |
55248 | TMEM206 | SYSMH3 | Human | Oral cavity | OSCC | 4.77e-07 | 1.86e-01 | 0.2442 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM206 | SNV | Missense_Mutation | novel | c.650A>C | p.Tyr217Ser | p.Y217S | Q9H813 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM206 | SNV | Missense_Mutation | c.835N>T | p.Gly279Cys | p.G279C | Q9H813 | protein_coding | deleterious(0.02) | possibly_damaging(0.794) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TMEM206 | SNV | Missense_Mutation | rs754623496 | c.460C>T | p.Arg154Cys | p.R154C | Q9H813 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM206 | SNV | Missense_Mutation | rs150060518 | c.893N>A | p.Arg298His | p.R298H | Q9H813 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM206 | SNV | Missense_Mutation | novel | c.602N>A | p.Ser201Asn | p.S201N | Q9H813 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM206 | SNV | Missense_Mutation | novel | c.249N>T | p.Glu83Asp | p.E83D | Q9H813 | protein_coding | tolerated_low_confidence(0.08) | probably_damaging(0.98) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM206 | SNV | Missense_Mutation | novel | c.997C>A | p.Pro333Thr | p.P333T | Q9H813 | protein_coding | tolerated(0.07) | benign(0.187) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM206 | SNV | Missense_Mutation | rs747223607 | c.958C>T | p.Arg320Trp | p.R320W | Q9H813 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM206 | SNV | Missense_Mutation | rs373475631 | c.940N>T | p.Arg314Trp | p.R314W | Q9H813 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM206 | SNV | Missense_Mutation | novel | c.1219N>G | p.Thr407Ala | p.T407A | Q9H813 | protein_coding | tolerated_low_confidence(0.38) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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