Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TMEM106C

Gene summary for TMEM106C

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TMEM106C

Gene ID

79022

Gene nametransmembrane protein 106C
Gene AliasTMEM106C
Cytomap12q13.11
Gene Typeprotein-coding
GO ID

GO:0008150

UniProtAcc

Q9BVX2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
79022TMEM106CP65T-EHumanEsophagusESCC3.03e-247.63e-010.0978
79022TMEM106CP74T-EHumanEsophagusESCC2.61e-491.57e+000.1479
79022TMEM106CP75T-EHumanEsophagusESCC6.18e-501.26e+000.1125
79022TMEM106CP76T-EHumanEsophagusESCC3.47e-511.39e+000.1207
79022TMEM106CP79T-EHumanEsophagusESCC3.14e-481.15e+000.1154
79022TMEM106CP80T-EHumanEsophagusESCC2.70e-279.04e-010.155
79022TMEM106CP82T-EHumanEsophagusESCC1.11e-211.37e+000.1072
79022TMEM106CP83T-EHumanEsophagusESCC5.67e-481.60e+000.1738
79022TMEM106CP84T-EHumanEsophagusESCC9.14e-055.29e-010.0933
79022TMEM106CP89T-EHumanEsophagusESCC9.98e-171.64e+000.1752
79022TMEM106CP91T-EHumanEsophagusESCC9.42e-183.09e+000.1828
79022TMEM106CP94T-EHumanEsophagusESCC6.85e-041.08e+000.0879
79022TMEM106CP107T-EHumanEsophagusESCC9.40e-461.24e+000.171
79022TMEM106CP126T-EHumanEsophagusESCC5.43e-055.74e-010.1125
79022TMEM106CP127T-EHumanEsophagusESCC5.95e-142.83e-010.0826
79022TMEM106CP128T-EHumanEsophagusESCC2.10e-591.98e+000.1241
79022TMEM106CP130T-EHumanEsophagusESCC6.90e-1052.45e+000.1676
79022TMEM106CHCC1_MengHumanLiverHCC1.81e-984.07e-010.0246
79022TMEM106CHCC2_MengHumanLiverHCC1.01e-367.12e-020.0107
79022TMEM106Ccirrhotic1HumanLiverCirrhotic7.86e-161.09e-010.0202
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TMEM106CinsertionNonsense_Mutationnovelc.409_410insCAGGCTAAGCTCAACCTGGCAGTATGAACAAAGAAACCCACCCATp.Met137delinsThrGlyTerAlaGlnProGlySerMetAsnLysGluThrHisProLeup.M137delinsTG*AQPGSMNKETHPLQ9BVX2protein_codingTCGA-A8-A08S-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
TMEM106CinsertionNonsense_Mutationnovelc.335_336insAGAAAACTGATACCAGAAGTGGGGCATTGCTATAAAGATACCp.Leu112_Val113insGluAsnTerTyrGlnLysTrpGlyIleAlaIleLysIleProp.L112_V113insEN*YQKWGIAIKIPQ9BVX2protein_codingTCGA-A8-A09C-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TMEM106CinsertionNonsense_Mutationnovelc.351_352insTGAGAGp.Gly117_Ile118insTerp.G117_I118ins*Q9BVX2protein_codingTCGA-A8-A0A6-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyepirubicinCR
TMEM106CinsertionFrame_Shift_Insnovelc.353_354insTCGACGACTCTGCCAAGCCCATGCAGTAAAGCCAGAAp.Lys119ArgfsTer20p.K119Rfs*20Q9BVX2protein_codingTCGA-A8-A0A6-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyepirubicinCR
TMEM106CinsertionNonsense_Mutationnovelc.380_381insTAGAAACAAGCGATTTCTGTCGTGATTCACTGGGGCCp.Lys127AsnfsTer9p.K127Nfs*9Q9BVX2protein_codingTCGA-AO-A0JF-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinSD
TMEM106CSNVMissense_Mutationc.127N>Cp.Phe43Leup.F43LQ9BVX2protein_codingtolerated(0.07)probably_damaging(0.992)TCGA-AA-3715-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
TMEM106CSNVMissense_Mutationnovelc.415A>Cp.Thr139Prop.T139PQ9BVX2protein_codingdeleterious(0)probably_damaging(0.99)TCGA-AA-A01D-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapycapecitabinePD
TMEM106CSNVMissense_Mutationc.617T>Cp.Val206Alap.V206AQ9BVX2protein_codingdeleterious(0.01)benign(0.089)TCGA-CM-5348-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
TMEM106CSNVMissense_Mutationnovelc.350G>Ap.Gly117Aspp.G117DQ9BVX2protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
TMEM106CSNVMissense_Mutationnovelc.242C>Ap.Pro81Hisp.P81HQ9BVX2protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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