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Gene: TMA7 |
Gene summary for TMA7 |
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Gene information | Species | Human | Gene symbol | TMA7 | Gene ID | 51372 |
Gene name | translation machinery associated 7 homolog | |
Gene Alias | CCDC72 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | A0A024R306 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51372 | TMA7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.27e-22 | 1.39e+00 | -0.1706 |
51372 | TMA7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.75e-23 | 1.26e+00 | -0.2061 |
51372 | TMA7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.70e-22 | 1.46e+00 | -0.1462 |
51372 | TMA7 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.35e-18 | 1.05e+00 | -0.0842 |
51372 | TMA7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 7.42e-05 | 6.80e-01 | -0.00410000000000005 |
51372 | TMA7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.37e-20 | 1.14e+00 | -0.0179 |
51372 | TMA7 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.47e-39 | 1.08e+00 | 0.096 |
51372 | TMA7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.57e-13 | 1.10e+00 | 0.0446 |
51372 | TMA7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.15e-21 | 1.08e+00 | 0.0528 |
51372 | TMA7 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.39e-14 | 1.06e+00 | 0.0131 |
51372 | TMA7 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.10e-09 | 7.64e-01 | -0.0177 |
51372 | TMA7 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.05e-16 | 1.32e+00 | 0.0171 |
51372 | TMA7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.91e-18 | 6.25e-01 | 0.0338 |
51372 | TMA7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.35e-31 | 8.06e-01 | 0.0674 |
51372 | TMA7 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.31e-10 | 8.58e-01 | 0.0112 |
51372 | TMA7 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.46e-08 | 1.10e+00 | -0.0124 |
51372 | TMA7 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.17e-27 | 1.22e+00 | 0.0588 |
51372 | TMA7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.78e-28 | 8.18e-01 | 0.294 |
51372 | TMA7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.26e-10 | 1.56e+00 | 0.3487 |
51372 | TMA7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.70e-04 | 3.72e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00021819 | Breast | Precancer | cytoplasmic translation | 80/1080 | 148/18723 | 1.59e-59 | 8.54e-56 | 80 |
GO:000218114 | Breast | IDC | cytoplasmic translation | 82/1434 | 148/18723 | 2.60e-52 | 1.48e-48 | 82 |
GO:000218124 | Breast | DCIS | cytoplasmic translation | 82/1390 | 148/18723 | 2.21e-53 | 1.25e-49 | 82 |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:000218120 | Oral cavity | OSCC | cytoplasmic translation | 133/7305 | 148/18723 | 1.94e-38 | 2.46e-35 | 133 |
GO:0002181110 | Oral cavity | LP | cytoplasmic translation | 124/4623 | 148/18723 | 5.09e-52 | 3.19e-48 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMA7 | SNV | Missense_Mutation | novel | c.83C>A | p.Ala28Asp | p.A28D | Q9Y2S6 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TMA7 | SNV | Missense_Mutation | novel | c.89A>C | p.Lys30Thr | p.K30T | Q9Y2S6 | protein_coding | deleterious(0.03) | probably_damaging(0.913) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMA7 | SNV | Missense_Mutation | novel | c.88N>G | p.Lys30Glu | p.K30E | Q9Y2S6 | protein_coding | tolerated(0.12) | possibly_damaging(0.874) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMA7 | deletion | Frame_Shift_Del | novel | c.187delN | p.Lys64SerfsTer19 | p.K64Sfs*19 | Q9Y2S6 | protein_coding | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMA7 | SNV | Missense_Mutation | novel | c.137A>C | p.Lys46Thr | p.K46T | Q9Y2S6 | protein_coding | deleterious(0.04) | benign(0.115) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
TMA7 | insertion | Frame_Shift_Ins | novel | c.68_69insGCGT | p.Asp23GlufsTer6 | p.D23Efs*6 | Q9Y2S6 | protein_coding | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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