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Gene: TMC6 |
Gene summary for TMC6 |
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Gene information | Species | Human | Gene symbol | TMC6 | Gene ID | 11322 |
Gene name | transmembrane channel like 6 | |
Gene Alias | EV1 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R8V2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11322 | TMC6 | P104T-E | Human | Esophagus | ESCC | 6.23e-08 | 3.27e-01 | 0.0931 |
11322 | TMC6 | P107T-E | Human | Esophagus | ESCC | 4.78e-24 | 4.36e-01 | 0.171 |
11322 | TMC6 | P126T-E | Human | Esophagus | ESCC | 2.72e-11 | 8.59e-01 | 0.1125 |
11322 | TMC6 | P127T-E | Human | Esophagus | ESCC | 6.96e-19 | 2.85e-01 | 0.0826 |
11322 | TMC6 | P128T-E | Human | Esophagus | ESCC | 8.12e-32 | 9.51e-01 | 0.1241 |
11322 | TMC6 | P130T-E | Human | Esophagus | ESCC | 5.57e-40 | 6.21e-01 | 0.1676 |
11322 | TMC6 | HCC1_Meng | Human | Liver | HCC | 1.01e-79 | 2.34e-01 | 0.0246 |
11322 | TMC6 | HCC2_Meng | Human | Liver | HCC | 6.22e-17 | 1.29e-01 | 0.0107 |
11322 | TMC6 | cirrhotic2 | Human | Liver | Cirrhotic | 7.94e-06 | 1.16e-01 | 0.0201 |
11322 | TMC6 | S014 | Human | Liver | HCC | 4.50e-02 | 2.59e-01 | 0.2254 |
11322 | TMC6 | S015 | Human | Liver | HCC | 5.01e-09 | 6.56e-01 | 0.2375 |
11322 | TMC6 | S027 | Human | Liver | HCC | 6.49e-18 | 1.21e+00 | 0.2446 |
11322 | TMC6 | S028 | Human | Liver | HCC | 4.94e-31 | 1.19e+00 | 0.2503 |
11322 | TMC6 | S029 | Human | Liver | HCC | 7.51e-34 | 1.29e+00 | 0.2581 |
11322 | TMC6 | C04 | Human | Oral cavity | OSCC | 7.98e-14 | 4.65e-01 | 0.2633 |
11322 | TMC6 | C21 | Human | Oral cavity | OSCC | 7.67e-33 | 9.91e-01 | 0.2678 |
11322 | TMC6 | C30 | Human | Oral cavity | OSCC | 2.18e-37 | 1.46e+00 | 0.3055 |
11322 | TMC6 | C38 | Human | Oral cavity | OSCC | 3.19e-17 | 1.88e+00 | 0.172 |
11322 | TMC6 | C43 | Human | Oral cavity | OSCC | 1.90e-28 | 6.05e-01 | 0.1704 |
11322 | TMC6 | C46 | Human | Oral cavity | OSCC | 2.00e-10 | 3.02e-01 | 0.1673 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC6 | SNV | Missense_Mutation | rs185225783 | c.712N>A | p.Gly238Arg | p.G238R | Q7Z403 | protein_coding | deleterious(0) | possibly_damaging(0.552) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMC6 | deletion | In_Frame_Del | c.384_398delNNNNNNNNNNNNNNN | p.Arg129_Leu133del | p.R129_L133del | Q7Z403 | protein_coding | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |||
TMC6 | SNV | Missense_Mutation | rs750556964 | c.1333N>A | p.Ala445Thr | p.A445T | Q7Z403 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMC6 | SNV | Missense_Mutation | novel | c.272G>T | p.Gly91Val | p.G91V | Q7Z403 | protein_coding | deleterious(0) | possibly_damaging(0.826) | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | c.1380N>G | p.Ile460Met | p.I460M | Q7Z403 | protein_coding | tolerated(0.23) | benign(0.396) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMC6 | SNV | Missense_Mutation | novel | c.2149T>C | p.Tyr717His | p.Y717H | Q7Z403 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs746180217 | c.1951G>A | p.Val651Ile | p.V651I | Q7Z403 | protein_coding | tolerated(0.43) | benign(0.009) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs774998109 | c.2108N>T | p.Ala703Val | p.A703V | Q7Z403 | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs148239603 | c.1916N>T | p.Pro639Leu | p.P639L | Q7Z403 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs551782028 | c.1192C>T | p.Arg398Cys | p.R398C | Q7Z403 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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